6C14


Conserved Protein Domain Family
L_HMGIC_fpl

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pfam10242: L_HMGIC_fpl 
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Lipoma HMGIC fusion partner-like protein
This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.
Statistics
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PSSM-Id: 370913
View PSSM: pfam10242
Aligned: 19 rows
Threshold Bit Score: 178.29
Threshold Setting Gi: 75028782
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6C14_B  32 VGVMWGTLTICFSVLVMALFIQPYWIGD-------SVS------------TPQAGYFGLFSYCV-------GNVlsSELI 85 
Q2M056  25 IGVLWAIFTICYAIIGIVAFVTPEWIGD-------PD-------------NDGAGRLGLWQQCQ---------RdeIFDN 75  Drosophila pseudoobscura
Q9XVU1  19 VGAIWVLCGLCTTVLQTLALIHPTWIG-----------------------SDEGGYFGLYDYCG---------------T 60  Caenorhabditis elegans
Q8BM86   8 TGVIWALLSFLSAATSCVGFFMPYWLWG-------SQ-------------LGKPVSFGTFRRCSypvhdesRQMmvMVEE 67  house mouse
Q80WE5   8 VGTFWAFLSLVTAVASSTSYFLPYWLFG-------SQ-------------LGKPVSFSTFRRCNypv-rgdGHNliMVEE 66  Norway rat
Q4RUW4   9 RSMLWTLLSIIVAFAELITFMSPDWLMG-------FPRsdsna---gedsREYRPSLGLYSRCLr------IGSqgVGVS 72  spotted green pufferfish
Q568B9   9 RSMLWTLMSIVVAFAELVAFMSAEWLVG-------YSEgselnftvtashRSDQRTLGIYNRCL-------KVAqqKVVQ 74  zebrafish
Q4S279   9 RSMLWTLLSIVAAFGELIAFMSTDWLVGyp----rTPDavfgrhgataagEAYRPTLGIYGRCIk------LPHlqRGIL 78  spotted green pufferfish
Q7PMA1  11 RSLLWFLVTLIACMTLFGAIVLPKWLIGpeviqirNEEgn--------ftVLRHPSVGIYNRCK--------RMgrIEYN 74  Anopheles gambiae str...
Q9W0X9   9 ASLVWFLCSLVADMLFAVALVTPRWLVGpa----qGTDst--------asSHHQSSVGIYTRCK--------VMqeGGFQ 68  fruit fly
6C14_B  86 CKGGPLDFSSIPSRA----F-KTAMFFVALAMFL-IiGSIICFSLFFVCN-----TATVYKICAWMQLAAATGLMIGCLV 154
Q2M056  76 CRRRWENVLAVPTFS----F-QLATFFMMGAIGLaL-LTIFFLVCLLFMK-----STRVFHICGWMQIISALCMIVACAA 144 Drosophila pseudoobscura
Q9XVU1  61 SECPWSPFRVRPLSM----WfEISAFLVLAATVLsF-LAIFSILLLVLLR-----DRHAFILCSWLHFFAFVFMLAGCVL 130 Caenorhabditis elegans
Q8BM86  68 CGRYA-SFQGIPSTE----W-RICTIVTGLGCGL-L-LLVALTALMGCCVse-liSRTVGRVAGGIQFLGGLLIGAGCAL 138 house mouse
Q80WE5  67 CGRYA-SFAAIPSLA----W-QMCTVVTGAGCAL-L-LLVALAAVLGCCMee-liSRMMGRCMGAAQFVGGLLISSGCAL 137 Norway rat
Q4RUW4  73 CGPYAGTFGEVASGF----W-QAAILFLAAGTLL-L-GGVACISIFSLCFqs-ilKKSLFNICGLLQAIAGLLLMVGLML 144 spotted green pufferfish
Q568B9  75 CGPYATDFMEIASGF----W-QATVIFLVIGIFL-L-SVVGILSVFSMCFqs-ilKKSIFNVCGLLQGIAGLFLILGLML 146 zebrafish
Q4S279  79 CGPYAIHFGEIASGF----W-QATSIFLAAGILL-L-CAVAFISVFTMCFqs-imKKSIFNVCGLLQGIAGLFLILGLML 150 spotted green pufferfish
Q7PMA1  75 CGNFDLNGLLTDSTVfpvpW-KFTMTLMCVGTML-L-GLTLVSTLVTCCRlhsvyGFSMHKLLCIFQGVSAMLVLCGYLV 151 Anopheles gambiae str...
Q9W0X9  69 CGRFDLDGLATDSSVypneW-KAAMFFVMLGFSL-L-SVTVILTLITCCRqs-acGKSIHNMTACAQVVAGICMMLGLFL 144 fruit fly
6C14_B 155 YPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAIlsigDALILSFLAFVLGYR 209
Q2M056 145 FPFGWNSDDFRKICGPEANRFELGLCGIRWAYPLAIigcvDGVVLATLAFILATR 199 Drosophila pseudoobscura
Q9XVU1 131 YPYGWENPRVREIC--ESKKYQLGLCQIRWPYLLAMvlvfDQLCLCCLGFALALK 183 Caenorhabditis elegans
Q8BM86 139 YPLGWDSEEVRQTCGYISGQFDLGKCEIGWAYYCTGagaaAAMLLCTWMACFSGK 193 house mouse
Q80WE5 138 YPLGWNSPEVMQTCGNVSNQFQLGTCRLGWAYYCAGggaaAAMLICTWLSCFAGR 192 Norway rat
Q4RUW4 145 YPAGWGSEKVRGYCGPEAAPFRPALCSLGWAFYAAI----GGTLASFLCAVLSAQ 195 spotted green pufferfish
Q568B9 147 YPAGWGSKKVVDYCGPDASAYKVGLCSLGWAFYTAI----GGTVLTFICAMFSAQ 197 zebrafish
Q4S279 151 YPAGWGSEKVQLYCGQDAAPYRTGLCSMGWAFYTAM----GGTVLTFICAVFSAQ 201 spotted green pufferfish
Q7PMA1 152 YPLAWDAPRVRTLCGPDSEPYSPADCTLGVSIYLGAag----vLLTFLSTVLSRK 202 Anopheles gambiae str. PEST
Q9W0X9 145 HPMGWRANRIQRLCGMDAEPFYPADCSIGVSFYCGIig----vLLTFTAAGISLK 195 fruit fly
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