5SVA


Conserved Protein Domain Family
Med17

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pfam10156: Med17 
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Subunit 17 of Mediator complex
This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.
Statistics
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PSSM-Id: 401965
View PSSM: pfam10156
Aligned: 26 rows
Threshold Bit Score: 294.211
Threshold Setting Gi: 74683266
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5SVA_P        11 LSSETGIKLALDPNLITLALssnpnsslhsptsdepvpesagkadtsirlegdelenktkkdndknlkflknkdslvsnp 90  baker's yeast
XP_002172173   5 SEKNDDFLLPIDPEALQDSL------------------------------------------------------------ 24  Schizosaccharom...
P87306         8 DADISSLSLSLDPEIIGG-------------------------------------------------------------- 25  Schizosaccharom...
CCU77470       6 NTNEDDLLLSLGPDQTPS-------------------------------------------------------------- 23  Blumeria gramin...
EPE26918       2 sTTTNSFPISLRSWPSSK-------------------------------------------------------------- 19  Glarea lozoyens...
Q7SI24        14 iiRTMDSPLNLRPRPPNS-------------------------------------------------------------- 31  Neurospora crassa
EHK45765      54 msSEGGPPLSLRPFPVAD-------------------------------------------------------------- 71  Trichoderma atr...
EON65248       3 TTESSTIQLSLRPAIAEN-------------------------------------------------------------- 20  Coniosporium ap...
CBX99790       2 ssMESLRDVKLRPWPASK-------------------------------------------------------------- 19  Leptosphaeria m...
EPB84714       4 EPTKKRIKLSLEPAIDNNVVditnagqe-------------------------------------------------ilk 34  Mucor circinell...
5SVA_P        91 HEIYGSMPLEQLIPIILRQRGPgfkFVDLNEKELQNEIKQlgsdssdghnsekkdtdgadeNVQIGEDFMEVDY----ED 166 baker's yeast
XP_002172173  25 LAVDSENSLATVIPKIVKKYGL---FRSLTESDLREKSEQeeqsqevq------ekakptpAKQPTAEEQGLD------- 88  Schizosaccharom...
P87306        26 QNNFLENNLQQIFQKIIQERGP---FRDLKEEDLQKELQKesikde---------ssakssETENVLEFATLDSkrnvND 93  Schizosaccharom...
CCU77470      24 ---INENSLADKISRINFQRAEsggFRGLTEDNLREEILGerivtk----------ecsesDGESTEEEEEPDRi----- 85  Blumeria gramin...
EPE26918      20 --NSDATSLSTLFQRINGERGG---IQGLTEESLRQEIAAeaetkm----------deddtSENEDEDEEQPDKl----- 79  Glarea lozoyens...
Q7SI24        32 ---RGPQTIADFIRRVNAEPGG---FRALNEEEVRRNVIAernglhh-------edvemvtDQEADDDSKKPD------- 91  Neurospora crassa
EHK45765      72 ---QKPKNLAEFIARVNAQPGG---FRSITEDKLREELRNsedpd-----------aaddqDEEVSEAAGEADVae---- 130 Trichoderma atr...
EON65248      21 ---NGAHTLAEQIWRINAERGH---FRSVTEEGLRREIEAqeag--------------lveTTEENDKEEEEDKvhtrE- 79  Coniosporium ap...
CBX99790      20 QGTLSQQKLYAQIEQLTTERAH---LRDITKTALQEALGAgkdipd----------gvalkEKEDEEKKEKKEVvtqkVT 86  Leptosphaeria m...
EPB84714      35 tdtslPEKLMQSVDRIWFERGE---WKDISEKSLMASIKKrkqqpel-------kdeeeegEGEEEHELQTENA------ 98  Mucor circinell...
5SVA_P       167 KdnpvdsrnetdhktnengetddnietVMTQE-----QFVKRRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSM 241 baker's yeast
XP_002172173  89 -------------------------------------NLSAHKKELIDQIAMAQNECSLALDMVSLLLSKYRTN-SVDTI 130 Schizosaccharom...
P87306        94 Teve-------------------------------smDSQAYKKELIEQIMIAQTECSLALDMTSLLLSKFKEN-SIETI 141 Schizosaccharom...
CCU77470      86 ------------------------------------kELSIARQELLCQIDSAHQSAMFALDFISLALSKDAPTQAVSTI 129 Blumeria gramin...
EPE26918      80 ------------------------------------rELMEAKGEMLGLLESAYVSSAVTLDFLSLLQSKDNPVQAASTM 123 Glarea lozoyens...
Q7SI24        92 --------------------------------------IIAARHNIIMSLGQAIQISSNFLDFISLLLSKEIPTQAAVSI 133 Neurospora crassa
EHK45765     131 ------------------------------------kDPGVARMEVLKNIDIAGNAALLTLDSMSLLLSKQNPTQAGLTL 174 Trichoderma atr...
EON65248      80 -------------------------------------GLAAARLELIRYVGQAYQEAAMALDMISLLLSKDAPAQGTQSM 122 Coniosporium ap...
CBX99790      87 Re-----------------------------------TIFNAQREMYSHLEWAKFAATNALDLLSLVLSQDPNKRVASSF 131 Leptosphaeria m...
EPB84714      99 ---------------------------LPSQSlppgfDVAKLRESVINKLFHAKSEIDVALDVINILAAGNRGSSAA--- 148 Mucor circinell...
5SVA_P       242 SPF-----LRK-VVKPSSLNSDKIPYV---APTK-----KEYIELDI-LNKGWKLQSLNESKDLLRASFNKLSSILQNEH 306 baker's yeast
XP_002172173 131 SPF-----LEN-AVSLGSLTMNRCEAP------------KAKSSDAL-VGKLWKDKALKNARTSFTAAAQRLRNVVEGEQ 191 Schizosaccharom...
P87306       142 SPF-----LKS-TVPPSSLQFSRSQPP------------ESKESDAT-LAKCWKEKSLTSSCKFLFEAKERLTSVVETEH 202 Schizosaccharom...
CCU77470     130 SSE-----LRE-FVGLGTLGFDKLNAT---RITD-----TKINENKQ-VVRGWQIQSLNKTVDSILAAATRLEKEIESET 194 Blumeria gramin...
EPE26918     124 SQD-----IKL-AVPTGTLGADKLNGP---QINR-----AQMLDNKR-IAKGWKVQNVDKTIDSILNAATRFKNEVESET 188 Glarea lozoyens...
Q7SI24       134 SPW-----LRS-QVPIGSIGATQLDAPt--PLTQ-----SRVADNKL-ITIGKRLVALNEAADTALAAANRLRQEINSET 199 Neurospora crassa
EHK45765     175 SQQ-----LRD-MVGIGTLGADKLNDS---NVTP-----AKTKDKES-VAMGWTLLEINKTRDSSEEAASFLEKEINSES 239 Trichoderma atr...
EON65248     123 SPA-----LKS-LVPPGTIHYEKWPPT---QRTN-----AELRNEDV-VTKGWKMQSLNAAADSLLVGAARLEKEVKKET 187 Coniosporium ap...
CBX99790     132 SHTfreqgLEQ-GIPFGSFGISKESHEyfvPRPEeaerlEELAKKQLlVAKGSRMEALDSAADEILKAAKKLEKEVRRET 210 Leptosphaeria m...
EPB84714     149 --------VKDlVLPAGSLTATYVTKP---KQTT-----KAQLESVQ-LNLGLKRKKQKQASDFLKKSAAALKHLVEKEH 211 Mucor circinell...
5SVA_P       307 DYWNKImqsISNKDVIFKIRDRTSGQK--LLAIKYGYEDSGSTYKhDRGIANIRN----NIESQNLDLIPHsssvfkgtd 380 baker's yeast
XP_002172173 192 EKWNLF---ARFHEKGWPILRGKDG----ALCVQYSALGGQSV-----GVGTFDL----SSKKGKPTFVHG--------- 246 Schizosaccharom...
P87306       203 EYYTEL---VKVKEASWPLFNS-QGSN--HLSVQYSCLGGISL-----GLGLIRM----KPESKSFEVQSS--------- 258 Schizosaccharom...
CCU77470     195 RYWEQV---LDISNNGWAICCLPTEKQ--TLGVRVGISDASPAFK-SRSLAALRR----NHDGSIFLDQGI--------- 255 Blumeria gramin...
EPE26918     189 KYWEEV---VSVSEKGWSLCRLPSERH--TLGVRFGFLEASMTFR-NQSLAALRR----NADGSIFLDQGF--------- 249 Glarea lozoyens...
Q7SI24       200 KYWQEV---LTVSQKGWSTARLPQEPH--DMGVKFGFSNAAPLFK-NNSVAPLKR----AEDGSVRLEYGR--------- 260 Neurospora crassa
EHK45765     240 KYWEDI---VGVKKAGWSISRVPQERH--TLGVRFGFSEAAAEFK-NNGLAPMRR----GDDGSADLDFGR--------- 300 Trichoderma atr...
EON65248     188 KYWEQV---LSLSREGWAIRRVPQQKN--VLGVQIGCVDAAPRFK-SRGFSALRS----NDEGDIILDEA---------- 247 Coniosporium ap...
CBX99790     211 KYWQEI---VSVSDKGWPIQRLRQNARhvPFGVRFGLPEASDHFK-ARGFAPLRM----SKDGSIILDPA---------- 272 Leptosphaeria m...
EPB84714     212 VFWDEA---LDLRRNNWQMQANSNAGA--SFFVQYGYTEVGSDFN-EQSIGELKRssdeDDDGSNLLQMSL--------- 276 Mucor circinell...
5SVA_P       381 fVHSVKKFLRVRIFTKie--------------------sEDDYILSGESVMDrd---------------sESEEAETKDI 425 baker's yeast
XP_002172173 247 -LQYEHASLKVDIHRR------------------------DEIVASNRWSWP------------------DEHKTEEDDV 283 Schizosaccharom...
P87306       259 -LLYSQAALKISILNK-----------------------DRDEIGSSTWSWP--------------------SQNCNSVL 294 Schizosaccharom...
CCU77470     256 -SGSDPQVIRVRI--------------------------ETNGSKTGSTTTP-------------------LLVPDNAPV 289 Blumeria gramin...
EPE26918     250 -TGSEPKILRVRV--------------------------QVGEIYTGTSQVP-------------------KATGEDASV 283 Glarea lozoyens...
Q7SI24       261 -MGSKSERLQATL--------------------------LHNGEVVGRSSLP-------------------RPLPDDAPL 294 Neurospora crassa
EHK45765     301 -LGGVSEALVVTY--------------------------EKDGKVIGRSTTR--------------------PSSDDESL 333 Trichoderma atr...
EON65248     248 -LTQRPEAIRVRI--------------------------RHQDKIIGSSRLA------------------AIDTKAQAPV 282 Coniosporium ap...
CBX99790     273 -LALKPKTFRVRV--------------------------TLDGETTGTSQLS------------------VQQDMKDNSI 307 Leptosphaeria m...
EPB84714     277 -PHGTCRKVAVRISKShmgklglggqnefsegilgileeQQGAYAADQDKERstfnqgkeggaavkvysnTMLGTSHSKI 355 Mucor circinell...
5SVA_P       426 RKQIQLLKKIIFEKELMYQIKKECALLISYGVSIENeNKVIIEL---------PN------EKFEIELL---SLDDDSIV 487 baker's yeast
XP_002172173 284 EKQLHQARRTLFEMDVWNALLLEAQYCGNQGVIYTG-NSIEVTYd--------GT------YKTSISLS---PVDSGADE 345 Schizosaccharom...
P87306       295 LKDIYKLQEILFEMDIWNSLLQEAQSCGNQGVNFTG-DEILVPI-----------------SDDHVVRI---TLETSSKN 353 Schizosaccharom...
CCU77470     290 QALILQARNTLFAEELWQELQREARFLCSFGVSSTS-STVTLTLt--------PQ------KRALIDIV---PLCAQSIS 351 Blumeria gramin...
EPE26918     284 ESLIQQARNTIFFTELWQELNRESRNLGGADVKATE-DSLILPLn--------SE------KRIILDLVniaDLEAPAPQ 348 Glarea lozoyens...
Q7SI24       295 DDRVKEARNTIFAQELWHEINREGRTLHGHHVRLEQ-SAVTCALd--------PN------RTISFELV---GLDDQDHS 356 Neurospora crassa
EHK45765     334 EARVLEARNTIFSQELWHELTKESRSLAAYDVKPEG-RKLACQId--------ET------TKITLELL---PLESCPSP 395 Trichoderma atr...
EON65248     283 EELVHRARDTLFEQELYQEMILEARQLHGYYIETRD-GVINVPAkspkasntiPDgskevtEHILIDKV---YLDETLDD 358 Coniosporium ap...
CBX99790     308 EKSIQLARDSLFEEELYHEMSMETRQLLAYGVEFRD-SVIQLDVprmgn--------tsqqLKLLIDCI---PRDEPIAE 375 Leptosphaeria m...
EPB84714     356 QNQLAEAHSTVFDAELFSDILAEAQALNS-NVRFPD-DEIVINId--------GQ------IDLHVSKV---------PV 410 Mucor circinell...
5SVA_P       488 NHEQDLPK---INDKRANLMLV------------MLRLLLVVIFKKTL-------------------------------- 520 baker's yeast
XP_002172173 346 HH---------KNDLSSDSMNVddkdvqlrelclVFNTLIHVLFVQYC-------------------------------- 384 Schizosaccharom...
P87306       354 TESGFTEDkksNEDTSTNFVTIkqekellkclcdTLNAIAHILFLKHC-------------------------------- 401 Schizosaccharom...
CCU77470     352 ESRG-------KDDFFASGIHT------------ALHLGLTWSHRLVR-------------------------------- 380 Blumeria gramin...
EPE26918     349 -----------EDDHIAQGLCL------------SLQLLLSYAHRQNH-------------------------------- 373 Glarea lozoyens...
Q7SI24       357 RAPL-------PGDLDAETASI------------TLHLLLSNAHRQNQ-------------------------------- 385 Neurospora crassa
EHK45765     396 EQDM-------PENGLAEKISM------------ALHILLSYAHRYNE-------------------------------- 424 Trichoderma atr...
EON65248     359 YDGH-------TQDAFAERVAL------------ALRVLLAHGYRQRL-------------------------------- 387 Coniosporium ap...
CBX99790     376 SQSQ-------SHNWLAQNVAE------------GLRLLLAHEHSMRL-------------------------------- 404 Leptosphaeria m...
EPB84714     411 VAANHTPAkltSQQIISRSIDL------------SFRLLLLQHQRFNLwktkakilssnhkihqllsdtavgsstassaa 478 Mucor circinell...
5SVA_P       521 -----------------------------------------------------RSR---ISSPHg--LINLNVDDDILII 542 baker's yeast
XP_002172173 385 -----------------------------------------------------RET------QKfslKHLRQNPIPASIL 405 Schizosaccharom...
P87306       402 -----------------------------------------------------RKSdrrSQQPElymAIDANAP---LIL 425 Schizosaccharom...
CCU77470     381 -----------------------------------------------------RRRa-qPPQPVt----SNPLPEPCSLM 402 Blumeria gramin...
EPE26918     374 -----------------------------------------------------RRRt-lPPPPIsgqKRTNP---PYNLL 396 Glarea lozoyens...
Q7SI24       386 -----------------------------------------------------LKR-----SERtaaNAMRGPPPPYNLL 407 Neurospora crassa
EHK45765     425 -----------------------------------------------------LMRirpIPPHIsrsTRQQS----YALL 447 Trichoderma atr...
EON65248     388 -----------------------------------------------------HLRs-qVPPPMtdkERK---PPVTAIL 410 Coniosporium ap...
CBX99790     405 -----------------------------------------------------YRRs-qVPPPLtarAQEKPPPP---LL 427 Leptosphaeria m...
EPB84714     479 tpvnttattnaptptnsgngatgapaptpttatsgnvlpivgtsssvstasraRTR---LAATAttaTATRDLPSQIPIL 555 Mucor circinell...
5SVA_P       543 RPILGKVRFANYKLLLKKIIKDYVLDI 569 baker's yeast
XP_002172173 406 RPLIFLFSTNRLAHSFQTWLQEHnipf 432 Schizosaccharomyces japonicus yFS275
P87306       426 RPLIFYYNLNQESLEFQRWLKQRDISF 452 Schizosaccharomyces pombe 972h-
CCU77470     403 RPILTRLVHERTISEVIAFISPLTASL 429 Blumeria graminis f. sp. hordei DH14
EPE26918     397 RPIITRLGHQRTVNTLTTLLRDLTSLL 423 Glarea lozoyensis ATCC 20868
Q7SI24       408 LPIITYYRHEKTLEDCTTFLAAFCGAL 434 Neurospora crassa
EHK45765     448 RPVLARTMYLKNVEESMQNMGLLVRTL 474 Trichoderma atroviride IMI 206040
EON65248     411 RPLLTVLQHWRDVGLLREYLKTTCTAR 437 Coniosporium apollinis CBS 100218
CBX99790     428 RTLLAVFRHLESVDSLYVYLETLKRTL 454 Leptosphaeria maculans JN3
EPB84714     556 SPIMSLTRFWVQFDRIRHVTNKTIREY 582 Mucor circinelloides f. circinelloides 1006PhL
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