Conserved Protein Domain Family
EAF

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pfam09816: EAF 
RNA polymerase II transcription elongation factor
Members of this family act as transcriptional transactivators of ELL and ELL2 elongation activities. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. The N-terminus of approx 120 residues is globular and highly conserved.
Statistics
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PSSM-Id: 401683
View PSSM: pfam09816
Aligned: 98 rows
Threshold Bit Score: 60.7412
Threshold Setting Gi: 146414145
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBQ72053      12 PVAVEPSASalfaaantkaathhnlnsassREALPSYVALNFNFKPDsTHDCRRGALFQpgssRSVNADWQLELEPteTE 91  Sporisorium rei...
OWR52421      13 ELKLGSSFt---------------------NNKTSQYHTIKYDFKPAsVDVNKMATVDV----GT-NNQVTVTVPHldGA 66  Danaus plexippu...
XP_001948068  18 ELKLGSTF----------------------SGKGPGFHTLRYDFKPAsVDINKPASVDI----SSANREVTVSLPNfdGA 71  pea aphid
XP_001847926  13 ELKLGSTFTn--------------------PNPRTVFHTLKYDFKPAsVDTSKPATLEV----GT-NKQVTVTVPHndSS 67  southern house ...
ETN61440      15 ELKLGSTFTn--------------------SAPSSVFHTIKYDFKPAsVDVNKPAVLEV----SA-NKQVTVTVPHldGS 69  Anopheles darlingi
5_pfamImport   1 ELKLGSTFNs--------------------RNTSTAFHTIKYDFKPAsVDFNKVATFNI----EP-NNQVTVTVPNveSS 55 
B4HQT6        22 ELKLGATFNp--------------------KNTSTAFHTIKYDFKPAsVDTSRMASVDV----GS-NNQVTVTVPNseSS 76  Drosophila sech...
XP_011050022  18 ELKLGPSF----------------------TSNSSKFHTLKYDFKPAsVDDSKVARVDV----GS-DNTITVTVPHldGA 70  Panamanian leaf...
EFX69366      13 qLRLGNSFt---------------------NPRGSAFHTFRYDFKPAsVDTSKMATVDI----LP-NNEVNVTVPHcdGA 66  common water flea
EDV27268      13 qfKLGSSFg---------------------SCEEKLFHTIRYDFVPAsIDVHSTGNIKI----GG-NKDCTVTLPHhqNA 66  Trichoplax adha...
CBQ72053      92 geaapgsalessggvakrkpahvFTGpqgavKAYDLVLVWDEEAKVYRLDRIASAFSLKYERSK 155 Sporisorium reilianum SRZ2
OWR52421      67 gvp-----------------qtvFKGsqrpyT-KECVLIIDRDTGEITLEKLSSNIQVKKTRQE 112 Danaus plexippus plexippus
XP_001948068  72 gaa-----------------htvYKGshkdyT-KECVLIIDHTTGEITLEKLTTNVQLKSTRNA 117 pea aphid
XP_001847926  68 gvp-----------------ntvFKGnqrdyTRKECVLIIDRVTGEITLEKLNSNVQVKKTR-- 112 southern house mosquito
ETN61440      70 gvp-----------------ntvFKGnhrdySRKECVLILNRATGEITLEQLNSSIGVKKTRIe 116 Anopheles darlingi
5_pfamImport  56 gvp-----------------ntvYKGvqrkyT-KECLLIIDRDTGVVTLEKLNDNIMMKKTRAA 101
B4HQT6        77 gvp-----------------htvYKGnqreyA-KECLMIYDKETGAITIEKLNHNIQVKKTRNE 122 Drosophila sechellia
XP_011050022  71 gtp-----------------htvFKGsqrpyN-KEYVLIFDKVTGEITLEKLTANIQVKKTRAE 116 Panamanian leafcutter ant
EFX69366      67 gtaq----------------tsvFRGpkkpyA-KECVLIIDHNTGEITLERLSHNIQLKKTRAE 113 common water flea
EDV27268      67 ndpqspq----------qstateFKGsmrpsS-KECILLINKKSKTITLERIGSHMQLKRTRTV 119 Trichoplax adhaerens
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