6N86


Conserved Protein Domain Family
Ric8

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pfam10165: Ric8 
Guanine nucleotide exchange factor synembryn
Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.
Statistics
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PSSM-Id: 401973
View PSSM: pfam10165
Aligned: 103 rows
Threshold Bit Score: 229.372
Threshold Setting Gi: 403161519
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6N86_B        86 WLQSIRILSRDRSCLD-SFTSRRSLQALac---------------------yaGIsasqgsvp--eplnmdvvLE--SLK 139 cattle
CDS39817      54 AIVCLLILSRDPDYQK-RLSECDMLHLLfr---------------------eaAIlpdspk------ppdeciVG--ALK 103 Echinococcus mu...
XP_018644182  51 CLCCLRILTRDNILRK-ELTSEFFLSQVfk-----------------------yAfeyncnl-----eysktsLE--ALK 99  Schistosoma man...
XP_002121749  71 ALSVLLFLSRDRELVSkCLASADFTKYLlk---------------------hsKLngapiatdtdgdvelnlkIEllACK 129 vase tunicate
EDO46011       1 -LNALRILSRDKNGLG-LLTSEKSSKALtcigptevdtvylrmmnydgcvktsGTi-----------------IE--SLK 59  starlet sea ane...
CDP96267      67 ILRFLRILARDRQNLD-HLLSSSLVQDVln---------------------iaLLaeqsfe------fdweafIQ--AEM 116 Brugia malayi
EFO26882      67 ILRFLRILARDKQNLD-QLLSSGLVQDVlg---------------------vgLLterlfe------fdwesfIQ--AEM 116 eye worm
XP_003091664  66 LLETVRLLSRERDGLE-SLLNNDLCDKIlr---------------------haALkwedgyp-----ksvhalME--AQK 116 Caenorhabditis ...
Q61A92        67 LLETVRLISRERQGLE-SLLNENLCDTIlk---------------------laGItpvvgyp-----rsvhalME--AQK 117 Caenorhabditis ...
EGT48653      66 LLETIRLLSRDRNGLE-GLLNVDLCNKVla---------------------faGLqtgegvp-----knphalME--AQK 116 Caenorhabditis ...
6N86_B       140 CLCNLVLSSPVAQALaaeaglvvrLAERvglc--------------------------------------rqsSFPHDVQ 181 cattle
CDS39817     104 CLSNVIFKNPEVIQDlrlkhcldaLLDRceaq--------------------------------------ikgSPNFQIA 145 Echinococcus mu...
XP_018644182 100 SLSNILFKESCVIEPlktmgliksVMESvdil--------------------------------------ietENNER-L 140 Schistosoma man...
XP_002121749 130 CLCNVLFITNDANDTftdhqflksVTEKive----------------------------------------hqSRPDEHT 169 vase tunicate
EDO46011      60 CLCNIMYHSAPAREHcikfdvtlsLLHRlknw--------------------------------------adkSVPQDVF 101 starlet sea ane...
CDP96267     117 CLINILFNSNLARNEfndi-asnlLLNRirilsetprisfmqrevpvtv---qdvaifteskipefpvknlnnEQIDLVT 192 Brugia malayi
EFO26882     117 CLINILFNSKLARDEfnei-asdlLLSRirllsetsrssskqrnnddiratekdigisakpkifeslveflnnEQIDLVA 195 eye worm
XP_003091664 117 CLVNTMFHSAKMRDRfyldsqnseNILQflsefdesqrke----------------------skiewiremnqVQSSEVW 174 Caenorhabditis ...
Q61A92       118 CLVNTMFHSAKMRERfymnlvngdQIQRflsefedsrren----------------------sniqwiremnpTQAAEVW 175 Caenorhabditis ...
EGT48653     117 CLINTMYHSQRMRDVfyateenseNLLFyllefspqnrkt----------------------sehqwiremheVQAAEVW 174 Caenorhabditis ...
6N86_B       182 FFDLRLLFLLTALrTDVRQQLFQELQGVRlLTRALELTLGMTEG-ERHPELLPPQETERAMEILKVLFNITFDSIKREVD 260 cattle
CDS39817     146 LFDLKVLFLCSALeSASRLEILTSRFESDiFVNLLRWTLASDFS-------VHPQMFDITIETLKLLFNLSYAKKERDYD 218 Echinococcus mu...
XP_018644182 141 LLCLKLLFLVTALdSASRQELIKS-NALQmLMKIVKMKSSKITD------------LNVSAEALKVVYNILYSTRDDVTK 207 Schistosoma man...
XP_002121749 170 VITLRLVFLITALsAKGRNLFIENHNARTvLVQFLEYKINQVNDtDREGKVFTPKQVEVVDEILKVLFHLNVDLRKSSMY 249 vase tunicate
EDO46011     102 YFDLRLMFLLTAFeGAIRKTAFEN-KGLCiLTHALDSQVPGKDD----RDRTHSSNGKDGSEILKVIFNVTMAMPKELTH 176 starlet sea ane...
CDP96267     193 SYDLRIAFVASAQsKDLQLRWLKNGCEV--FLKVLERSLCFPER--LRRDLQWKNFVEHTNWALKVLFNIFCYSWDDSVQ 268 Brugia malayi
EFO26882     196 FYDLRIAFVASAQsKDLQLYWLKDGCEV--FLKILEQSLHFPER--LKQNSRWRSFAEHTNWALKILFNIFCYSRDDSVE 271 eye worm
XP_003091664 175 YFYHRIAFIATAMnRDFQKSWANNPQMIDhLLTAVRCVLGKTSV--------PQIDLLRANEALKSFFNVFCHFHGEVEA 246 Caenorhabditis ...
Q61A92       176 YFYHRIAFIATAMdKGFQRHWADQSTTVSnILCAAEVCLQKASD------DVANLDLLRANEAMKTFFNVFCHFHGDVPG 249 Caenorhabditis ...
EGT48653     175 FFYHRIGFISTAMsRDFQKKWANEPKMIDnLLPAVEYIIEKKDF--------ISQDRERANEALKTFFNIFCHFHGEVQA 246 Caenorhabditis ...
6N86_B       261 eed-aaLYRHLGTLLRHCVM-LAAAGdrte-elhGHAVNLLGN-LPVkcldvlltlephEGSL--Efl------------ 322 cattle
CDS39817     219 qrlyesTYRDLTTVIRELLV-KFVEPrerrmelvSHSVNFLTS-VPSacyvgllfpssnVDDS--Lrsgdf------htd 288 Echinococcus mu...
XP_018644182 208 el--gdDIRNLVVMLRCILQ-DPMLSefnsyalvSQVVNVLNI-IPKhlykhlldgnfnDHAT--Dnlikds---apenk 278 Schistosoma man...
XP_002121749 250 stqevsDLDLTLSLCRTVLL-STCEDekrteslhCHAGNAIYSvPPQqlkmklligeksEQVQ--Eesl---------rk 317 vase tunicate
EDO46011     177 et--qeHYERIALITSTLFT-HVKALpdgaenvhNHAMNAINS-MPKeamhflywgfpkSVGK--Af------------- 237 starlet sea ane...
CDP96267     269 s-----NAKQCMVLCSRIIT-IKNIDpsl----eqsAVDVIAV-LPLsfell--tpklqHIEQ--Kdtni-------ihd 326 Brugia malayi
EFO26882     272 s-----NAKQCMLLCSKIVT-LENIDpsl----eqsAVDVIAV-FPLsfell--tpkiqHTEK--Kdtnv-------ihg 329 eye worm
XP_003091664 247 in--kkKAMEACEVLRDTICsVDIVGddv----iqsAIHALSV-PPLpmilsvicgdptVPLD--Ttssidnqsieeere 317 Caenorhabditis ...
Q61A92       250 ld--ekNTHLACRILRDVIC-SGIPNddv----iqsAIHALSV-PPLpmdlsvllsdpnfpivplpetiseeervhprdy 321 Caenorhabditis ...
EGT48653     247 id--qkHAIKATRILRDIIC-SDRSDdel----imsAVHAVSV-PPLpivlsvwcqdpeKDAK--Ataeddev-vdlfre 315 Caenorhabditis ...
6N86_B       323 gVNMDVIRVLLSFMEKrlh-----------------qtHRL--------KESVAPVLSVLTECARMHRPARKFLKAQVLP 377 cattle
CDS39817     289 pQVTRALSVLVEFLTYqld-----------------qdDKSps----rsGHLLSPILTVMATASKVNRTIRKYLRMRLLP 347 Echinococcus mu...
XP_018644182 279 tNGMSSIETLIDFLHSqlkl---------------dagKESetasdirtDERICPILNCLTRASKSNRQIRKFCRLKVLP 343 Schistosoma man...
XP_002121749 318 tERFAPIKSLLYILEHrvmn-------------------------niitVDVLQPLLALLSQLSRCSADVRKALKAEILP 372 vase tunicate
EDO46011     238 tNNMAAIMSLLKHIESrid-----------------ssN----------ADSLVPEISALCCLAKGDSIIRKYLRLEILP 290 starlet sea ane...
CDP96267     327 gRDMTFADAVLHALERrlea---------------essER---------NELLGTFLTVLIRLSSQVKEARRYLRLLVIP 382 Brugia malayi
EFO26882     330 gRDMTFANAVLHALERrlea---------------ennEK---------NELLGTFLTVLIRLSSQVKEARRYLRLLVIP 385 eye worm
XP_003091664 318 fKNMTMIEALLMALDKqlaravallnstpndqvsqeanTL---------TDLTGPYFQALARLCVESKHVRRYCRIRVLP 388 Caenorhabditis ...
Q61A92       322 yVNMTLTEAILAALDKqlikavdllnsvpfnqvspegnTL---------VDLSGPYFQALARLCVESKYARRYCRIRVLP 392 Caenorhabditis ...
EGT48653     316 yDDMKMTEALLSSLDKqltvavkmlnntphdkvsteanTL---------CDLIGPYFQALARLCVESKHARRYCRIRVIP 386 Caenorhabditis ...
6N86_B       378 PLR--DVRT---RPEVGELLRNKLVRLMTHLDT-D--VKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAggr 449 cattle
CDS39817     348 HLGa-DVKR---LPETGNTLRNRLCSRLTAKANlDdgTVEAVALLIFILCKEKVDRAVKYSGFGNFVGFLSRHGLMApsg 423 Echinococcus mu...
XP_018644182 344 YLGk-DVKR---LPEDGDNIRNYLCKLLTHPVQ-I--VGESAALFIFVLCKENIGRAVKYTGFGNFAGFLARHALLGkps 416 Schistosoma man...
XP_002121749 373 PRK--DFHR---RPEDGDALSNKLVKLCTHANV-E--VKNGIADFLFVLCKENVDRFVKYTGYGNAAGLLAARGLLAggf 444 vase tunicate
EDO46011     291 PLQ----AVshtRPEEGSAIKNKLIKMMTAPGD----IRDMVADFLFILCKENTDRLIKYTGYGNAAGLLARKGLMAggq 362 starlet sea ane...
CDP96267     383 PLHatDVER---RPDDGAELRNRMIRLMMSISN----TQDLAAEFIFILCKKSVNRFVKYCGFGHAAGLLANRGILNaln 455 Brugia malayi
EFO26882     386 PLHatDVER---RPDDGIELRNRMIRLMMSISN----IQDLAAEFIFILCKKSVNRFVKYCGFGHAAGLLANRGILNaln 458 eye worm
XP_003091664 389 PLVadEVKK---RPEEHNSLRGRIVRIMMLPSA----TKDVAAEFLFIICKRSVNRMIKYVGFGHSAGHLANLGLLGqin 461 Caenorhabditis ...
Q61A92       393 PLVadEVKK---RPEEHDSLRGRIVRVMMLPST----TKEVASEFLFIICKRSVSRMIKYVGFGHSAGHLANFGLLGqin 465 Caenorhabditis ...
EGT48653     387 PLVadEVKK---RPEEHDSLRGRIVRIMMLPSA----TKDVAAEFLFIICKRSVNRMIKYFGFGHSAGHLANMGLLGqin 459 Caenorhabditis ...
6N86_B       450 peg-----------qysedeDTDTDEYKEAKASINPVTGRVEEKPP-NPMEGMTEEQKEHEAMKLVNMFDKLSRH 512 cattle
CDS39817     424 grggd-------dayssassDSETEDYRELKDQINPVTGRVEPPRC-NPMEGLSDEQKEFEAMQLVNKIDQLQRS 490 Echinococcus multilo...
XP_018644182 417 kvnresncnvesdeysatstESETEEYKRLKEDVNPVTGRWEIPQP-NPMENMSEEQKEYLAMDLVQKIDKLERS 490 Schistosoma mansoni
XP_002121749 445 gete----------ysdcdsDSDTEEYKIASHQINPVTGHVQPPQN-NPMEGMSDEQKEYLAVKLAQEISQLSRL 508 vase tunicate
EDO46011     363 gngg---------eyssdeeNSDTDEYVQVKNQIDPIIGAIPPDRP-NPLDGMTDEEKEEEAMKLGEMIEHLNKM 427 starlet sea anemone
CDP96267     456 tsk-----------hqsdseASETEDYKAVETQVNPVTGCIEPAGE-NPFTGMTEEQKEYEVHRLMNDINKLMNQ 518 Brugia malayi
EFO26882     459 tpk-----------hhsdseASETEDYKAVETQVNPVTGCIDPAVE-NPFTGMTEEQKEYEVHRLMNDINKLMNQ 521 eye worm
XP_003091664 462 qpk-----------hasdseDSETEDYNKVKDCVNPVTGAMYPPDHgSALAGMSDEQKEYEAMKLVDAMNKMMET 525 Caenorhabditis remanei
Q61A92       466 qpk-----------hasdseDSETEDYNAVKDNVNPVTGAMYPPDHgSAMDGMSDAQKEFEAMKLVDAMNKLMDQ 529 Caenorhabditis briggsae
EGT48653     460 qqk-----------hasdseDSETEEYNQVRDNVNPVTGAIYPEDHgSALAGMSDEQKEYEAMKLVDAMNKMMDA 523 Caenorhabditis brenneri
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