Conserved Protein Domain Family
Nop25

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pfam09805: Nop25 
Nucleolar protein 12 (25kDa)
Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export.
Statistics
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PSSM-Id: 401675
View PSSM: pfam09805
Aligned: 94 rows
Threshold Bit Score: 45.7245
Threshold Setting Gi: 242247403
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002549851         19 QQKAKKHLVEEVTFDKESRKEYLTGFHKRKLQRQKKAQEYHKEQDRLFKIEERKRIREERKRDA--ELELQKFNETIKNv 96  Candida ...
EGD80697             19 NRKTK----LVVQFDEDDRHDYLTGFSRRKKERQRKAQEAAELQAKESKREEKQHKREALRKRL--SK-LTSIPEILSKp 91  Salpingo...
EDS40677             10 rPGAGAKRKTELVFDPLKRTEFLSGFHKRKLHRKKVAQGQLERKLKEETRRIRTEAK-ENKKKL--YHSYKPIPELTAE- 85  southern...
Q16SG5                9 nkpafVKRKTELVFDPNKRKEFLTGFHKRKEHRKKLAQGDLQRKLKEEVRRIRHEAK-DNVKKL--YHSYKPIPELSAA- 84  yellow f...
1_pfamImport          1 --KTRKKQKVELVFDEQKRKDFLTGFRKRKNERRKKAKEQVEAMIKEERKRIKSELK-AGMKNM--KKSFQPLQELTEE- 74 
WGS:AAPU:GI11943-PA   1 -maARKKKKVEIVFDPQKRKEFLTGFRKRKNERRTRAKAELDRNLKEEHKRIRKEVK-DSFKHL--KKSFEPLRELTEEd 76  Drosophi...
WGS:AAPP:GF10447-PA   2 tKKKAPKKKLEIVFDEKNRREFLTGFRKRKNERRSRAKAQLEKDLKEERKRIRLEVK-DGFKHL--KKSYEPLRELTEEd 78  Drosophi...
Q8SWS7                2 tRKKAPKKKTEVVFDNKKRIEFLSGFRKRKNERRSRAKADLERNLKNERKRIRQEVK-DGFNHL--KKSFEPLRELTEEd 78  fruit fly
Q2LZB2                2 aRKKTPKKKVEVVFDTEKRKEFLTGFRKRKNERRTRAKAELTKNLKDERIRIRQEVK-EGFKHL--KKSYEPLKELTEAd 78  Drosophi...
EFN71242             16 pgqpKRRKKITLVFDEEKRREFLGGFRKRKLERKRKAQEQLQKQLKEERKKIKQEAR-ERYKKFvaHRNVPELEELLSK- 93  Florida ...
XP_002549851         97 knfkgfskdgdnenddededgivgelvSEDDDDDWTekvki-----------sikeDGEWTGFSENp------------- 152 Candida ...
EGD80697             92 e-------------------------wVATNTDTHRfdteekkvsvnvatmeltegPPSIDALTDDdgrpqrkrsktgsd 146 Salpingo...
EDS40677             86 ------------------------------DREEQEydtenvtvkvvelstkelakQNNWIGENHGmvrgdqe------- 128 southern...
Q16SG5               85 ------------------------------DREEDEydtenvtvkvvelsttdlakQNNWIGENSAvvr----------- 123 yellow f...
1_pfamImport         75 -------------------------------DKKQEyeddevevkivelsandfaaQRNMIGANTGqes----------- 112
WGS:AAPU:GI11943-PA  77 ki-----------------------ddSE---QTEAyeddevqvkivelttndlaaQRNMLGANTAees----------- 119 Drosophi...
WGS:AAPP:GF10447-PA  79 ka-----------------------edGQQKAQEESyedeevqvkivelttndlaaQRNMLGANTAeds----------- 124 Drosophi...
Q8SWS7               79 ka-----------------------eeAEQQ-QEETyeddevqvkivelttndlaaKRNMLGANTAees----------- 123 fruit fly
Q2LZB2               79 ka-----------------------geE----KQETyeddevqvkivelstndlaaHGNMIGANTGees----------- 120 Drosophi...
EFN71242             94 ----------------------------------QEydleghtvsilelnvtdlagDR-WIGENKIae------------ 126 Florida ...
XP_002549851        153 --------KDNSDSDDDSDSdsDSEeeekpvkgilhhtevykqepslssisssngngaiidDETTVTIESLD 216 Candida tropical...
EGD80697            147 aaaktsksSAGDNDDDEE----DDTrhl-------------------------------prDDTTTTIEfkk 183 Salpingoeca rosetta
EDS40677            129 -aedesddEGEQQSSEEE----DDEn-----------------------------------EVDTIPGMELd 160 southern house m...
Q16SG5              124 ------deEETDEEQEEDQSssDGE------------------------------------DIDTVPGMELE 153 yellow fever mos...
1_pfamImport        113 ------eeEEEPEEDEEEEV-----------------------------------------DENTIPGMDI- 136
WGS:AAPU:GI11943-PA 120 ------eeEEAPQ-NSED----DDEq-----------------------------------QTNVIPGMDfd 145 Drosophila mojav...
WGS:AAPP:GF10447-PA 125 ------eeEEEKESESEE----DEAs-----------------------------------QANRIPGMDFD 151 Drosophila anana...
Q8SWS7              124 ------epEEQAD-QSEE----DEAd-----------------------------------QANRIPGMDFD 149 fruit fly
Q2LZB2              121 ------eeEEKQS-ESEV----EDTs-----------------------------------RPDRIPGMDYd 146 Drosophila pseud...
EFN71242            127 ------kkEEEQDDQSEH----SNN------------------------------------DNNEIVGMSLk 152 Florida carpente...
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