Conserved Protein Domain Family
Hyccin

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pfam09790: Hyccin 
Hyccin
Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.
Statistics
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PSSM-Id: 401662
View PSSM: pfam09790
Aligned: 26 rows
Threshold Bit Score: 166.037
Threshold Setting Gi: 548840886
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009014294  60 YESYGESVRNDKELMDELYCLLNHTSFHkydQLLDPVCHQLFN-FYRSSVHSLHCFAIEFIPTIVGSYL--SASMSSSHL 136 Helobdella robusta
5_pfamImport   1 LAAYAKLAHEKDAVLVSFKSAVNSFQNEslvELVQPASHQLFE-FYRSGNNDLKIHAISFFPALVGGYL--LACSSKHEN 77 
4_pfamImport   3 LNKVAPSSLFAANYISTNYTDV---------DLIQPIIGQILAiYYKSGV--LRLYALQFVPGFVSLYL--LALSKKQQK 69 
XP_001897193  36 LTRETCKTQYLINYLSCNYTDV---------DLVQPVVAQLLAcYYRGGI--LRYFVLQCIPSLIHIYL--LALAKRQKK 102 Brugia malayi
XP_016660375  21 wATFAITTSQNKTLIESIYAVLDDIHKYs--KLVDRICGALFN-CYRTEETDLHLFVLLFIPHLTYSYL--NSIAHVDKQ 95  pea aphid
Q9FMI8        94 SDRPALSLLSSRAAYSLISNSLCNPASG---SGSDPLCQWLYE-TYLSSDPPLRLVVLSFFPLLVGMYL--SRIHSSDST 167 thale cress
XP_009112116  71 SDRPALSLLSSRPAYSLISASLRDPSSG---SGSDPLCQWLYE-TYLSSDQPLRLVVLSFLPLLAGTYL--SRIHSSDSS 144 field mustard
XP_004966258  62 SDRPARALLRSPAAYSALSDALRAGG-----GADDPACHWLYD-TLLSADPDLRLAALAFLPLLAALYL--RRLPPELPS 133 foxtail millet
XP_015788203  25 IHAYAIGVFNYPDLINAILNALEDDKQYe--KFLAPICTQLFN-YHRLKDDRLRLFVIAFLPSLIGVHLlySVKPLEVRR 101 two-spotted spi...
XP_009014774  18 llDFAEDIKKDHTLKKEIFFFIENKNKS---EELDPVVHQLFN-FYRLDNDQLKKFSLEFIPAMLLKYY---SAINGQQV 90  Helobdella robusta
XP_009014294 137 H---SG---CLAAFLLGVYNL-----------GNSEMTTINafpiVPSLS-----QPSVYHD-PSsv--slITRLTEAAL 191 Helobdella robusta
5_pfamImport  78 A---SKikvSLGTCLLAIYNLvcee---nekeNSDQNYEIE----MPNLS-----NPSIYHD-PM------AYPFSEYTV 135
4_pfamImport  70 S---VS---LFETFLTAIYNEeivkd-sergtNEKKTEDIR----IPSIR-----HHSVYHD-PAkiqiqtELPITRNAS 132
XP_001897193 103 S---VS---IFETFFLAMFNEeilaggilsesVTKKVEEVR----IPSIR-----FPSVYHD-PKklslasDIALKSGAP 166 Brugia malayi
XP_016660375  96 S---CR---SIEALLIGIYNLeav-----denNTPRFISFR----LPSLA-----QPSIYHE-PSsl---aPTSLTETAI 151 pea aphid
Q9FMI8       168 SlpsLS---GFEAVLLAIYAAevk-----araGKPILVH------IPDLS-----QPSLYHT-PRngv-dkSRD-SNP-- 223 thale cress
XP_009112116 145 SlpsLS---GFEAVLLAIYAAevk-----sraGKGVLVH------IPDLS-----QPSLYHT-PRnggvdrSRDSSNH-- 202 field mustard
XP_004966258 134 S---LS---GFEAVLLAVYSSeak-----nrqGKPVLVQ------VPDLS-----VPSLYHT-PAsspsskSPRRPQPPP 190 foxtail millet
XP_015788203 102 K---YR---CVDTVLLGIYNVeit-----nedGLGSNRTFR----IPTTS-----KPSIYHE-PPtt---sASTFSQPTS 157 two-spotted spi...
XP_009014774  91 V---IS---SLEAFLLGMYNLd---------sTRLKLNCQTdfllQPNSAlifntTSSIYHDiPMgv---tTSMLTRSAL 152 Helobdella robusta
XP_009014294 192 SVR--LNSEHvPVKRPTH-KKY---------DGITPQNRSAILSFVISVYNMNITLMSFR--SRKSLCHLSS-KL----- 251 Helobdella robusta
5_pfamImport 136 NSS--NHGRT-FVKLPPM-KSY---------LNIYPENRSEIMDVIMSCYADYVAIIPTT--SLIQVCDMCL-QI----- 194
4_pfamImport 133 VTP-----VLhTVHFGPF-PSV---------SKMNGENRFTVLNRILFSVNESLFEVASEi-AARYVCLGTL-SV----- 190
XP_001897193 167 AFV----QATkTVRIGPY-KSV---------DRIFPQNRQTVLTRLLKSVNGCLCRLSRDv-ICQGICLSTI-AL----- 225 Brugia malayi
XP_016660375 152 RRL--EQRDThPVRRGPF-NQI---------ERLSASNRMEVLSNLYFIYYKNLNLLPEVynPFDRFYRVTS-KM----- 213 pea aphid
Q9FMI8       224 -------TASvGVLSPQLePQI----------AVKSTKRASIVGVGLQCYFKEISQMPAW--SKLEFCKFSAswa----- 279 thale cress
XP_009112116 203 -------VASvGVLSPQLePQV----------AVKSTKRAGIVGVGMQCYFKEISQMPAW--SKLELCSFAGawa----- 258 field mustard
XP_004966258 191 IPPp-QATPVvGVLSPPLePQA----------AVKSTKRAGIIGVAFEAYYSKISQMPAA--SKVDACNAVAawa----- 252 foxtail millet
XP_015788203 158 TSN--DNSTKaDSSSLPY-INVpvygnykssDYINASNRVSVLTALLHLFHDQMSSLPKQ--SHAALCRMTVsVLeketr 232 two-spotted spi...
XP_009014774 153 DRWhvHNSHQsKIKNVTYlKAT---------DSVTNKNKLTIMIHALQRYNEHISDFSDL--SHLTLCKFCM-------- 213 Helobdella robusta
XP_009014294 252 -----------------------SRTGFEDyveclspianqhcstsgDNGSWQKDPESMHQ------------------- 289 Helobdella robusta
5_pfamImport 195 -----------------------VSQAFPW-----------------HSNFLKVERTNDIR------------------- 215
4_pfamImport 191 -----------------------CRSGFSFpetgfr-----skvlesESPREVIEDFSRKP------------------- 223
XP_001897193 226 -----------------------CQSGFSFretalv-----srvfgsSFHHKEFDDFSKKP------------------- 258 Brugia malayi
XP_016660375 214 -----------------------VTQGYFHkr-------------stSFTNSDISTSTTLP------------------- 238 pea aphid
Q9FMI8       280 --------------------gqdCDCKEKIdededkvl--altngfgD-SSSFNGSSG-RSleieedfdrlairene--- 332 thale cress
XP_009112116 259 --------------------gqdCDCKEKIdgegdkvl--altngfvDSSSSLNGSSEIEAeeveeeeeeqvis------ 310 field mustard
XP_004966258 253 --------------------gqyCKCRFELddk-----------eleEEEGDSLGSVSPMSleaengkeleeelarmhin 301 foxtail millet
XP_015788203 233 ppadwkqilnqhpnsignlhnsaLIPDFPR-------------------------------------------------- 262 two-spotted spi...
XP_009014774 214 --------------------------MFTKtk-------------kdNPNVESQADNNIMP------------------- 235 Helobdella robusta
XP_009014294 290 ----------------KIPFDESLIIEILVGIYYLMFNGLSKLCMQAVDDIHLRASYDLNYPVLLVTNAFLNSLHLNNTS 353 Helobdella robusta
5_pfamImport 216 ----------------RVQITSSVMLSILRSVYFALYNGCRSYAISAIEAAKMRGCYEMCPKVQLFCNAVLNSTLQEDDQ 279
4_pfamImport 224 ----------------RQKVTAEFLNHLLRGCYLALFNGAADLALRAIDSIHMRAQYEMLPETLLVVNSLRNSLLDNMWS 287
XP_001897193 259 ----------------RLRISSQYLLESLNGLYFALFNGTPELAVQAVDAVHQRALYEFYADVILVTNSISETLLESNFH 322 Brugia malayi
XP_016660375 239 ----------------RIPLSPKFLIHLLYCLYISIFNCGKAEAFQALEDIYYRACYSCYCEVILLANAIKNSCQGSFEG 302 pea aphid
Q9FMI8       333 eqlssngggggvgrgvRIPLPWELFQPTLRILGHCLL------------------------------------------- 369 thale cress
XP_009112116 311 ----sngvgvgvgggvRIPLPWELLQPILRILGHCLL------------------------------------------- 343 field mustard
XP_004966258 302 gtssgrncgekddkegRVPLPWELLQPVMRVLGHCLL------------------------------------------- 338 foxtail millet
XP_015788203 263 ----------------KIPVASQLLVRLSSCIYFCIYNGVGDVAIQALDHIHARGLSELYPDVLLMTNAIKHQLSTNPPT 326 two-spotted spi...
XP_009014774 236 ----------------KH-------------------NGQSEAGLMAVSSLYKRAHYDLLPASIMSIGALMSFISNAQND 280 Helobdella robusta
XP_009014294 354 PdlSQEDSKSLSVTASPIQT--------------------------HRHskFP---KDAITNASFRTRKLPD 396 Helobdella robusta
5_pfamImport 280 N--LGNSPLGLPTLLTPILS--------------------------RSSssVS---RHAVTAKSIKDHKWKH 320
4_pfamImport 288 K--------EKRGELMWTRP--------------------------QHKdmIRr--KDLVTNASLKMKRMPE 323
XP_001897193 323 K--------NEELTAQWVRP--------------------------GKLdnHKr--NEVVTNASLRLKKMPE 358 Brugia malayi
XP_016660375 303 ----GQTPNVSSVGTPVSSN--------------------------TCStpVS---KSMITNASFRTKKLPD 341 pea aphid
Q9FMI8       370 --------------------------------------------------------------SPLNTEDVKD 379 thale cress
XP_009112116 344 --------------------------------------------------------------SPLNSEDVKD 353 field mustard
XP_004966258 339 --------------------------------------------------------------APLNPVEVRD 348 foxtail millet
XP_015788203 327 Q--SGDCPAEIPVTFTPTST--------------------------VTSttSSssnKTAITNASFKTRKLPE 370 two-spotted spider mite
XP_009014774 281 EddDNNGDNAATTTTTTTTSqlkkllprhlqqhdaqqkflsqqqsqQQQqqLT---REAITNATFRTQTMPE 349 Helobdella robusta
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