Conserved Protein Domain Family
McrBC

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pfam10117: McrBC 
McrBC 5-methylcytosine restriction system component
Members of this family of bacterial proteins modify the specificity of mcrB restriction by expanding the range of modified sequences restricted.
Statistics
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PSSM-Id: 370821
View PSSM: pfam10117
Aligned: 19 rows
Threshold Bit Score: 249.901
Threshold Setting Gi: 500075466
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7VG80           75 NYVGLIQAKsGF-----CVEILPK--TFRTAK-----------KNegfkiqnctckktqdttkqpqnmesnppkckvcea 136 Helicobacter...
tigr:NT01CX1426  57 NYVGYIKLS-TV-----DIEILPK--ISINEEnp--------eIE----------------------------------- 85  Clostridium ...
Q188G2           58 NYVGIICFE-NV-----ILEILPK--LSLSDNlv--------------------------------------------kd 85  Clostridioid...
Q8CYQ4           80 NVIGFLGYGqE------RLTISSR--FSDESN------------------------------------------------ 103 Streptococcu...
Q8TP09           70 NYIGFIHFE-NS-----NIEIYPK--VFQN--------------Elkepetr----------------------kikelm 105 Methanosarci...
Q5JH86           66 GSVGFAYYLgDDgi--vLVQVLPK--PFRYDRe----------------------------------------------d 95  Thermococcus...
Q5JJA9           60 PYVGFVLYKdKTsgkihQINIYPK--IFLGGLsse-------------------------------------------ds 94  Thermococcus...
WP_011751479     49 HAVGAVRRGdL------VVRVTPK--VGAAKV------------------------------------------------ 72  Nocardioides...
jgi:Arth_0863    62 GMVGSVRTPtV------QLEVRPKdrLGLSRL------------------------------------------------ 87  Arthrobacter...
Q4FV58           77 HYIGVIVMPsGM-----ILEILPK--LIGNTAssptqqscqpnKPladtd--------------------------ifqt 123 Psychrobacte...
Q7VG80          137 KALLLKMLQ-----------SLKDSPFKQSHFAHLKLTKM-PLLEIFILM--FLQELEKLVKKGLKSDYIVCEENRNFLK 202 Helicobacter...
tigr:NT01CX1426  86 RKALLNMLS-----------ICGILNISYSDISLSNIYKM-NLNEILSFL--FAKNLQKELIKGIYQEYIYVEKNNNLLK 151 Clostridium ...
Q188G2           86 REILLQMLS-----------ICNKIPITMNEKIRLSLKNY-NLLNFFVMY--FIESMQTQMKKGIYFEYINKIENLNVMR 151 Clostridioid...
Q8CYQ4          104 DHFLHYLLN-------------KVLYINLTSLDVALSREE-RLYQLLMYL--FPKYLQAAIRKGLYKEYHRFSHNDSNVK 167 Streptococcu...
Q8TP09          106 HRHLFYWFS-----------YCRKVKFPFNQ-ASLDRFDF-ELPELILYL--FAKQICEVISLRPYSAYEEVQEALFTPR 170 Methanosarci...
Q5JH86           96 GRSLLFFLQlfn------myYQMGLEPGEIRALVFEYGRQkALDEIFKYL--YVLMLSRALSRGLYYEYGEIEESSQTVR 167 Thermococcus...
Q5JJA9           95 WKIVLKIADl---------yYNLGLREYDIKTALATEGNS-PFIDILLDI--FSNRLLNELRFGIYGEFVSTEETSSSLR 162 Thermococcus...
WP_011751479     73 ----LTLLA-----------RAQGVRGLKVDPELVGVAPHaDISAVLAVL--FAQEAATAMAAGPLRGYRSEDQTLPVLR 135 Nocardioides...
jgi:Arth_0863    88 ----LFLLS-----------YAGNQGFREDPVAAVEDPDL-----WSALAvsLVQLADRALSRGVLQGYLTVDESLRTVK 147 Arthrobacter...
Q4FV58          124 RHWVQNMLSdlmnsdddkspHSKNFGQFSSPLIALPVAAL-PLSDWL-----ITQFLQRLAHHQPITHYQTQIHNQTALQ 197 Psychrobacte...
Q7VG80          203 GKLLFHQNLKLNF-AHRERFFTSSDEFSVNIAPNRIIKSTLELLNTQN------------LSTNTSA--KLMQMRFIF-- 265 Helicobacter...
tigr:NT01CX1426 152 GRILIQQHIKNIA-SHTPKVFCGYEEFSVDNKLNQILNYCINILIKNV------------KNQETIK--SLRYAQACF-- 214 Clostridium ...
Q188G2          152 GKILLSTYAKEKG-ISPMKIRCEYDEYSENNFLNQVLKKACISILCRI------------NDNSIQG--KIKKILSYF-- 214 Clostridioid...
Q8CYQ4          168 GVIVVRNHLKKNL-PFTGNIAYTTREFTYDNPLMQLVRHTIEYIKNQKsigqg---vldnLSTSRENvsEIVRVTPSY-- 241 Streptococcu...
Q8TP09          171 GRINFDRYAARMScGNYHMIDCDYEPFIFDNLLNRTIKYCTRLMLSKT------------RVIETQR--ILNEIIFML-- 234 Methanosarci...
Q5JH86          168 GRILV-NELARRP-AWKADLPVRYSLLLEDNPLNRVLKGALEVAVKSA------------RLSETRK--VGGILLDLF-- 229 Thermococcus...
Q5JJA9          163 GQLLVEREILKLP-TQKHKFDIRYKKFTVDNFLNRVFKYTLYLGLQHT------------NRRETKR--TLSEAWDML-- 225 Thermococcus...
WP_011751479    136 GRVRLREQHLRRF-GLPVPLEVTVDEWTLDTDDNRRTRAAATALLALP------------GVPEHSTq-ALRRLDRLL-- 199 Nocardioides...
jgi:Arth_0863   148 GRIRISDQISRRP-GMLVPLEVSYDEFTEDIAENRILRAALERMARVP------------RVRPDVQs-RLRLLLGKL-- 211 Arthrobacter...
Q4FV58          198 GRLLIKEQLRHNS-MQPHKFVCERSVLSKGMLANRIIKSALKLLAPLLsqsnlllylqpwQQVSVLHqyEIRQLASIYfq 276 Psychrobacte...
Q7VG80          266 --LDIPPSQSIDKDLSKCQNLGYFRNYKMILQWCEIFLKR--KSFAPYQKDS-KAYALLFDMNKLFESFVAsemkKWLCd 340 Helicobacter...
tigr:NT01CX1426 215 --VDITQRKINNDEILSYKFNRLNNRYKQVFELAKMIIMG--YSSLGSGVDK-KTYGILFKMNDVFEKYIE----KVLY- 284 Clostridium ...
Q188G2          215 --QNVDLIHIDRKKLLDYKFYKNNDRFKDCYLLARLLLLN--LSMDNSQNNQ-EAFSILFEINTLYEEYIG----ILIKs 285 Clostridioid...
Q8CYQ4          242 --KLADRAKITRRNQSKPIRHAYFHEYRNLQELCLMILNQ--EKHGLGYQDQ-KIYGILFDVAWLWEEYVY----TLLPk 312 Streptococcu...
Q8TP09          235 --DEVDDRVCSVQQLQTIRIPSMYSDYEDVIQICCMILKN--QVYSYQEYEF-KNWSLLFPMEYIFEDFIS----GYIRk 305 Methanosarci...
Q5JH86          230 --RDVGDPK--PGDFGKVSFNHLNERFRTVFRLARVMYFG-----LAAGGSRkFLPGVFIRMDELFETLVY----RTLKt 296 Thermococcus...
Q5JJA9          226 --KEVSLTPISVDSIEKLTLNSLNLRFELPLKLAKIIISG-----LDYQKGL-ISPGFIIPMPDAFEFFVY----KLLRa 293 Thermococcus...
WP_011751479    200 ---GEAKLLAPGAPLEPWTPTRLNVKMHRLLHLADVVLAH--TSVEHEAGAT-QTHGFVVNMAWLFETLIA----RLLE- 268 Nocardioides...
jgi:Arth_0863   212 --DAVTRLR-PGAPLPPWQATRMNTRYHAVLRLSEVILRN--ASAEAGDGKQ-QTASFVVDMGQVFEDFVG----TALRe 281 Arthrobacter...
Q4FV58          277 akHELAIQPLQAQQLQAAQQLVDFAYWLLCQSHAETGHSIdsQNPFHKKLTP-QRLCLLIDMNQAFEQWASqriaLFFQ- 354 Psychrobacte...
Q7VG80          341 mklsyenkvfieqifrESKKDSYLKTQEKSKY-LIVE-GDKNR------FLLNPDIvgYQKQTKETF------------- 399 Helicobacter...
tigr:NT01CX1426 285 ----------------TNLEDSIVHYQHSKYK-LLVN-EDTEKk----vFKLIPDI--VIEKDGIER------------- 327 Clostridium ...
Q188G2          286 ---------------iWDNSFRETYIQDKSKF-LLKN-EQTGKk----nFNLRPDIv-LYDLKNEYE------------- 330 Clostridioid...
Q8CYQ4          313 ---------------gFVHPRNKDKTDGISVFsVGKR-------------KVYPDF--YDRERK---------------- 346 Streptococcu...
Q8TP09          306 ----------------HFSNTFKVEPQKSDLY-LHTS-PNT--------FNLQHDIl-LTNKKTEEQ------------- 345 Methanosarci...
Q5JH86          297 ----------------VLDNEAEVRFQVQLPH-VIKN-AGEIEarfgalFMMGNPLpdIVVSTDEGT------------- 345 Thermococcus...
Q5JJA9          294 ----------------ILGKDYRVRYHPQNREfVLETpRKFIE------NPPQPDIi-IESSSGQp-------------- 336 Thermococcus...
WP_011751479    269 ------------------EQTLGLVPQQTMPLdTLGR------------LSIKPDL--LFDGPGGVV------------- 303 Nocardioides...
jgi:Arth_0863   282 ---------------aMTAYPGEMRLQYNALLnEAVRdSDR--------LTVNPDAvhLLGGRPV--------------- 323 Arthrobacter...
Q4FV58          355 ----------------QLSDDYKPLFQTQRVW-LNDA-EGQAC------LSIRPDL--LIYKQIHSSaentamydnyvsq 408 Psychrobacte...
Q7VG80          400 -------------FIADTKWKILSKE----QQNYG--VSQS-DMYQIFAYLAKYQCNQGF------LIYP 443 Helicobacter hepaticus
tigr:NT01CX1426 328 -------------IIIDTKWKSVSNE----YNRHG--VKRE-DIYQMYAYLTRYQNVNTAi-----LLYP 372 Clostridium novyi NT
Q188G2          331 -------------IIIDTKWKAIEV-----DSNVF--YRSS-DIYQMYAYITAYENAKRCi-----LLYP 374 Clostridioides diffici...
Q8CYQ4          347 -------------IVLDAKYKKLE------LTEKG--INRE-DLFQLISYSYILKAEKAG------LVFP 388 Streptococcus pneumoni...
Q8TP09          346 -------------IIIDTKYKPRWNLek-cDSKKG--IAQT-DMYQMISYA--YRRGTDKv----lLIYP 392 Methanosarcina acetivo...
Q5JH86          346 -------------CVVEVKYRNLYVYhrgeNRAHRklVRKSdELYQAYTYSRLVSEYLGAkrvpvlLVYP 402 Thermococcus kodakaren...
Q5JJA9          337 ------------lVVVDAKYKTLYCPkcgeKQRYV--KNSS-DLYQIYSYTKLYNAHAGV------LVYP 385 Thermococcus kodakaren...
WP_011751479    304 -------------AVADTKYKLLDDNg---------kVPNA-DVYQLVTYCARLGLSTGH------LIYS 344 Nocardioides sp. JS614
jgi:Arth_0863   324 -------------VVYDTKYRA--------ATDQG--ASLSaDHFQMLAYCTALRVPTAW------LVYA 364 Arthrobacter sp. FB24
Q4FV58          409 akdarekhsrhysHVIDIKWKHL-------AHASA--ISAS-DAYQLSSYAQAYQAEQVW------LVYP 462 Psychrobacter arcticus
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