Conserved Protein Domain Family
Adaptin_binding

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pfam10199: Adaptin_binding 
Alpha and gamma adaptin binding protein p34
p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.
Statistics
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PSSM-Id: 370877
View PSSM: pfam10199
Aligned: 29 rows
Threshold Bit Score: 41.6999
Threshold Setting Gi: 121972201
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS69940     277 DKDGIERIREALMNHMWNG-LIRKDQTAslsnrnasletgpalfassdahpsfsdsavgrfkgdeedtdpaeaiqdsaes 355 Ustilago maydis...
Q0UDD8       171 EKVGVHRVRESLEACEWES-AEGIDFGAdedgeegfg------------------------------------------- 206 Parastagonospor...
EDN03445     313 EFQGMARVKEVLQTNEWAS-IRQGDLSTdflldsded------------------------------------------- 348 Histoplasma cap...
XP_001402030 286 ELQGMRRIKEVLETHDWAA-TEDAETGLlhdgvdddlerellg------------------------------------- 327 Aspergillus nig...
Q5BBS4       297 ELQGMRRIKEVLETHEWAG-DEEGEVDTslpdddddlerellg------------------------------------- 338 Aspergillus nid...
Q0D030       250 EYQGMRRVREVLETHQWAAaESDAKSDdgdadelerellg---------------------------------------- 289 Aspergillus ter...
XP_001271901 281 EYQGMRRIKEILETHDWSAaAEDADGEEsgmldeddleaell-------------------------------------- 322 Aspergillus cla...
A0C1I4       172 ETLGFPRIIEIMECNTWTY-MRPKSQE----------------------------------------------------- 197 Paramecium tetr...
O13827       150 EKVGLDRVREILDCCEWNL------------------------------------------------------------- 168 Schizosaccharom...
Q6FWX8       184 ECKGMARLKEIIDTHPWTD-CKV--------------------------------------------------------- 205 [Candida] glabr...
KIS69940     356 alepsslrhhlatigdsfsdntgfpmldsnahadasdldeqlaklflsandgaraadlAQLEAFLESQDPSWPASTPPPK 435 Ustilago maydis...
Q0UDD8       207 --------------------------------------------------gfaaeeaeMNMELFDMKGALHGFDDEEAGE 236 Parastagonospor...
EDN03445     349 -------------------------------------------------fgfdneaseLEREMLGLKLAIEKGADE---- 375 Histoplasma cap...
XP_001402030 328 --------------------------------------------lddadngfdlevdeLQREMVGLRMAIERG------- 356 Aspergillus nig...
Q5BBS4       339 -------------------------------------------ldkeatsgfkdevdeLQREMVGLRFAIGR-------- 367 Aspergillus nid...
Q0D030       290 ---------------------------------------------lddeagfdwevgeLEREMVGLRFAMERGEEFE--- 321 Aspergillus ter...
XP_001271901 323 --------------------------------------------glnaengfnlevneLEREMLGLRMAIERG------- 351 Aspergillus cla...
A0C1I4       198 ----------------------------------------------------------KKENTGKTKVSEKQTQGLDQLE 219 Paramecium tetr...
O13827       169 ----------------------------------------------------------SQVDKSFSEEKDDAGDFYLPER 190 Schizosaccharom...
Q6FWX8       206 ----------------------------------------------------------VLKNKESTSDKVNKP------- 220 [Candida] glabr...
KIS69940     436 saadpESadarfdddfddflpfqsalsdatqstsqnasadvddlptmddisqmqnhlfggLAAARIEanppgaatrsnst 515 Ustilago maydis...
Q0UDD8       237 psaeaE--------------------------------------------------------AKEVE------------- 247 Parastagonospor...
EDN03445     376 -----TGagepdl------------------------------------------kshdeEDELHVE------------- 395 Histoplasma cap...
XP_001402030 357 -----GGdgfdd--------------------------------------------ddegDEELRVD------------- 374 Aspergillus nig...
Q5BBS4       368 -----CGdgnvd--------------------------------------------edegDEELRVD------------- 385 Aspergillus nid...
Q0D030       322 -----GDdqgeg--------------------------------------------dgdgDDERRVE------------- 339 Aspergillus ter...
XP_001271901 352 -----GDgiged--------------------------------------------eddnDDGLQVD------------- 369 Aspergillus cla...
A0C1I4       220 ---------------------------------------------------------------FEDD------------- 223 Paramecium tetr...
O13827       191 fkgspDM-----------------------------------------------------QST----------------- 200 Schizosaccharom...
Q6FWX8           --------------------------------------------------------------------------------     [Candida] glabr...
KIS69940     516 ygDLASQLQQLQMHAQRVRNITDa-----DQRRKEAALVALA 552 Ustilago maydis 521
Q0UDD8       248 --ELEVMMRKMIAVKEMGEGMEE------AERKRFAAKAVND 281 Parastagonospora nodorum SN15
EDN03445     396 --KIDGLMLRMKAIKDMAAELPE------AERRAFAVKAIND 429 Histoplasma capsulatum NAm1
XP_001402030 375 --AVEALLLRMRAIKDISDELPE------AERKRFAAKAVRD 408 Aspergillus niger CBS 513.88
Q5BBS4       386 --AVEALLARMRAIKDMSAELPE------KERKRFAAKAVAD 419 Aspergillus nidulans
Q0D030       340 --SVEGLLLRMQAIRDMSDELPE------QERKRFAARAVRD 373 Aspergillus terreus NIH2624
XP_001271901 370 --SLEALMMRMQAIRDMSAELPE------GERKKFAAKAVRD 403 Aspergillus clavatus NRRL 1
A0C1I4       224 --QFAQLMHDMTKIRTSK--MTD------EERREKAANLMNQ 255 Paramecium tetraurelia
O13827       201 --DLDNLMKEMNQIRDAD--LEK------NEKKAKALNLLEK 232 Schizosaccharomyces pombe 972h-
Q6FWX8       221 --DLEYLIDTLKKAKIHYQKLSNgsdgfsEEAEQFALQMATD 260 [Candida] glabrata CBS 138
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