Conserved Protein Domain Family
LIN52

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pfam10044: LIN52 
Retinal tissue protein
LIN52 is a family of proteins of approximately 112 amino acids in length which is conserved from nematodes to humans. The proposed tertiary structure is of almost entirely alpha helix interrupted only by loops located at proline residues. Three sites in the protein sequence reveal two types of possible post-translation modification. A serine residue, at position 41, is a candidate for protein kinase C phosphorylation. Glycine residues at position 69 and 91 are probable sites for acetylation by covalent amide linkage of myristate via N-myristoyl transferase. LIN52 is differentially expressed in the trout retina between parr and smolt developmental stages (smoltification). It is likely to be a house-keeping protein. LIN52 forms a complex (LINC) required for transcriptional activation of G2/M genes. The LINC core complex consists of at least five subunits including the chromatin-associated LIN-9 and RbAp48 proteins. LINC associates with a large number of E2F-regulated promoters in quiescent cells. Family members are required for spermatogenesis by repressing testis-specific gene expression.
Statistics
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PSSM-Id: 401871
View PSSM: pfam10044
Aligned: 26 rows
Threshold Bit Score: 114.634
Threshold Setting Gi: 1005951596
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX68039      18 LLSTEKLDRASPDIWPERnYPGIEYVIe--pPRSPEMPALPQSIipQELDKHDYTLVGRYSKLTAQELIAEVKQLQNLAY 95  common water flea
XP_002422723  21 LLSMEELDRTSPELWPEQ-IPGVSEYI----ANTTSFGKGQTWM--KGLDNDDKAFLLYLSKLTPSGLVSEVKKLYDTAY 93  human body louse
XP_008192241  24 LMSMENLDRASPEIWPEK-YPGMTDFVn---SFTPPSAVKLPYS--KELSQDDQNYLHQLAALPTAGLISKVKELHDIAY 97  red flour beetle
XP_011140711  19 LMSLEKLDRASPDLWPEQ-IPGVHEFV----AQNSPQTEPCSWT--ASLTTDDMNHLHQLGNLSMTGLISEVKRLHDLAY 91  Jerdon's jumpin...
OWR50350      28 LLSLEKLDRASPELWPEQ-IPGVSDFV----PLQNPDQSPPSWN--KDLTKEDYNYMQQLGSLTTSSLIMEVKKLHDLAY 100 Danaus plexippu...
Q17CH2        24 LMSLEKLDRGSPEIWPAK-GPSMNEF-----NTPNLNFSPPAWT--KGLTQDDINSMYQLGALSSNGIIAEVKKLYDQAY 95  yellow fever mo...
XP_791156     13 LLSFERLDRASPELWPEQ-IPGVSNFAdi-kSPFNNANSPP-WE--ADLEQNDIDMLNELGSLTTSNLMEKVKGLQNLAY 87  purple sea urchin
XP_027131092  44 LLSFEKLDRASPDLWPEQ-LPGVAEFAa--sCKNPITNSPPKWM--AELESEDIEMLKELGSLTTANLMEKVKGLQNLAY 118 large yellow cr...
EDO49448      15 LLSLETLDRASPDLWPEQ-IPGVSDFAsltaSPYTQSNSPPKWL--NDLEKDDMDMLQEFGSLTTSQLMEKVRGLQNLAF 91  starlet sea ane...
XP_009009148   6 LMSFERMDRTSPDLWPEQ-IPGVSDYSdl-lVSITPEPSPPKWL--DEVEKVDHDMLQEFSSLTTSQLIEKVKDLHQLAF 81  Helobdella robusta
EFX68039      96 QLGLEEAKEMTRGKYLNIL 114 common water flea
XP_002422723  94 QLGCEESKEMTRGKYLKVL 112 human body louse
XP_008192241  98 QLGVEESKEVTRGKYLNVF 116 red flour beetle
XP_011140711  92 QLGLEEAKEMTRGKYLNIF 110 Jerdon's jumping ant
OWR50350     101 QLGLEEAKEMTRGKYLNIF 119 Danaus plexippus plexippus
Q17CH2        96 QLGVQEAKEMTRGKYLNIF 114 yellow fever mosquito
XP_791156     88 QLGLEEAREMTRGKFLDVL 106 purple sea urchin
XP_027131092 119 QLGLEESREMTRGKFLNIL 137 large yellow croaker
EDO49448      92 QLGLDEAREMTRGKFLSIL 110 starlet sea anemone
XP_009009148  82 QLGLDEAHEMVRGKFLNIL 100 Helobdella robusta
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