Conserved Protein Domain Family
NatB_MDM20

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pfam09797: NatB_MDM20 
N-acetyltransferase B complex (NatB) non catalytic subunit
This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyzes the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1. NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions. This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1.
Statistics
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PSSM-Id: 401669
View PSSM: pfam09797
Aligned: 63 rows
Threshold Bit Score: 211.399
Threshold Setting Gi: 149388597
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003654210  298 QTWRKFATAASKTADP---------------DG--SLAEVQNILKRYIEIKDKASeMYKKNLSLALLETTF--RLPatav 358  Thermothielav...
Q17DK2        262 DYYQDYILSTIEMIKCkde----------tpETdhTVDMCHEFIAGIIESQPRKN----RGPYLARLELARlmVKHkfdk 327  yellow fever ...
ETN62358      261 DFYQEYIASTFRLIEAgek----------peGAdySVEMCHEFLCDIIEAQPKKF----RGPYLARLELNRrmIEKryss 326  Anopheles dar...
Q7PYI4        261 DYYQDYINSTFELIRAgek----------pdGAdyTVEMCHEFLCDIIEAQPKKF----RGPYLARLELNRrmVEQryaa 326  African malar...
1_pfamImport    2 NYHLFYLDSVFELGKDkkiahe--------qtdncQYYKAKIFIHSLIKKNETLQ-MKKRGPYLAQLEYYSrlISNslda 72  
XP_003240397  266 IYYTKYYDSLFKIIESkdkylncngntdcvpHFdsSIEEALLFLNELQKLNSEQN-YPQRGVYLARLELYSrlKENayky 344  pea aphid
EFC47691      275 pwwlGLIQSTLLAIQTgqsttsm-ewegktlNChtSIESLHNFIKSHQNS------KDKRGPYLAELELMKvlKQKqmnd 347  Naegleria gru...
XP_004351350  250 SCYMGYFDSLEKIQESgt---------------elDYEKTMEWVKEMQSSLNDKP---IRAPFIAELEVALrtKRSkqe- 310  Cavenderia fa...
Q54C34        252 SCYMGYFDNIWSLND----------------IS--KIDDAKQFIQNIQSQQTSKHl--LRGPLLAEIEIYY--RLLtttt 309  Dictyostelium...
EGC36840      251 SCYMGYFDNLWLLNNNs-------------tPS--NFGEIQNFIKEIQKSSSIKHk--LRGPFIAEIELIY--RKLncsa 311  Dictyostelium...
XP_003654210  359 nptreNERLSA------RVIQIGLFLDQYFERLSAFDDIKGYVAEL----SFE-EVKALMESVVprildedanktrkivl 427  Thermothielav...
Q17DK2        328 eqqfgELT-----------ELLLDYFRMFGDKTCCANDLKLFLEYV----EPA-KRPGFAAQLM---------------- 375  yellow fever ...
ETN62358      327 eqlfgKMT-----------DMLAEYFGLFGDKPCCAHDMKLFIEYV----SPVaERRALAAKLT---------------- 375  Anopheles dar...
Q7PYI4        327 eqlfgKMS-----------DMLAEYFELFADKPCCALDMKLFLEFV----KPAhERRTLATKLM---------------- 375  African malar...
1_pfamImport   73 --qklLGKI---------VDLILRYYEVFGSKECCVHDLRPYLPL-----MSEnECIEFLSSAY---------------- 120 
XP_003240397  345 m--------------gdaiNLLTEYFKIFGQKPCCFYDLRPYMSLL----KEE-LLDEFLRVLD---------------- 389  pea aphid
EFC47691      348 ykfekEAN-----------ELIINYFKTFGSRKICYDDLKVYLELVa-------DLSQLLSKIY---------------- 393  Naegleria gru...
XP_004351350  311 -----------------mlELIKGYFKRFGSKPVYFYDVKKYIQSLinleKDAlTEQEKIDLIE---------------- 357  Cavenderia fa...
Q54C34        310 tangnPAANIDgpvfnkFIELILNYFTKFGTKPVLYSDLKKYLQFIetkkSIE-QRKEIMDRIY---------------- 372  Dictyostelium...
EGC36840      312 t----idkeEFk----qFITLLLDYFKQFGNKPVFYHDVKKYLEFLetrgSKD-DSVKFLESID---------------- 366  Dictyostelium...
XP_003654210  428 ealscklryllstcpqtltpQPSVVEGQP-QDKPFQCRLCSSPASLPceCCL--------------RKLILDAATAYERI 492  Thermothielav...
Q17DK2        376 --------------------QECRINPVTlPSSKEHMQRHICSLQIA--RFCgahaal---seehlSALYTALSLHYEHG 430  yellow fever ...
ETN62358      376 --------------------NGLDITSTTlPGSKEQMQRHICTLQIA--RYSgahsiv---seellHAISTSLSLHYEHG 430  Anopheles dar...
Q7PYI4        376 --------------------NGLGLSSATlPASKEQMQRHICTLQIA--RYSgahaiv---seellHAIYTSLSLHYEHG 430  African malar...
1_pfamImport  121 --------------------KLVSLSESKlPKTKLQMNLMICNMECS--RVIgiremf---dvkskCEFASNAVNYFIHS 175 
XP_003240397  390 --------------------EIVNLKEGEfPKTKPQMECYLSFLQLA--RHVgihdlm---nteekLKLADRLLRCYHRC 444  pea aphid
EFC47691      394 --------------------SSIDSLKVN---QIDKIEYQITFFKIQ--RHTkqnvc-----cateDELITTLVSNYAQA 443  Naegleria gru...
XP_004351350  358 --------------------SLLKLTSED-TAAAVRISQLSNVYRIQ--RLVglqrldslkdekniDKLVNDWLEEYELN 414  Cavenderia fa...
Q54C34        373 -----------------------KLVSLD-KDEANHISQLSNYHKLS--RVLglqlem---sieesIKIIKEILEEYQYN 423  Dictyostelium...
EGC36840      367 -----------------------QLIEKN-NDDTNFISKLSNYYKVQ--RALnlqsdf---thekaQEIIKAILEAYSYN 417  Dictyostelium...
XP_003654210  493 TGE--KELLAAiprlDKDPRLDLALVMGAALLKLSGLRprtsdvtrslwqdVDPGLFLQAVLLLDAQLKETPGDTELRLL 570  Thermothielav...
Q17DK2        431 YNTfgQGLLPT----DMGPSDPYALLAVNIMYDRAWKL-------------QRSEPLVEALCLLNHLLSNSINNFHGKLL 493  yellow fever ...
ETN62358      431 YNAygMGLLTT----DMGPSDSYALLAAHIMYERAWRL-------------QRSQPIVEALTLLHYLLANSPSNFHGKLL 493  Anopheles dar...
Q7PYI4        431 YNAygQGLLVT----DMGPSDAYALLAAQIMYERAYRM-------------QRSEPAIEALCLLNHLLGNSVNNFHGKLL 493  African malar...
1_pfamImport  176 LQFn-TDLQPT----EAKSGDRFALFALHSLFDLWVDT-------------EDGNYLFEAIVICHYALSHSPSNSQFKTL 237 
XP_003240397  445 EIFn-NSKRSS----EIMANDTFVIMMAHLMYDIWVEN-------------NRLTYIREATVVLEYAYALSPSNFHIKLL 506  pea aphid
EFC47691      444 LPLg-KNLLET----DSQYGDEFLLIAAHYLLDRKEYT--------------------SAVILLELALKRSKYNFHFKVL 498  Naegleria gru...
XP_004351350  415 RRAv-GNAQSS----ERYPGDDLVLLAANVLSDRGQ--------------------LLRAAMVLEYGHSVSAKNFQFNLA 469  Cavenderia fa...
Q54C34        424 TKKf-PLAIES----ERYPGDDLILICHFLLMDQYEKT-------------KQVSLLLESAAILEFAHSISTKNYQFNLY 485  Dictyostelium...
EGC36840      418 VNKf-PLPIES----ERYPGDDLVLMCYFFLMDQIEKNp-----------aNKIKYSIDAASILEFGHSKSTKNFQFNLY 481  Dictyostelium...
XP_003654210  571 LVKLYLLL-GCASYAYQLW-IPLDVKRTIQDALSPLFFDR-ISALAPG-LFqgnRGLMEPLRSFY--NQSlreKSPVRIW 644  Thermothielav...
Q17DK2        494 NLQLYHRL-GLVEAAHRAY-ESLDIKHIQLDSLGYLHCSH-LCNGGFPaLA---KQIFDQTLHFFinDT----NSVEFLK 563  yellow fever ...
ETN62358      494 CLQLYHRL-GLTLAAQEAY-DALDIKHIQLDSLGYLHCGQ-LANGGFPsTA---KQVYERTLSFFinDHE---AYAEFPK 564  Anopheles dar...
Q7PYI4        494 ALQLYHRL-GLTQAAQSAY-ETLDIKHIQLDSLGYLHCAQ-LANAGFPaLA---KATYEQTLYFFlnDID---ANSEFPK 564  African malar...
1_pfamImport  238 LLKFYHLF-GACKGAHNAY-LLLDVKHMQLDTLGYLHLFP-LISNGDYtTA---SEVITTTMKFFtnNFK---ESADHIT 308 
XP_003240397  507 LLKFYHML-GASDASNLAY-ISLEIKNTQLDSLGYLHTFQ-MFNEGRFqNA---SKLYATTVRFFshNYR---EVADHLT 577  pea aphid
EFC47691      499 LIRVYATMrSLSSRAFTIFlNELDVKHIQYESISYLIYHD-LMGVGVCdRG---VKVAEKILKFYdsEHRl--YTSQYLA 572  Naegleria gru...
XP_004351350  470 LIVIYGKL-GATSKMVDNI-HKLTIKNIQWDSIGYLVYDQ-LHGHGDYaEL---FNSYDRATKFYteND----STPDFVA 539  Cavenderia fa...
Q54C34        486 LLSLYFEL-GAHQLASNHF-KILNIKNIQYDTLGHLVADQfIREPTCFsNA---INAFEKSAKFYneNE----STADYVA 556  Dictyostelium...
EGC36840      482 LMTLYFEI-GIHTSALSHF-KILNIKNIQWDTLGYLIMDQaVRSPLCFsQS---VNYFEKIFKFYaeND----GTADYVA 552  Dictyostelium...
XP_003654210  645 DAFWAGSYTSILDMTEFDGNLRRSCTLMMTLVEERRAIRCYGgkidce-------------------ieehpLTENIDDD 705  Thermothielav...
Q17DK2        564 TSYNFGSFSKLIEFLDFRDRLSNSLHFTLISVEALLLEMVCFsgtlaqnla-------------ayrlmrikPQEDRIKW 630  yellow fever ...
ETN62358      565 ASYNFGTFSKLVEMIDFRNRLANSHHFALVTVESLLTLVVGFggtlaqcla------------ayrqartskPHEDRIAW 632  Anopheles dar...
Q7PYI4        565 ALYNFGTFSKLVEIVDFRSRLANSYHFMLVTVETLLLMVVSSggtlsqlla-------------ayrqtrrkPAEDRIRW 631  African malar...
1_pfamImport  309 FAYKYEALTKIPEFIWVREKLNNSTHYMKVRFERMLLDIFFAsshantlq---------------likdfeiSPLDKIQW 373 
XP_003240397  578 ISYKFGSFIKIIEFVEFREKLKYSIHNSMCIIENYFISLLDVdnledclei-------------vlkmndvpEIASKSQL 644  pea aphid
EFC47691      573 LPYQKQSWSKIEEMTKFNSRIDNSYSIAKAQIDKLYLKLVFDdv---------------------------rSARDISEQ 625  Naegleria gru...
XP_004351350  540 TCYQQEAYSKIWEIQKFQDRVTNSYQRAANSVEQQLLNLFIVhhrtpqaatlln-------qyrsipadvysTAITEEKS 612  Cavenderia fa...
Q54C34        557 ACYQNGCYSKITEIQKFQVKVANSFQKSVYETERQLFNFMLIrfkklpnanftasqfveicksqisstdpinfdcsnevl 636  Dictyostelium...
EGC36840      553 ACYTNGCYSKILEIQKFQDKVANSYQKQVYSTERQLFNFMMVrlknatnnniaqqqllqnckshiasinndqftitneql 632  Dictyostelium...
XP_003654210  706 TTLVDKTDH 714  Thermothielavioides terrestris NRRL 8126
Q17DK2        631 DEMSDNRDL 639  yellow fever mosquito
ETN62358      633 DKLHDNRDL 641  Anopheles darlingi
Q7PYI4        632 DKLHDNRDL 640  African malaria mosquito
1_pfamImport  374 NILQDNRDF 382 
XP_003240397  645 KKMINNRDY 653  pea aphid
EFC47691      626 LNMTDLDDY 634  Naegleria gruberi
XP_004351350  613 NTLHFNQDl 621  Cavenderia fasciculata
Q54C34        637 nALSFNHDn 645  Dictyostelium discoideum AX4
EGC36840      633 sKLSFNQDr 641  Dictyostelium purpureum
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