Conserved Protein Domain Family
PIG-H

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pfam10181: PIG-H 
GPI-GlcNAc transferase complex, PIG-H component
PIG-H is a family of conserved proteins that complexes with three other proteins to form the GPI-GnT (glycosylphosphatidylinositol anchor biosynthesis transferase) complex. It appears to be a peripheral membrane protein facing the cytoplasm involved in the first step in GPI anchor formation.
Statistics
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PSSM-Id: 401989
View PSSM: pfam10181
Aligned: 97 rows
Threshold Bit Score: 53.9859
Threshold Setting Gi: 410729799
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESW97698           131 SLIIIPNLGVQSESYrvrksgsalvllllsrvlgkselsrhvpaaktLNRQFFPMEDVHDLAIVEGFKNFQVIFYLALMV 210  Ogataea ...
XP_016292525       680 SVSLLPGMGVQLATTrglvlh--------------------ttlferTTTRLILEDRVVDIYVGEGYRFFSVIDYLALAT 739  Kalmanoz...
CBQ71775           684 SVSVLPGLGVQLATTralrvfg-------------------ktvferRSSRLVPEDRVVDVYVGEAYRLFSVIDYLALAT 744  Sporisor...
WGS:AEVR:RTG_00768  71 mleVFPSLGLQLASRtvyhlslpft------------ssmpvmfrssRKTHLIPLERIDKVAINEGLQGAGGRHYLAVVK 138  Rhodotor...
XP_002904207        89 SMLVVPALGVKLSKRrrn---------------------------gvVSSKFVYLDQICGVAVNEAITFSNVVYSLVLMI 141  Phytopht...
CBJ31445            66 fLLVVRELGVQVTTKyvd---------------------------grEKTTFLDKAKIKAILINEGITMHRVVFYLAFVV 118  Ectocarp...
EFA80321           109 SLTVIRELGVQLRKKyyf---------------------------igESTRFIEKPKIQSIIINEGISRYRVTFYMAFLV 161  Heterost...
Q86K35              78 SLIVMREIGVQLKRKyfl--------------------------rpsTVVEFIEKSKIEQIVINEGITKHNVIFYMAFIV 131  Dictyost...
XP_004354906       144 SMVIMRELGVQLTRKyyl--------------------------kffNKVEFIDKTKIQSIVINEGISRYSVTFYMAFIV 197  Cavender...
EPB84138            65 SILAIRDVGIQVKTTywg---------------------------gsSVSRFINRNKIDDVIINEGISFWQIKSYMAILV 117  Mucor ci...
ESW97698           211 GDGQqd--dQlqIVVIFP 226  Ogataea parapolymorpha DL-1
XP_016292525       740 RTQT-----GasIERVFP 752  Kalmanozyma brasiliensis GHG001
CBQ71775           745 SSSR-----GahIERVFP 757  Sporisorium reilianum SRZ2
WGS:AEVR:RTG_00768 139 KGSGgaeeeErrVFVVFP 156  Rhodotorula toruloides ATCC 204091
XP_002904207       142 ETQS-----D--MVLPFE 152  Phytophthora infestans T30-4
CBJ31445           119 AG-------RdkMVVAFE 129  Ectocarpus siliculosus
EFA80321           162 EG-------KqkMVLAFD 172  Heterostelium album PN500
Q86K35             132 EG-------KnkMVLAFE 142  Dictyostelium discoideum
XP_004354906       198 EG-------KskMILAFE 208  Cavenderia fasciculata
EPB84138           118 KD-------EdkMVVVFE 128  Mucor circinelloides f. circinelloides 1006PhL
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