Conserved Protein Domain Family
Cluap1

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pfam10234: Cluap1 
Clusterin-associated protein-1
This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.
Statistics
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PSSM-Id: 402027
View PSSM: pfam10234
Aligned: 41 rows
Threshold Bit Score: 220.909
Threshold Setting Gi: 557733110
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002904769         14 RSLGYPRPISMENFRT-P-----NFELVSDLLYWMVKKYDPSSSIT-EEIDTEDDRVEFLTQVATEVLAKARIRLNPKKL 86  Phytopht...
Q57WZ2               14 RLLGYPNLISMESFRN-P-----NVELVADCLFWLIKRYEPSAEIV-YEIEREADRVFFFKQVCEVALAKGRVKLNIKKL 86  Trypanos...
XP_010699716          2 RLLGYPRLISMESFRE-P-----NVELVADCLHWLIIRYEPSAEVT-FNIEREHNRVTFFKQVCEVTLAKGRIKLNVKKL 74  Leishman...
Q228X0               14 RALGYSRLISMENFRK-P-----NFELVADILYWLATRVDPQADIP-EQIDEERHRVEFIKAIATLFASKIRIKLNTRKL 86  Tetrahym...
EAY18646             14 RILGYPHPVGIDSFDT-P-----NFGLMANLLHWLATLYDPEIVIL-AELSNEHGRVEFVRGIVQQMAIKSGIRLNPRKL 86  Trichomo...
ESS29279             18 gftgsP--LSFGLFSSgP-----RFLSVADVLRWLALQCTGVKELPkRPLENADDRVAFVEQISELLARHASFCLDVETI 90  Toxoplas...
EDW30817             14 KLLGFPRVFPLQSLAN-QhgslaSFHIVSELIQWLAGLMEPGTVLS-GGVETEEQRVLLVRSATEFFVTKSAIRLNPRKL 91  Drosophi...
WGS:AAPP:GF21268-PA  14 KLLGFPRVFPLQALAS-PhgslaSFHIVAELLQWLAGLMEPGASLP-GGVESEEHRVLLVRSATEFFVTKAAIRLNPRKL 91  Drosophi...
ETN60130             14 KLLGYPNHIPLSVLTT-PyggpeSFKAYSDILQWLINRLEPNLVLA-GGTRSEQERVLFVRSATEFLVTKSSIKMNPRRL 91  Anophele...
Q16GM2               14 KILGYPNNIPLSVLNT-PyggpeSFKAYYDVLTWLIGRLEPNLILA-GGIRSEQDRVLFVRSATEFLVTKSSIKVNPRKL 91  yellow f...
XP_002904769         87 YAADGFAVKELIKLARVLYEASRIDlaa-----qqePDDDDDEVSV---------------------------KSMLGSR 134 Phytopht...
Q57WZ2               87 YQSDGNAVQEMLILANVLKKAMNTTg----------LEEIDHATLQ---------------------------QVIAQRN 129 Trypanos...
XP_010699716         75 YQADGHAVQEMLKLANVLKKAMKATd----------AEEPDFTALH---------------------------QMAAQKN 117 Leishman...
Q228X0               87 YQADGHAVQEIIKVATVLYKAYNSSp----------GDEEENA------------------------------GFTLPSK 126 Tetrahym...
EAY18646             87 YASDRFAVRELLKIAVPIYRGISSS-----------------------------------------------------GR 113 Trichomo...
ESS29279             91 YAAEGAAVKELIRLARTLLNAVQSAinrpalpatleKQLQTISTSTavelmpvsrgdcvghsagrpdgaccidQLAMAAK 170 Toxoplas...
EDW30817             92 YAAAAVTASELQKITRLLIAPSQTEae--------rEEEERDQYRSl-------------------------nQVDIGDK 138 Drosophi...
WGS:AAPP:GF21268-PA  92 YAAASVTAAELQKITRLLTAPGGQTetd------heDEEQRDQYRSl-------------------------nPVDIGDK 140 Drosophi...
ETN60130             92 YASSMAAAQELLKVTSLLIASPKITr----------HEEESIKSHL---------------------------EIDFSDK 134 Anophele...
Q16GM2               92 YASSAAAAKELLKVTSLLIASPKVTg----------ADEESIKSHV---------------------------EIDLSDK 134 yellow f...
XP_002904769        135 VKDPKAT-----------RQLASDITQSGAKLYDLLDTELD------VRDARQQAIRfldalstnheNSSEQKFLERSIQ 197 Phytopht...
Q57WZ2              130 VQDAKRV-----------QQLCSDLTNDGSSLFFLIEEETG------QRGERQRVLS----------RATEVGEFERRLR 182 Trypanos...
XP_010699716        118 VSDAKAV-----------QQLCSELTTDGSSLFFLVEAELN------SRGDRQRILS----------RATEVGEFERRLR 170 Leishman...
Q228X0              127 LSNIKAH-----------RAIANDITEIAQKLFDSLNKEND------LQQHRDKALQfldnisrnleSNSEQAYIEQCVR 189 Tetrahym...
EAY18646            114 LADTKTTsfpknqntqkiSQLSATVPRHSVELYDQLDKEVQ------IRETRTKILS----------TVPSLDEVEKSVL 177 Trichomo...
ESS29279            171 LQQLNLS-----------RSAASQLVDTAASLLQAFERHSRpervilRRRVRDFLLRlglh--ldsgADQELEHIQLQLA 237 Toxoplas...
EDW30817            139 MEELRRA-----------RELSSDLTQRGAALYDLLSKELQ------HKESRQTQAQ----------RPMELLSVERTLK 191 Drosophi...
WGS:AAPP:GF21268-PA 141 MEDLRKA-----------RELATDLTQRGATLYDLLSKELL------NKEARTAQAQ----------RPLELLSVERTLK 193 Drosophi...
ETN60130            135 MNDLKMV-----------RGLSSELTNKGAVLYDLLKKELV------NREIRNAQST----------RPIELATAEKVIK 187 Anophele...
Q16GM2              135 MDDLKKV-----------RGLSSELTNRGAALYDLLKKELV------NRETRMVQST----------RPLELATVEKVIK 187 yellow f...
XP_002904769        198 DILVNlqENVELTERQVVELDAEEKALAAKIKKAQTDLERSEKRLKSLQHVRPAFMDEYEKLEKELERQYAIYCERFRNL 277 Phytopht...
Q57WZ2              183 EVLKDvtTQVEQLQASIANLSADETTLEQKIESKKTQLERTQKRLKSLNAVRPAFMEEYEKHEGDMHSQFVIYLEQYRNL 262 Trypanos...
XP_010699716        171 ELLTNvaQEVDQYQQSIVNLSADETNLEQKIENKKAHLERAQKQYKSAMATNPAFLKEYENHEKKLQAQFVNYLEQYRNL 250 Leishman...
Q228X0              190 EIIKQqdQGIIDMQNYVSNLEKEQKNIEDKTKKLTIELQKQQTLLYNLKVMKPAYMEEYIRLEYELEKLYQIYIEKFRNL 269 Tetrahym...
EAY18646            178 ESVDGaaARLEQLTKELDRLNSDEDALNTKIKQRKHEYERQSKRLMSVQTIRPAYMEEYEMLEQELGELFKTYFQHYRNV 257 Trichomo...
ESS29279            238 EQLRRakADLLDTQHACLDLENELT----------QDSDRAQKRLQSLQNLKPAFLEDHKKLMAELQETYDMYVACVRNE 307 Toxoplas...
EDW30817            192 NATQAsqLKLQSSRAQLEAARVELNALNSKLQRKRAELERTKQRLEALQKIRPAHMAEFEECEKELQMLFQRYFLRLHVR 271 Drosophi...
WGS:AAPP:GF21268-PA 194 NAIQSnqLRLQSSKAQLEATRVELNALGSKLQRRKAELERTRQRLEALHRIRPAHMAEFEDCEKELQQLFQRYFLRLHVR 273 Drosophi...
ETN60130            188 GAISTvqSKLSGSTTALESLRNENTNLESKMRRKASELERSRQRLQALQKVRPAYLEEFEKLEQELKGLYEQYIVRIKCV 267 Anophele...
Q16GM2              188 SAITSldSKLVASKASLESLKAENGNLTAKIQRKSSELERSKQRLQALQKVRPAYLEEFEKLELELKNLYEQYIIRIRCV 267 yellow f...
XP_002904769        278 DYLQRELDLHN-SREMK 293 Phytophthora infestans T30-4
Q57WZ2              263 EYLEHELAKFN-AAEDA 278 Trypanosoma brucei
XP_010699716        251 EFLEHQIAKYN-AKEDV 266 Leishmania panamensis
Q228X0              270 DYLENELDQYN-LIEKK 285 Tetrahymena thermophila SB210
EAY18646            258 DYFEKEISKQAeKVKKN 274 Trichomonas vaginalis G3
ESS29279            308 RFLEMEAEKRQaKArag 324 Toxoplasma gondii VEG
EDW30817            272 DALRSQLEART-KRTTP 287 Drosophila persimilis
WGS:AAPP:GF21268-PA 274 DALRFQLESRT-KRATP 289 Drosophila ananassae
ETN60130            268 DTLRAQIISKN-RTPTP 283 Anopheles darlingi
Q16GM2              268 DALKSQLISKN-RTPTP 283 yellow fever mosquito
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