Conserved Protein Domain Family
Zwilch

?
pfam09817: Zwilch 
RZZ complex, subunit zwilch
The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores.
Statistics
?
PSSM-Id: 401684
View PSSM: pfam09817
Aligned: 15 rows
Threshold Bit Score: 571.716
Threshold Setting Gi: 158293470
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_001954734  27 PPTYLASIAG-------------------VseTGKKVVLVFkedrsg------------------saykiqHITPKKALP 69  Drosophila anan...
XP_003463521  31 PFIYEADVQVqliskgq-----pnpvksiL--GEHDVIFLV------------------------------EKAPLEKEE 73  domestic guinea...
Q8R060        31 PFIYEADVQVqliskgq-----psllktiL--NENDSVFLV------------------------------EKVVLEKEE 73  house mouse
A6QM04        31 PFIYEADIQVqliskgq-----pnplkniL--HENETIFIV------------------------------EKVPLEKEE 73  cattle
XP_007665746  31 PFTYQTDVQVrlvsagq-----qsplesfW--NGKDMVFIV------------------------------EKAPIKEEE 73  platypus
Q95XP9        27 PVLLLDKYRVrvlpltsipfvmnhssvsqLslSSEDVLVVDfpskgtgsgag---------kaekkmifkkKIEPMEDSF 97  Caenorhabditis ...
EFP13192      27 PVLLLNKYRIrllplsslpfvqnysnisqLslNSDDVLVIDspigatekyskks----ienskksmikeedESMEMEE-- 100 Caenorhabditis ...
P0C664        27 PVLLLDKYRVrlvpitelplvsnysntsqLglNSEEVLVIDspiesaekqktssllnrrenkktiksekedESMDMETAE 106 Caenorhabditis ...
EGT35445      15 vksWLNKYRVrlmsvsslpfvsnysnisqLgfNSDDILVVDstvelfqkekrssi---ldnaekrsnikidDSMETEDFE 91  Caenorhabditis ...
Q9VA00        29 PPTYLVSMVG-------------------AaeAGKKIVLVFkedrng-------------------avarlRTTPTRAAP 70  fruit fly
XP_001954734  70 KLEgTSemdltgs---------plkddclVDAIADLSLDLQLEHsNPWKLeeefqrGVPVDQA-RGIISTEPFQQ-SEGT 138 Drosophila anan...
XP_003463521  74 TSH-EE-----------------------LQSEETAISDFSAGE-NVGPL------PLSVGRA-RQFIGLYTMAH-NPNM 120 domestic guinea...
Q8R060        74 TSQvEE-----------------------LQSEETAISDLSAGE-NIRPL------ALPVGRA-RQLIGLYTMAH-NPNM 121 house mouse
A6QM04        74 PSPiEE-----------------------LQSEDTAISDLSTGE-NVGLL------ALPIGRA-RQLIGFYTMAH-NPNM 121 cattle
XP_007665746  74 ANHvED-----------------------IQPEETVISELSVGE-NVGPL------GLSIGRA-RQLMALYTMSQ-NPNM 121 platypus
Q95XP9        98 EDKeNVneggplmtsf---ltleklrkgmVGDVEIIGYECETSFfDANPI------PLSDGVSlQRYIRLNCSEHfSPSI 168 Caenorhabditis ...
EFP13192     101 -DKeNEggengplvtsf-ltleklqkgapLNDIEIVGLDCEVQFfDANPI------PFEDGVSlQRFLRLESSAHfSPAV 172 Caenorhabditis ...
P0C664       107 GDKeNTvsetgggplvtsfltldklekdgVNDVEIVGLDCEIQFfDANPI------PFEDGISlQRFLRLESSKNfSAAV 180 Caenorhabditis ...
EGT35445      92 QDKeNNtvdggplvtsf--ltldklqknaVDDVEIVGLDCEVQFfDVNPI------PFADGISiQRYLRLESSKHfSPAV 163 Caenorhabditis ...
Q9VA00        71 KKEgSAdldltgs---------plkddclVDAIADLSIDLQLDHsNPWKLeeeyqrGIPVDKA-RSIVCSEFLQL-AEGL 139 fruit fly
XP_001954734 139 GSV------------WFLCDGTDLGQTQLLQYEFNKSH-----FSRGILSYHg--VVPAYMVTSQFLVKQHSMVGGGAPM 199 Drosophila anan...
XP_003463521 121 THLkverpvtalpplWVRCDGSDPEATCWLGAELVTAGdsvtgVVLYAVSCK---ADKNYFLSLENLKNVHKTRHHLSTA 197 domestic guinea...
Q8R060       122 THLkikqpvtalpplWVRCDGSDPEGTCWLGAELITTNdiiagVILYVLTCK---ADKNYSEDLENLKTSHKKRHHVSAV 198 house mouse
A6QM04       122 THLkinrpvtalpplWVRCDGSDPEGISWLGAELISTSsnitgIVLYMVTCK---VDKNYSVNLEDLKKSHKKRHHLSTL 198 cattle
XP_007665746 122 THLeisrpvpvlpplWVRCDGSDPEGTCWLGAEPLKTKssitgIMFHIVTSTgpvADKSCLVKLEDLKKRHKKRHHSSTV 201 platypus
Q95XP9       169 STLp----------vWISTTSSKFPSICWLAAGRTNRN----------VQFAa--ATR----VLGHFNNENSERVVKQLN 222 Caenorhabditis ...
EFP13192     173 DKLp----------iWISTISQNIPSVCWIASGRTQKN----------IQFSg--VTR----VIGHF-NEINQKLIKQLN 225 Caenorhabditis ...
P0C664       181 DKLp----------iWISTIGHHFPSVCWLAAGRTNKN----------VQVSg--ATR----ILGYF-NENSQKLVKQLN 233 Caenorhabditis ...
EGT35445     164 DKLp----------vWISTISSHFPSVCWLAAGRTTKN----------IQVSg--VTR----VLGYF-NENSQKIVKQMN 216 Caenorhabditis ...
Q9VA00       140 GSV------------WFLCDGSDLGQTQLLQYEFNPTH-----FSRGILSYQg--VRPAYLVTSQALVRHH----GKTPD 196 fruit fly
XP_001954734 200 ET---SIENSYQVNP---------------QMTIRCSWTTNas------------lPLLVNLHDCEVVLNHTFRAG---- 245 Drosophila anan...
XP_003463521 198 TAkgfAQYELFKSSVlddva-----aqshtAITLDLSWSPV---------------NEMLEVPPLSSAATLNIKVEs--- 254 domestic guinea...
Q8R060       199 TArgfAQYELFKSDDlddtv-----apsqtTVTLDLSWSPV---------------DEMLQTPPLSSTAALNIRVQs--- 255 house mouse
A6QM04       199 TAsgfARYELFKSTAlddtv-----aasqtTITLDISWSPV---------------DEILQTPPLSSTATLNIKVEs--- 255 cattle
XP_007665746 202 ATrgfARYELFRSTAlddti-----salesSITLDVSWSPV---------------DEVLQIPPLTSAATLNIKVEs--- 258 platypus
Q95XP9       223 QAcgtSQLNKYRAVYeeirkiatenrpapgEVTIDVRWSTK---------------STLVLLEHPDNAADCTIKIDlgwg 287 Caenorhabditis ...
EFP13192     226 EAagaAQVNRYRAVYdgirkiatptrespgEVIIDMRWNTK---------------SSLVLLEQPDNAADCIIKIDlgwr 290 Caenorhabditis ...
P0C664       234 EAcgaAQVNRYRAVYdvirkiatptreapgEVIIDMRWNTK---------------SSLVLLEQPDNAADCTIKIDlgwg 298 Caenorhabditis ...
EGT35445     217 EAcgaAQVNRYRAVYegirkiatptrdapgEVIVDMRWNTKvwiklkvvikcfliqSSLVLLEQPDNAADCTIKIDlgwr 296 Caenorhabditis ...
Q9VA00       197 ET---LIENSYQVNP---------------HMRLRCSWTSSaa------------lPLLVNLNDCDVALNHTFRVG---- 242 fruit fly
XP_001954734 246 -ECTPLTQDFMNQLRILVYIREDIVSYHKDIQHGKMRDPTYRCGTGIdMDELrESINKTMTDvSGFI--DPYSNGLAEFD 322 Drosophila anan...
XP_003463521 255 gEPRGCLTHLHRELKFLLVLADGLRTGVTEWLEPLEAKSAVDLVQEF-LNEL-NKLDGFGDS-TKKD--TEAVKHDAAAV 329 domestic guinea...
Q8R060       256 gESRGCLSHLHRELKFLLVLADGIRTGVTEWLEPLETKSALEFVQEF-LNDL-NKLDEFDDS-TKKDkqKEAVNHDAAAV 332 house mouse
A6QM04       256 gEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEF-LNEL-SKLNEFGDS-TKKD--TEIVKHDAAAV 330 cattle
XP_007665746 259 gDPRSLLYHLHRELKFLLVLAGGLKTGITEWPEPLEAKPAVELVQEL-LTDLkNKLDGFVTS-GKKE--AEEVKCDTAAV 334 platypus
Q95XP9       288 dKRFFVDDEIFEQLFFVLNLADVLANPDNEVIFPMAPPAN--------FDDLvQEMDALVEAsSRED------------- 346 Caenorhabditis ...
EFP13192     291 dNRFFIDESIFEQLFFVLNLADVLANPEKEVIFPMEYVK---------FGDLvKEMDDIVEAcSHED------------- 348 Caenorhabditis ...
P0C664       299 dNRFFIDETIFEQLFFVLNLADVLANPEKEVVFRSESDK---------FDDLvQEMKQLVEAcSHED------------- 356 Caenorhabditis ...
EGT35445     297 dKRFFIDEAIFEQLFFVLNLADVLANPEKEVVFPSESAK---------FDDLvQDMNELVDScSQED------------- 354 Caenorhabditis ...
Q9VA00       243 -DCGPLTQDFMNQLRILVYIREDIVSYHTDVKQGVSRDPTYRCGSGIdMDELrESINQTMTDvSGLI--GRYSISNAEFD 319 fruit fly
XP_001954734 323 IEEVvqRAKVRRLTDLTDKLWELLKCC-ASYKDLKVAFSLLFQCAARCNIVN--TPTNKNRLAEIITELSNRRLAMPCLS 399 Drosophila anan...
XP_003463521 330 DRAV--LITVRDDLDFVEQLWCKMSSSvVSYQDLVKCLMLVMQSLQQDDIQPwlHSESNSLLSKLIHQSYHGAMDAVPLS 407 domestic guinea...
Q8R060       333 VRSM--LLTVRGDLDFAEQLWCRMSSSvVSYQDLVKCFTLILQSLQRGDIQPwlHSGSNSLLSKLIHQSYHGAMDSVPLS 410 house mouse
A6QM04       331 DGSIecLLTVRGDLDFAEQLWCKMSSSvISYQDLVKCFSLVIQSLQRGAIQPwlHSGSNSLLSKLIHQSYYGTMDTVSLS 410 cattle
XP_007665746 335 DESIkwLFMERGDLDFAEQLWCKMRKSiASYQDLVKCFTLVIQALKCGDIQPwlHSGSSSLLGKLIQQSYHGTMDVVSLS 414 platypus
Q95XP9       347 --NVfvSNENFRGGDITDKVWNIVRKC-NDVKQVTLLFRNFLQALAYGKIKShaQERNKSHLASLIRISKSSEFKIPVLE 423 Caenorhabditis ...
EFP13192     349 --NVfaSNE--KNEEVTDKVWNIVRKC-GDIKHATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFRMPILE 423 Caenorhabditis ...
P0C664       357 --NVfaSNE--KSEQVTDKVWNIVRKC-SDVKQATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFRMPILE 431 Caenorhabditis ...
EGT35445     355 --NVfvSNE--KSEEVTDKVWNIVRKC-GDVKHATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFRMPILE 429 Caenorhabditis ...
Q9VA00       320 IEDVvqRAKVRQLTDLTDKLWELLKCC-HSYKDLKIAFSMLFQCAARCNIVN--TPTNKNRLAKIITELANRRLAMPCLS 396 fruit fly
XP_001954734 400 GAEPLELLLEIGLEKVLKDYEFIYSESKLCSTHLLRDTNetandegspqnvpqvrkslhnavrgdpaaga-gmrktllhh 478 Drosophila anan...
XP_003463521 408 GTVPLQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFI----------------------------------------- 446 domestic guinea...
Q8R060       411 GTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFI----------------------------------------- 449 house mouse
A6QM04       411 GTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFI----------------------------------------- 449 cattle
XP_007665746 415 GSTPIQMLLEIGLDKIKKDYINCFIGQELASLNHLEYFI----------------------------------------- 453 platypus
Q95XP9       424 RLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILqtcendlp--------------------------------- 470 Caenorhabditis ...
EFP13192     424 RLSTIEMMMEIGVESLRGRIINKFSSTLQFPADELTFILktcenelt--------------------------------- 470 Caenorhabditis ...
P0C664       432 RLSTIEMMMEIGVESLRGRIINKFSDTLQFPSDELTFILktcendls--------------------------------- 478 Caenorhabditis ...
EGT35445     430 RLSTIEMMMEIGVESLRGRIINKFSSTLQFPTDELSFILktcendls--------------------------------- 476 Caenorhabditis ...
Q9VA00       397 GAEPLELLLEIGLEKLYKDYEFIYTESKMCSTNLLKDDSsgasmddgspqnlpqlrkslhnavrgdptpgagmrktllhh 476 fruit fly
XP_001954734 479 nasaktgnakygkvdddsgfkNSHFDEQESLERVSKLFQIHCTL---EHLLMIHINLNLPNVYSDVCSELLKKAPKIVDA 555 Drosophila anan...
XP_003463521 447 ---------------------SPLVEIQEQVHRVQKLHHILELSv--SCMLFLKPQHEFLFSLTQSCIKYYKQNPLDEQH 503 domestic guinea...
Q8R060       450 ---------------------SPSVSTQEQVCRVQKLHHILEILv--ICMLFIKPQHELLFSLTQSCIKYYKQNPLDEQH 506 house mouse
A6QM04       450 ---------------------SPSVDTQEQVHRVQKLHHILEIVv--SCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQH 506 cattle
XP_007665746 454 ---------------------TSAVDIQEQVHRVQKLHHMLEIVi--SCTVLLKLKHEILFPLTQSCIKYYQQNPLNEQH 510 platypus
Q95XP9       471 --------------agngamnSAAISLLPITMALATANRIYELLnekDHVILPDLTRRILQKYTASMIEKSRRGETETEY 536 Caenorhabditis ...
EFP13192     471 --------------tgegalnSSVVSLLPITMALATVNQIFGLLnekDYVLLPELARRVLTKFTSGMIEKAKRGETETDY 536 Caenorhabditis ...
P0C664       479 --------------tlegtlhSSVVSLLPITMAMATIHQIFGFLnvkDLVVLPDLARRVLTKYTTGMVEKAKRGETETDY 544 Caenorhabditis ...
EGT35445     477 --------------tvedalnASVVSLLPIAMALATVSQIFGLLnekDHVILPDLARRVLTKFTSGMVEKAKKGETETEY 542 Caenorhabditis ...
Q9VA00       477 hgavnsrstkyagsdddagfkNSHFDEHESTERISKLFQIHCTL---EHLLMMHIHLNLANVYNDVCSELLKKPPKLVES 553 fruit fly
XP_001954734 556 IDEnvNDVMDIQLSALYvrehlEGKEPYSRHISMRSh---nKFREIKTTFYFNS-------------------------- 606 Drosophila anan...
XP_003463521 504 VFQ--LPVRPACVKSFY-----QSEKPQKWKVEING-----GQKKVKTVWQLSD-------------------------- 545 domestic guinea...
Q8R060       507 IFQ--LPVRPAAVKNLY-----QSEKPQKWRVELSN-----SQKRVKTVWQLSD-------------------------- 548 house mouse
A6QM04       507 IFQ--LPVRPTAVKDLY-----QNEKPQKWRVEINS-----GQKKVKTVWQLSD-------------------------- 548 cattle
XP_007665746 511 LFQ--LPIRPTAIKKFY-----QSESPQTWRVEVSSg---pGQ-EVKTLWQLSD-------------------------- 553 platypus
Q95XP9       537 TFEttLPLLRMYKEGFM-----SKR-PCIWTCENSNtvganVQARVLTSLELQPslehinrlvnd-----srpvwtatee 605 Caenorhabditis ...
EFP13192     537 TFEttLPLLRMSKEKFM-----DKR-PRIWTCENMStvgahCQTRIMTSLELESsmehvsrivnagrpireiveteetqr 610 Caenorhabditis ...
P0C664       545 VFEttLPLLRMNKEAFM-----HKR-PRIWTCENTNtvganVQTRAMTTLELEPslehvcrlvnas---rpvrpidednr 615 Caenorhabditis ...
EGT35445     543 TFEttLPLLRMSKENFM-----DKR-PRIWTCENTNtvganVQTRIMTALELESsvehvsrivnas---rpvremkeene 613 Caenorhabditis ...
Q9VA00       554 IDDqlSDVMDIRLSAHYvrdhlDGKDPYSRHITMRSh---nKFRELKTTFYFNS-------------------------- 604 fruit fly
XP_001954734 607 ENICPPELAKCFQCD-DKEMVKER 629 Drosophila ananassae
XP_003463521 546 SSPVEHLNYPKPDFS-DLTLNGSL 568 domestic guinea pig
Q8R060       549 SSPVDHSSFHRPEFP-ELTLNGSL 571 house mouse
A6QM04       549 SPPIDHLNFHRPDFS-ELTLSGSL 571 cattle
XP_007665746 554 NPPVEHLSFSKQDLS-ESTFNSNI 576 platypus
Q95XP9       606 KPAMIK------DLNaDYTVVHTI 623 Caenorhabditis elegans
EFP13192     611 KPTIE-------ELNaDYTVSHTv 627 Caenorhabditis remanei
P0C664       616 KPTEE-------ERNaDYTVSHTI 632 Caenorhabditis briggsae
EGT35445     614 KPTAE-------ELDaDYTVSHTv 630 Caenorhabditis brenneri
Q9VA00       605 ENICPPNLAQCFQCD-DKEMVKER 627 fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap