Conserved Protein Domain Family
Fibrillarin_2

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pfam10113: Fibrillarin_2 
FeGP cofactor biosynthesis protein, fibrillarin family
Members of this family of proteins include archaeal fibrillarin homologs also known as HcgG which is involved in biosynthesis of Iron-guanylylpyridinol (FeGP) cofactor.
Statistics
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PSSM-Id: 401927
Aligned: 12 rows
Threshold Bit Score: 816.238
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Mvol_1347   1 MKELIKDSINDPMAALELKGIinnklirnklkESDIIEIVDVLGNFELEELYKIGNNFRKFPMGCDLVELGVGPCSSTLD 80 
ABN07906        1 MKSLLQDAANDPYRAWELVKY-----------AKNPEQIIEGLTALNREETMHLGMNFKKFPLGCDLTEVFVGTCASDLA 69 
Q2FR47          1 MHDLIRKAINDPDAAWELSKI-----------EKGPRDVIDAVTSLNREEAIKLGNTFKRFPLGCDLTEILVGTCASDLE 69  Methanospirill...
WP_015284886    1 MSDIVREAARNADAAWELSRM-----------KKDPAEIVSAVSELHREEAIALGNNFKRFPLGCDLTEIFVGTCASDME 69  Methanoregula ...
O27209          1 MHELIREAVDNPGTAWEIIKM-----------DRDVTEVVDAVSDLSREDKIKLGATFKRFPLGCDLTELIVGTCASDLE 69  Methanothermob...
jgi:Mfer_0723   1 MHDIVKEAVNNLDAAWELAKM-----------KKTPEEIVDAVSDLSREETMQLGKNFKRFPIGCDLTEILVGACASDIK 69 
Q8TZB8          1 MLDLLHEACESLDAALELKRLay-------egKLSVDEVVTDLGELTDRELEALGDNLRTFPMGCDLIELAVGPCASDYS 73  Methanopyrus k...
Q58197          1 MRELIKEAVNSLDSALELRKLiikklnekklkESDIIEIVDAVDDLSLEEIQKLGSNLRTFPMGCDLVEIAVGPCSSSLT 80  Methanocaldoco...
jgi:Maeo_1028   1 MHDIIKSAVNDLDACLELRGLitnkltnnkltEGDIISVVDAVGELPIEDIQKIGSNLRKFPLGCDLVEIGIGPCSSSLT 80 
WP_012955327    1 MYELIKESINSDESALELAKS-----------KKDVISVVDAISDLSFEDTMKLGTRFKKFPIGCDLTEVVVGTCASDLE 69  Methanobreviba...
WP_016357633    1 MYELIKKAVNSDEAAIELSKM-----------DKDVTEVVDAISELSLEETMKLGTRFKKFPIGCDLNEIIVGTCASDLE 69  Methanobreviba...
jgi:Mpet_2001   1 MYDLVKKAVLDPYAAWELSKM-----------DKSPAEIVEAVSRLDRDEAMKLGMNFKRFPLGCDLTEILVGTCASDLD 69 
jgi:Mvol_1347  81 LRQFLENCTLTDHMGFPIHLCAYAIADIAEKESMTPFEVMEKIYNLVDVPLDLDHFGENGPMRFPKEITHCMGECYNQGP 160
ABN07906       70 LQDIYGNCLLSDTIGASIHVCAYAFSDIAEANGMRGIDLMRKIRETTEVPLDLDHFGMYGPMRFPETIVGCPGQCYNQGP 149
Q2FR47         70 KTDILGNCMLADSIGASIHVCAYAFADIAEAHGMKGIDLLKEVREITEVPLDLDHFGRYGPMRLPPQIIGCNGQCYNEGP 149 Methanospirill...
WP_015284886   70 KIDILGNCQLSDAIGASIHVCAYAFADIAEAHGMKGIDLYREVRELTEVPLDLDHFGSFGPMRLPKDIIGCQGQCYNTGP 149 Methanoregula ...
O27209         70 KIDLMGNCMLSDTIGATIHVCAYAFADIAESYGMRPVELMREVRETTEVPLDLDHFGRYGPMRFPRSITGCGGQCYLEGP 149 Methanothermob...
jgi:Mfer_0723  70 KIDLLGNCIVADMLGASIHVCAYAFADIAENYGMRGVDLVKEVRELVDVPLDIDHFGKYGPMRFPSDITRCWGQCYYEGP 149
Q8TZB8         74 PDVLLANAILADRMGLPLHVCAYAVADVAENYGMRPIELFRRLVRNVRVPVDVDHIGAHGPMRFPRDITACEGTCYLEGP 153 Methanopyrus k...
Q58197         81 LIQFIENCILTDYMGFPIHICSYAVADIAEKEGLKPIEVLKMVLENVDVPIDIDHFGMYGPMRFPKEITHCYGDCYFKGP 160 Methanocaldoco...
jgi:Maeo_1028  81 MPQLVENSMLSDYMGFPIHICAYALGDIAERESITPLEVFKTISESVEVPIDLDHFGKYGAMRFPKEITHCGGDCYRMGA 160
WP_012955327   70 KMDLFGNCMLANMIGAPIHICAYAFSDIAEKYGQRGVEIMEEVYNITDVPLDLDHFGKYGAMRFPKHIVGCGGDCYNQGP 149 Methanobreviba...
WP_016357633   70 LKDLLGNCRLANMIGSPIHICAYAFADIAENNDMRGIDVMKKVHDTVDVPLDLDHFGENGPMRLPKNIVGCGGECYYKGP 149 Methanobreviba...
jgi:Mpet_2001  70 KIDILGNSILSDSIGASIHVCAYAFADIAEANGMRGIDLFREVRENTEVPLDLDHFGKFGPMRFPKDITGCWGQCYNEGP 149
jgi:Mvol_1347 161 PYTGCPKDRIHKRLLDKEHKYAYEFENWIKKSSTVCVNVVKE--QGGEEHSASIDEMEKVVKASKKFGKGIEGIFHIGDG 238
ABN07906      150 PFDGCPRGRIHARLIEKEKEALEDKEEWIKLSSSVAVNLTSI--QGGEEHAASLDEAEDIVKLARKYNKGIEAIMFVGDG 227
Q2FR47        150 PFSGCPRDRIHSRLLDVEQDALSDRDEWVKISSSVAVNLTCV--QGADGHAAPLDEAQEVADLARKYGKGIEAIMFVGDG 227 Methanospirill...
WP_015284886  150 PFSGCPRDRIHSRLLDKEKEAIADREEWVKISSSVAVNVSCV--QGAQGHAAPLEEAREIAELAIKFGKVVEAILFVGDG 227 Methanoregula ...
O27209        150 PFEGCPRERIHARLLDREKEGLSDREEWVELSSSVAVNLTPV--QGAETHAAPLEEAEEVLELARKHGKGVEAIMFVGDG 227 Methanothermob...
jgi:Mfer_0723 150 PFKECPRGRIHKRLLEKEKKGIKERDEWIKLASSVAINLISV--QGGEAHAAPLDEAIEVAKLTKKYGRGLEAIMCVGDG 227
Q8TZB8        154 PFKECPRGRIHRRLIDKERQQGEDLEEWAELAASICVNVTGEggQDAEAHAAPLDEMKRVAETARHSGAGVGAILHVADG 233 Methanopyrus k...
Q58197        161 PFKGCPRNRIHKRLIEKEKEHADEFEDWIKLASTLCINVVEE--QGGEEHAAPLEEMKIVAETAKKYGKGLEGIFHIGDG 238 Methanocaldoco...
jgi:Maeo_1028 161 PSEGCPRGRIHKRLIDKEKEYSYEFNDWIKLSSTVCINVVEE--QGGEEHGAPLEEMKIVANEAHKHGKGLEGIFHIGDG 238
WP_012955327  150 SFTECPRGRIHERLLDKEKAELDDKETWVQLSSSVAINLSSE--QCNDGHAAPLEEAQDLADLAKKYGKGLEAIMFVGDG 227 Methanobreviba...
WP_016357633  150 AFTECPRGRIHERLIDKELKEKSDKEEWVKLSSSVAINLSSV--QSGEGHAAPYAEAVDVANLAKKYNKGLEAIMFVGDG 227 Methanobreviba...
jgi:Mpet_2001 150 PFDGCPRDRIHSRLIDKEEDALGEKDEWIKLSSSVAINLTCI--QGAEGHAAPLDEAIEVAQLGKKYGKGIEAIMFVGDG 227
jgi:Mvol_1347 239 YDDLITGLTACN-DLDVDVFVVEGGPFNRSNDRLKDFAKSIVASRILVRGGVVATNGAYEDECRVGLRSGLNVILTGFVG 317
ABN07906      228 YEDLIAGFDAGL-KMGVDVFVIEGGPFNRAKDRLDAFSRAVTAARILAPGKVVATNGAYEDECRVGLRSGLNAVISGFPK 306
Q2FR47        228 YDDLIKGFTAAL-DMGVDVFVLEGGPFNCSTDRLTAFARAVAIARILVPGKIVATNGAYEDECRIGLRAGLNAIITGFPK 306 Methanospirill...
WP_015284886  228 DEDLLRGFTAAL-ELGADVFVIEGGPFNCAKNRLDAFARAVAAARILAPGKVVATNGAYEDECRIGLRAGLNAIITGFPK 306 Methanoregula ...
O27209        228 YDDLISGFEAGL-EMGVDVFVLEGGPFNLAGDRLDAFAGAVAAARILTPGKIVATNGAYEDECRIGLRAGLNAIITGFPK 306 Methanothermob...
jgi:Mfer_0723 228 YEDLIKAFEAAL-EIGVDVFVIEGGPFNQAKDRLDAFARAITCARILAPGKVVGTNGAYEDECRIGLRSGLNAIITGFPK 306
Q8TZB8        234 EDEFADGLKAAVeEVKADYLAVEGGPFNRAEDRLSAFRRAVVACRVFAPGKVVLTNGAYEDELVVGLRAGLNGALSGFPK 313 Methanopyrus k...
Q58197        239 YDDLITGIKACI-DLDVDVFVVEGAPFNRAKNRLKAFAKAIAVSRILVKGGVVATNGAYEDECRVGLRSGLNTILTGFPL 317 Methanocaldoco...
jgi:Maeo_1028 239 YDDLITGLKSCV-DLGVDAFVVEGAPFNRAKDRLKTFAKAIAVSRILVKGGVVATNGAYEDECRIGLRSGLNMILSGFSG 317
WP_012955327  228 YDELITGFTKAI-EMGVDVFVIEGGPFNRCENTNESFAKTIAMSRVLCPGKVVATNGAYESECRAGLRSGLNVIITGFPK 306 Methanobreviba...
WP_016357633  228 YDELITGFEKAI-DIGADVFVIEGGPYNRAENTTEAYAKAIAASRILCPGKVVATNGAYEHECRAGLRSGLNMIITGFPK 306 Methanobreviba...
jgi:Mpet_2001 228 YEDLIKGFTTAI-DMGVDVFVIEGGPFNLAENRLDAFARAIAMARILVPGKIVVTNGAYEDECRVGLRAGLNGIITGFPK 306
jgi:Mvol_1347 318 NHHGYMCGYAPGTAKRTNFGLPRVLSIVKEEL-S--NLNICLATKTQLEAIAKGNKFLtynDKTYIYPETVGNYFMGDAH 394
ABN07906      307 NHHGYMCGYSPGTAKRGNFGLPRVMQIIHDEA-At-QWTHAPIQKGELEALARAVKVV---GPQNAYPKVIGATTLGDAH 381
Q2FR47        307 NHHGYMCGYSPGKIKRGYFGLPRILQIIKEEV-Rd-RWTHTPIQKGELEALARAVKVV---GIDTVYPQKIRYTYVGDAH 381 Methanospirill...
WP_015284886  307 NHHGYMCGYAPGTARRGNFGLPRVLRIIREEV-Rd-GQTRAPIMKEEVEALARAVKIV---GPEHVYPEKIGDCAVGDAH 381 Methanoregula ...
O27209        307 NHHGYMCGYTPGTARRGKFGLPRVMKIMREEV-Es-GLTPVPIQKAQLEALAAAVKVS---GTENVYPRTLGYTYVGDAH 381 Methanothermob...
jgi:Mfer_0723 307 NHHGYMCGYSPGTARRGNFGMPRVIKIIKEEV-Kn-GLTRAPIQKDELIALTKSVKVI---GKENIYPNKIGYTTVGDAH 381
Q8TZB8        314 NHHGYMVGYEPGTARRGKFGLPKVLAIMRKTLgSryGNTKVPAGWEELEGITRAALFL---GSNLLYPRDVAGIPIGDVH 390 Methanopyrus k...
Q58197        318 NHHGYMCGYSPKTAKRGNFGLRRVMRIIKEEI-RagNVNATFIDKDMVKAIALGNRFL----KGNIYPYSIGGFYLGDAH 392 Methanocaldoco...
jgi:Maeo_1028 318 NHHGYMCGYSPDTAKRGNFGAPRVLRIIKEEI-EynKLDTCLLTKPVLRALTKSAKFLnygGNSLIYPNKIGDFFTGDAH 396
WP_012955327  307 NHHGYMCGFEPGTARRGKFGLPRVIKIMNEEI-Sa-GPTRVPVQREELLALTHAVKLA---GPENIYPKTIGSFAIGDAH 381 Methanobreviba...
WP_016357633  307 NHHGYMCGYEPGTAKRGNFGLPRVIEIMNEEV-Nn-KYTRVPIQREELIALATSVKIA---GPENIYPKKIGSYTVGDAH 381 Methanobreviba...
jgi:Mpet_2001 307 NHHGYMCGYSPGTARRGKFGLPRIIRIIKEEV-Qe-DLTKAPIQKDELESLARAVKVV---DPVNVYPRKIGFAPVGDAH 381
jgi:Mvol_1347 395 WTTVKDSNLGRKPYFG-KNLTSLGEELGN---YDKLGLLGARYISWGIANNLN---PEEVYISDMDPWVEKATVKILNDN 467
ABN07906      382 WACLSHTPLYRRVTVN-RTINDITQMAENgefNETVALLGGRFVSWAVAKALSg-kVDRILISDADPWVENITIENLRSV 459
Q2FR47        382 WACLPHTPVFSRTHVL-KTVQDIVSMALDgqiGDTVALLGGRFVSWAIAKKLDg-vVDSIIISDVDPWIEHVTIDNLRSE 459 Methanospirill...
WP_015284886  382 WVCLQSTPLYHRVGIS-KTAAGISSMAKEgllGDTVALLGGRFVSWVLARELEg-yVDRIIISDTDPRVENVTVENLRGA 459 Methanoregula ...
O27209        382 WACLPSTPLYERVEVK-RDVNALVKMAEDgdiHGRVAIFGARFVSWVIADKLDg-lVDEFVIVDRDPWVEQVTVDNLRSE 459 Methanothermob...
jgi:Mfer_0723 382 WVCVSLTPLYEKLHVN-KTVDDIVKMAENgliGEKVALLGGRFIAWVLAKKLDk-yVDQILISDVDPWVEKITVENLRSE 459
Q8TZB8        391 WVAALRSNAARELSDEvRSVEEVASEVD----ADTVALLGGRFPAWGLALTLDelgVSEVLISDPDAWVERATVRLLDEE 466 Methanopyrus k...
Q58197        393 WAAIKESNLCKKLKIN-KTIDDIS--------AEKVGLIGGRYISWAIAEK-----AEEVYISDTDSWVEKATIKILNEA 458 Methanocaldoco...
jgi:Maeo_1028 397 WVAVNNSNLANNLHT--KTIDDIEK-------VDKIGALGGRYVAWGLIDALK---PEEVYISDANKWVEYATIKILNDA 464
WP_012955327  382 WATIQNSKMYKEMYLP-KTLEEIADSVN----GNSVSLHGGRFVSWLVAKELDkkgIDEIIITDSNPWVEKVSVDNLQEE 456 Methanobreviba...
WP_016357633  382 WATLTSSRIYDNINLK-HDLNSIVESVN----GSSVALLGGRFISWVIAKELDk-qVDEIIISDVDPWIQNVTVDNLQEE 455 Methanobreviba...
jgi:Mpet_2001 382 WVCLPSTPIYERVTVK-RTVHDIRKMAEEgkiGDSIALLGGRFASWVIAKELEg-yVDQITISDIDPWVEKISVENLQSE 459
jgi:Mvol_1347 468 -GINAYACDGNDKKVVENSDKSVITTMIPEIMIKILKKT--NAIN 509
ABN07906      460 vDTEICSGNTDDAGSAASADSTIICSTVPEIAGKIQHKIgrNAIT 504
Q2FR47        460 lHTEISPAKSSDTYAHEHADTSIICSTMPELVRKMSWKCg-DAIT 503 Methanospirillum hungatei JF-1
WP_015284886  460 lRMDIEQGGSDDRLSASRSDAAIVCSTIPSINRKISLGVr-NPIS 503 Methanoregula formicica
O27209        460 lRTDVHPGNSDDEGAYSSADSSIVSTTIPQISAKISGKFr-DTVT 503 Methanothermobacter thermautotrophicus str. Delta H
jgi:Mfer_0723 460 iKADVHRAHSNDKEAYNESDATIISSTIPGVVRKLTKKLp-ESVA 503
Q8TZB8        467 lDATVHAMAGDDRKAVKEADAAFVTAVMPGIAERLAERT--GAMT 509 Methanopyrus kandleri
Q58197        459 -GINAYPCNGDDKKVLE-ADKAYITTFIPNIALKILNKL---RDS 498 Methanocaldococcus jannaschii DSM 2661
jgi:Maeo_1028 465 -GINAYGTDGNDKKVIEQADKSFITSFIPEINLKIKNRY--NKdv 506
WP_012955327  457 lNATIIRGHADDKGAGMIAKESIVTTTIPKIHNAIKSKIp-HAVN 500 Methanobrevibacter ruminantium
WP_016357633  456 lDATIIKGDG-DVNSSEKSDDTIITSTIPNISNKILNKVp-DAIN 498 Methanobrevibacter
jgi:Mpet_2001 460 lKANIYTGNSDDNAAYKNSETAIVCTTIPSISNKISKNLn-DAIT 503
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