Conserved Protein Domain Family
Ada3

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pfam10198: Ada3 
Histone acetyltransferases subunit 3
Ada3 is a family of proteins conserved from yeasts to humans. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumor suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage.
Statistics
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PSSM-Id: 402001
View PSSM: pfam10198
Aligned: 83 rows
Threshold Bit Score: 77.2278
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014174786 445 LDYTQVDERIKQELRHIGFLpfpdsahgssvvnstgngmgginnssgggnsngnggnsngngngsgngnsngsnganghg 524 Grosmannia clav...
EFN68943     320 qNSMNLELRMHKELVEQGIL------------------------------------------------------------ 339 Florida carpent...
XP_001605876 323 qNSMNLEMRMHKELVEQGIL------------------------------------------------------------ 342 jewel wasp
Q1HQA8       326 KNSLTLEKCLRKELVEQGIL------------------------------------------------------------ 345 domestic silkworm
2_pfamImport   1 ---ILMEKRVKKELIEQGIL------------------------------------------------------------ 17 
Q17C72       363 kNGISIERRLRKELIEQGIL------------------------------------------------------------ 382 yellow fever mo...
XP_001991023 472 KHGVGIEQRLRKELIESGLI------------------------------------------------------------ 491 Drosophila grim...
XP_002071550 414 KHGLGIEQRLKKELINTGLIe----------------------------------------------------------- 434 Drosophila will...
EDW29671     420 KHGVGIEQRLKKELLENGLM------------------------------------------------------------ 439 Drosophila pers...
XP_002115483 321 sqWKTLDKRIREELITLNIIsrsd-------------------------------------------------------- 344 Trichoplax adha...
XP_014174786 525 sgggngngsanggggnaaIdPSLTADydGHYDDEVAARLRLLQSKLREQMLMNGARKARLAELVKERMAYQEYQTILEDL 604 Grosmannia clav...
EFN68943     340 ------------------E-PDAQKk--NQEDDEILAEIKRCQQELSALSSHNVVQLKRLFNLAQEESKRQALKRKISNA 398 Florida carpent...
XP_001605876 343 ------------------E-PDSQKk--NQDDDEIVAEIKRCQRELTALSSHNEMQLKRLLHLAQEESKRQALKRKIASV 401 jewel wasp
Q1HQA8       346 ------------------D-PEDLPPltNPADDEILAEIKKCQTELTAVRKENCRNLKNLIGLCKQEMIRLNLKKQLDQV 406 domestic silkworm
2_pfamImport  18 ------------------E-DEPI----KHEDDEILSEIKRLTTELNAVAEFNHNELLRLHTSSKAELQRLEIKRKLDIV 74 
Q17C72       383 ------------------D-DDDMPk--SQQDDEILSEINRVRTEIAVIAEYNSNEIRKLQSMAQDEMKRIEVKRKLDRV 441 yellow fever mo...
XP_001991023 492 ------------------E-ANELAk--HEDVDEVLLEIKRVTAEISAVAQFNSDELKRLRSAASDEIKRIELKRKLDTI 550 Drosophila grim...
XP_002071550 435 --------------------SAEPDD-----VDEVLLEIKRVTAEISTISHFNSEELKRLRQAASEEIKRIELKRKLDFV 489 Drosophila will...
EDW29671     440 ------------------D-ASDCAp--PEDTDDVLHEIKRVTAEISTVSTFNSEELKRLRLAASDEIKRIELKRKLDMI 498 Drosophila pers...
XP_002115483 345 ---------------ivaD-SDGRN---NDDEDEVLSELHRRQQELKAVNQENVAFIQQLKEASIRETKRQKLLQSVRVC 405 Trichoplax adha...
XP_014174786 605 DGQVQAAYLK------RTRTMGKSKKGkrpgaggagaggaggaggaaggangagtARPGIGDMTRLLME 667 Grosmannia clavigera kw1407
EFN68943     399 DNEVVEHYKKltkakqNKESLTRKEQE----------------------------------KAWACLRE 433 Florida carpenter ant
XP_001605876 402 DNQVVEHYEKlllakqRKVPLSRKEQE----------------------------------KAWTCLKE 436 jewel wasp
Q1HQA8       407 DLECIDIYKKmvaakqKKRPVTKKEKE----------------------------------DAWKAINE 441 domestic silkworm
2_pfamImport  75 DQEIVESYKKvvaakiKKRPLSIDEQD----------------------------------DINRLIHE 109
Q17C72       442 DQEIIECYKKimaarlKRRPLTKQEKD----------------------------------EAYRLAEE 476 yellow fever mosquito
XP_001991023 551 DQEILECYKRmlqyraKRKGHTAEERQ----------------------------------EIMRLTSE 585 Drosophila grimshawi
XP_002071550 490 DQEILECYKR------MLQYRSKRKGH----------------------------SLEEKQEILRLTNE 524 Drosophila willistoni
EDW29671     499 DTEILECYKRmlqyraKRKGHTVEEKQ----------------------------------EILRLTKE 533 Drosophila persimilis
XP_002115483 406 DNEVIDYYKRfaptksKKKGLTKEETE----------------------------------RAWQLLKS 440 Trichoplax adhaerens
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