Conserved Protein Domain Family
Tmemb_55A

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pfam09788: Tmemb_55A 
Transmembrane protein 55A
Members of this family catalyze the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
Statistics
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PSSM-Id: 401660
View PSSM: pfam09788
Aligned: 17 rows
Threshold Bit Score: 323.209
Threshold Setting Gi: 942200874
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OCA50761      48 DGERSPLLSDlgdgggigaamgpgapspgTVLPT---APPYGGpgp----tsnN----KPqgf-pefPAA----HG---- 107 tropical clawed...
4_pfamImport   1 DGERSPLLPEqrd-------------ganGVSPG---GGSLGYfkypagvirpS----SPlhvlfppPRSfpvcHT---- 56 
XP_006013160   6 VDERSPLLSApn---------------sgNVTPT---APTYIS----------E----NS-------PRA---------- 36  coelacanth
XP_009861115   5 nDETESLL-------------------------StqnNVSNGG----------AstsvNP-------PSYakaaGD---- 38  vase tunicate
XP_015781621   7 tdENQPLL-----------------------GAVggvETTNGS----------NgdrwKP-------PKSevyvRPa--- 43  two-spotted spi...
Q2LZQ8         3 DPERQSLInk-----------------deSIMYTssaAVDEGA----------E----NP-------GSStaavPNedgn 44  Drosophila pseu...
Q16QP8         4 ESEKQPLL----------------------KQSSqsgQPDSGS------------------------EQPsqaiVTa--- 34  yellow fever mo...
XP_011145409   6 EGERQPLLkn------------------eNVTYSshgSDAFEE------------------------SQStvntVS---- 39  Jerdon's jumpin...
2_pfamImport   1 --EKKPLLpy-----------------dsKSNYSansATATSN------------------------GQTtv-------- 29 
CAG02185       3 DPERSPLLSEhhd-------------gtnGFSPG---GSYYGYp---------P----KPqtl-apfPAS---------- 42  spotted green p...
OCA50761     108 -------SVIAGEDPPPYS---------PLTSPESG-SAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPQGK 170 tropical clawed...
4_pfamImport  57 -------PVAAGEPPPPYS---------PQGSPDSGsSAPVISCRVCQSAIPVEGKAHQHVVKCDICNEATPIKNAPVGK 120
XP_006013160  37 ------------ELPPPYT---------AIASPDAG-GVPVINCRVCQSLINLDGKLHQHVVKCTICNEATPIKNPPAGK 94  coelacanth
XP_009861115  39 ----------LTEQPPPYSftapnivsvPSDETSPVmQMAVINCRVCQTLLHVEGKLHLHVIKCYACGEATPIRPPPAQK 108 vase tunicate
XP_015781621  44 ------dSSYTSDGPPAYE---------PTLSMSGG--RLAIACKVCGAMIDVTEKREQHVVKCEQCNEATPIKPAPAGK 106 two-spotted spi...
Q2LZQ8        45 gaptavpCIGPDELPPPYQ---------QS-SNTGG--VPMVTCRVCQHMIDITTKREQHVVKCTHCNEATPIRNAPPGK 112 Drosophila pseu...
Q16QP8        35 ------sSIGPDEVPPPYQ------------QEQQS--SVIVTCRVCQALIDISWKKEQHVVKCSQCHEATPIRNAPPGK 94  yellow fever mo...
XP_011145409  40 -------TIGPDELPPPYQ------------SATQG-GMPMVTCRVCQAMIDISGKRDQHVVKCSQCNEATPIRNAPPGK 99  Jerdon's jumpin...
2_pfamImport  30 ------sPIGPDELPPSYQ------------AALHG-NAPMVTCRVCQAMIDVSGKRDQHVVKCSNCNEATPIRNPPPGK 90 
CAG02185      43 --------VVLAEPPPPYS---------PQGSPDSG-SPPVVNCRVCQSAISVEGKMHQHVVKCGICSEATPIKNPPVGK 104 spotted green p...
OCA50761     171 KYVRCPCNCLLICKVTSQRIACpRPYCKRIINL-----------------------------GPV----HAGPLSPEP-- 215 tropical clawed...
4_pfamImport 121 KYVRCPCNCLLICKVTSQRIACpRPYCKRVINL-----------------------------GPV----HIGRESPEPqh 167
XP_006013160  95 KYVRCPCNCLLICKDTSRRIGCpRPNCRRIINL-----------------------------GPVllipEEQPAQPALpv 145 coelacanth
XP_009861115 109 KYVRCPCNCLLICKISSQRIVCpRSDCKRVISL-----------------------------KPV----VPNPVSDEV-- 153 vase tunicate
XP_015781621 107 KYVRCPCNCLLVCKAPAQRIACpRRNCLRIINLnlenrsnagnqipsalneggermdnvtssGPL--------------- 171 two-spotted spi...
Q2LZQ8       113 KYVRCPCNCLLICKSSSQRIACpRPNCKRIINL-----------------------------APS-------PVTPPVpt 156 Drosophila pseu...
Q16QP8        95 KYVRCPCNCLLICKSSSQRVACpRPNCKRIINL-----------------------------APS-------PVTPPLls 138 yellow fever mo...
XP_011145409 100 KYVRCPCNCLLICKSSSQRIACpRPNCKRIINL-----------------------------APS-------PITPPVls 143 Jerdon's jumpin...
2_pfamImport  91 KYVRCPCNCLLICKSSSQRIACpRPNCKRIINL-----------------------------SPS-------PVTPPLps 134
CAG02185     105 KYVRCPCNCLLICKVTSQRIACaRPYCKRIINL-----------------------------GPV----HISRESSEPqh 151 spotted green p...
OCA50761     216 QPVGVRVICGHCKNNFLWTEFTdRALARCPHCRKVSSIGMRYPRKRCFCCFLLGVLLALAAAGLV--------------- 280 tropical clawed...
4_pfamImport 168 QPVGVRIICGHCANTFLWTEFSdRTLARCPHCRKVSSIGRRYPRRRSLLCFLLFVVLATSTAGL---------------- 231
XP_006013160 146 QPEGTRVVCGHCGNTFLWMELRfNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICVFIGVGLT--------------- 210 coelacanth
XP_009861115 154 SNLSRRVICAHCLYPFYWTRPS-STRAKCPQCKKTSSVGNKYRRQRIQCFGILSLISLCIAIIVN--------------- 217 vase tunicate
XP_015781621 172 -PEMCRVTCGHCYESFLFNTLS-NSLARCPHCRKLSSVGPEFARFKGLVYLVISIIFFAIALGVT--------------- 234 two-spotted spi...
Q2LZQ8       157 MPGMCRVICGHCSDTFLFNTYH-NALARCPHCRKVSSVGSRFANSRGVMFAIVALLFLVAGIAVT--------------- 220 Drosophila pseu...
Q16QP8       139 MPGMCRVTCGHCHDTFLFDTLK-NNLARCPHCRKVSSVGADFCRKRRNLLFLGGLIFLAIGMGVT--------------- 202 yellow fever mo...
XP_011145409 144 MPGMCRVGCAHCHDTFLFNTLN-NALARCPHCRKISSVGPDFARGRGIVFIIVGIITLIIAIAVT--------------- 207 Jerdon's jumpin...
2_pfamImport 135 MPGMCKVTCVHCRDTFLFNTLR-NALARCPHCRKVSSVGPQFAKNRGKIFLVIALILFAIGVSIT--------------- 198
CAG02185     152 QPVGIRVLCGHCSNVFLWKEISdRTLARCPHCRKVSSIGRGYPRKRSLLCFLLFVVLVASTAGLMvsvcvylslctfkgr 231 spotted green p...
OCA50761     281 ------------GGTWTLAYKYGGIYASWAIVLLLALACLGRGIYWACMRVS 320 tropical clawed frog
4_pfamImport 232 ------------VGTWTPARHSKGIYVSWVLLILLALFTMARSIYWRCLKIS 271
XP_006013160 211 ------------VGTQDFARRYHATYVSWAFAYLLGLICLVRACYWGAIKVS 250 coelacanth
XP_009861115 218 ------------IVTYHQQFGVVLKYGLWGLLYFISFVEVIITIYFLRMRVS 257 vase tunicate
XP_015781621 235 ------------LGTLKYFSDFKSLIVLYIILFIADVAIIFRSLFYLTMKVS 274 two-spotted spider mite
Q2LZQ8       221 ------------IGTISYASAHGGMYILYVALFVIAVSMLARSAYYFRLKVS 260 Drosophila pseudoobscura
Q16QP8       203 ------------YGTLAYAKDHSGMYIAYISLFLVALLLFGKTIYYCTLKVS 242 yellow fever mosquito
XP_011145409 208 ------------LGTYRYVKTNGGIYVAYVGAFLLALLCLGRSIYYCTMKIS 247 Jerdon's jumping ant
2_pfamImport 199 ------------LGTYKYATINGGYIFAYIGAFLVGVIMLTRSIYYYTMKVS 238
CAG02185     232 milqishdfyhqVGTWKPAQNSKGIYVSWVLLILLTLLTVARTIYWICLKIS 283 spotted green pufferfish
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