Conserved Protein Domain Family
Mlf1IP

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pfam10248: Mlf1IP 
Myelodysplasia-myeloid leukemia factor 1-interacting protein
This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localization of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.
Statistics
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PSSM-Id: 402039
View PSSM: pfam10248
Aligned: 32 rows
Threshold Bit Score: 118.978
Threshold Setting Gi: 944084623
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKC37456      23 MRNMD-RLFQ-DPFg---------------------MFGGHPMLQgPGRSDpQRGTRAVAQ-WNPAEMSPFG-----FGN 73  Pacific oyster
3_pfamImport   1 MDQMM-NQMM-DPFgvfgm-------------aprhPFMASNALE-DGMQR-SRGSAVAFPrQEMMMRDPFGfggfgAFG 63 
CTP80823      30 MERMT-HGML-NPFgsifnmhspfdsimgepsgtrpSRD-------------------------LALMDPFGfnf----- 77  Brugia malayi
Q566M7        28 MRHMFsGDYGvSPF---------------------------LSLT-DGSVRgLPRPAPSRT-IQQGAVTPYG------MM 72  tropical clawed...
CAF90637      25 MRAMF-GPFGmDPF------------------------AVTPHMQ-PHRA---PRRQ-------AGPLAPFG------MM 62  spotted green p...
Q4V8X5        25 MRSMF-GSFGmDPF------------------------ALTPQIQ-HPRTRiQPQ---------AGALTPFG------MM 63  zebrafish
EFX89103      24 MDSMM-NSMM-DPFas------------------------mMSMHhQMMGIqPPPQQHHP----AGAMVPFGgm-pgFPM 72  common water flea
6_pfamImport   1 MNNLM-SSFFrDPFsdmmfggn------ggrsggmlGIGGPL----------------------GGDLLPFT-------- 43 
NP_001246355  36 MNRLM-NSFMpDPF---------------------------------------------------MQVSPFDq---gFQQ 60  fruit fly
XP_008205210  27 MNSMM-NSMFaDPFgl------------------mgQMQQMQAPAiMDGHNpHNRMVQMP----GMQMMPFG-------- 75  jewel wasp
EKC37456      74 MFgsmFMNMNGM-MSN-----MERSFETA-R----NDPN-AQM--FSQ----SSVYSYTNTgGeGSrPRVYQATSSVrqg 135 Pacific oyster
3_pfamImport  64 GMpdiFAQRRPRrVFGip--rIFREMNGM-AqaamNDPN-GTV--YSS----STMISMDGS-G-RA-PRIVETSTRR--- 127
CTP80823      78 ------------------cdgLMRQMENV-QtqamNDPN-AHV--FSH----STMISFDGRnGgQ--PRVVEKTIRK--- 126 Brugia malayi
Q566M7        73 GMgggFMDMFGM-MND-----LVGNMEQM-T----SGSN-CQT--FSS----STVISYSNMpGgNT-PKVYQETTQTrma 133 tropical clawed...
CAF90637      63 GMgggFMDMFGM-MEE-----MMGNVERM-S----GAPN-CQT--FSS----STVISYSSS-GaGA-PKVYQQTSQTttg 122 spotted green p...
Q4V8X5        64 GMgggFMDMFSM-MSG-----MMENMERM-S----GSPN-CQT--FSS----STVISYSST-DpGT-PKVYQQTSEYrta 123 zebrafish
EFX89103      73 GMgmsPFGMPS--VGQ-----MFQSF---------GQPGfGASpmYSS----SSVMTMTTG-PdGQ-PQVYQASTTTrta 130 common water flea
6_pfamImport  44 ---------GGRhLQSpvammLSGGFPSI------LDPM-GSTgtGSHvsamSTVMTMTQG-PdGR-PQVYQASQSVrqg 105
NP_001246355  61 NAlmeRPQMPAMpAMGlfgmpMMPNFNRLlNa--dIGGNsGAS--FCQ----STVMTMSSG-PdGR-PQIYQASTSTktg 130 fruit fly
XP_008205210  76 -----FPPMPSLnIGR-----MFSNLNGM-S----NDPN-CHS--FTS----SSIMTMTSG-PdGR-PQVYQESMSSrta 131 jewel wasp
EKC37456     136 PGG-VKETRKSERDSERg-tEKMAIGHHIRDRAHVVERTRr-RGGDIEENQELINLDEGEKESFDREFQEK 203 Pacific oyster
3_pfamImport 128 SGD-VKETRRRVQNGDE---EEMVIGHTIGDREHILEKKRd-KDGNVRNQQRFRNLDQAEAEAFDREFKTR 193
CTP80823     127 -TGdVKETRHAIRTGEDgigDKLTIGHTIGDRTHVIEKKRd-RDGRIRERQSFVNLAQDEAEAFDREFASR 195 Brugia malayi
Q566M7       134 PGG-IRETRRAVRDSNSg-mEQMSIGHHIRDRSHIVQRSHnrRTGDQEERQEFINMDENDAASFDEEWSRQ 202 tropical clawed frog
CAF90637     123 PGG-IRETRQSLRDSESg-lERLAIGHHIGSRAHIVERSQnrRTGDREERQDFINLDESDAAAFDEEWRRG 191 spotted green pufferfish
Q4V8X5       124 PGG-IRETRQTMRDSQSg-lERMSIGHHIGERGHVMERSRnrLTGDREERQDFFNLEESEAAAFDEEWRRE 192 zebrafish
EFX89103     131 PGG-VREVQRSVSDSRSg-vRKMAVGRHLGERGHVVEKEQncYTGDSEEREDFINIEEEEAHQFDEEWRRR 199 common water flea
6_pfamImport 106 PGG-IRETKKTVADSRTg-vKKMSIGRHVYDRGHIIEREQnvYSGEREENEEFINMDEEEADDFNKEWESR 174
NP_001246355 131 PGG-VRETRRTVQDSRTg-vKKMAIGHHIGERAHIIEKEQdmRSGQLEERQEFINLEEGEAEQFDREFTSR 199 fruit fly
XP_008205210 132 PGG-VKETKKTVSDSRTg-tRKMAIGHHIGERAHIIEREQnyQSGDQEERQEFINLEEEEAETFNREWETK 200 jewel wasp
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