Conserved Protein Domain Family
FimP

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pfam09766: FimP 
Fms-interacting protein
This entry carries part of the crucial 144 N-terminal residues of the FmiP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C-terminus contains a putative nuclear localization sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.
Statistics
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PSSM-Id: 401641
View PSSM: pfam09766
Aligned: 57 rows
Threshold Bit Score: 190.594
Threshold Setting Gi: 74859551
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEY60744      59 RDTFLEADARRTRVQEQKDVAEAHQLQLQNLLYEKDHLLREIRRCRGFS---TKEMDk--------IEFADgPLPIKVd- 126 Phytophthora in...
Q010M5        91 CAALSGLEHLRDKTGERNVEVNRARTRAGTIAYETATLERELR---DFEredGASGSvkgvdlmdrGEYEA-DARARGld 166 Ostreococcus tauri
XP_001420073 101 RRALMGLEYLKAGTRRRDKETDPARVRAATVAYETAWRESALKRHADAEg-sGGGVSaggielmelKEYEA-DAKRRGlp 178 Ostreococcus lu...
XP_001744967  60 RQAGKQLVTGAEANAQMKADIDSVHLRLQNVLYEKLHLLKETAACNQFR---AKTDDmal---isaAELSP-ELQTD--- 129 Monosiga brevic...
EGC30418      98 RDTYLDSEYNKAKTNEEKVKLEALNLTYQNILYEKYHLEKEINSLKDFN---IDQFKpel----lpIETYN-SKVQDIsy 169 Dictyostelium p...
Q1ZXD7       134 HKTHIDSETKKTKKNEEKEKFEKLNLVYQNYLYEKNHLEKEINSYKDFK---IDDQKpkl---lslEDFEN-----KIkd 202 Dictyostelium d...
XP_004351476  95 RSIVFDMETWKTQVDKDKQKLDHLNLFYENFIYEKNHLLKEIHSTSDFD---ISAFEpil----vdEMYYNdKKQQDIta 167 Cavenderia fasc...
EFA84452      88 RFYQFQAENSKLDVEKERQKFDSLNLLYQNYLYEKNHLLKEIHSLSEFN---ISQYEpnl----veQLYYEsESIDIPtm 160 Heterostelium a...
2_pfamImport   7 RLCYYATAQIRKEVAERMEVVDTKLLQLQNVTSEVQHIQKEIDRCLDFS---AGDEDlel---isvEEFYQ-QAPESLsk 79 
XP_002648416 100 RLCHYATAQMRKEVAERMDLVDAKLLQLQNVTSEVQHIQKEIDRCLDFS---AGDEElel---ipvEEFYA-EAPETIsk 172 Caenorhabditis ...
EEY60744     127 ---------------pDVHRQHLDQLTQELHARKSLQTELKELKLKITKVEDATETKQAFL-NALPDHLAGIEAATTGLQ 190 Phytophthora in...
Q010M5       167 t------------eaaDEYDEMKKRLAHELIVRKELVERQKALTLELAEVKAAIEERKKTL-SGDPGAIKAMKRHAEELR 233 Ostreococcus tauri
XP_001420073 179 tk-----------kprDEYELMTRRLAHELIVRREMVEEQNALKAELAALQQQVAEKKKLLgGSLEATMTNVRKSAEPLR 247 Ostreococcus lu...
XP_001744967 130 ----------------DPHQQMLNRIEAERRERERLVDQLEELSQRQSAMKALNKQKASKL-KQLPRAINRLAEVASDVS 192 Monosiga brevic...
EGC30418     170 nttfksepidtndielNEHNKLVNRLNFEIYERNRMIEQFNKIQRDKKLLLGLNNTKQEFL-SSLSKNLSVISTKIAPVQ 248 Dictyostelium p...
Q1ZXD7       203 ctsiklesvdtgneelNQHNLLLNRLNFELYERNRTIEQLNKIQRDKRLHLGLNTTKQEFL-SSLLTNVTALASNISNIQ 281 Dictyostelium d...
XP_004351476 168 eqqssss-speldeetQKHNQKMARLQFELDERIKKLDQLNKLNQKKKLHTEINISKQNFL-STLPKSLSSLSNKLs--- 242 Cavenderia fasc...
EFA84452     161 pidi-------dteeeIKHSKIIHRLNFELKERIRVLKQLTQLQEQKKNEIHLNQSKQNYI-SSLPKMVSDLSKKLLTIQ 232 Heterostelium a...
2_pfamImport  80 pe----------etmgDEHEQYVARLKFEMDQRQDLLSTLQELEGRRNVLQSDIRGKEVRL-QGLKPKLEDLAKEAEPAF 148
XP_002648416 173 ae----------etmgNEHEQYLARLKYEDNQRRDLLSTLNELEGRRNVLQSDIRGKEVRI-QGLKPKLDDLAKMVEPVF 241 Caenorhabditis ...
EEY60744     191 KYM---------GE----PVTaQRNRHHAAGTELSTPLYALYCELEAYQTASGdaGKrLQ-----LEIVDSIgvkhtgay 252 Phytophthora in...
Q010M5       234 RKF---------DL----PYT-TTETLDKQVAVLPGPLYILYAQLKHAQQM----GEdIR-----VQILGRE-------- 282 Ostreococcus tauri
XP_001420073 248 RMF---------DL----AYA-STEDLDARIGLLPVPLHVLYAQLKHLQQN----EEeIK-----VELVGRI-------- 296 Ostreococcus lu...
XP_001744967 193 NVF---------SRhqdnALP--AGSNDPRAAALPLPLFVFYETTTAFIQLETepSG-LH-----VSIEGEA-------- 247 Monosiga brevic...
EGC30418     249 NSLiksitsinnPPlmskRTAsFNSTFEQTVFNLPKPLYVLYYTVNSFLQSNKttNN-NGakspsLRIKGDM-------- 319 Dictyostelium p...
Q1ZXD7       282 PS--------------------STSNYEQSIFNLPKPLYVLYYSVNSYLQSNT--KStMNsdnllLKIKGDM-------- 331 Dictyostelium d...
XP_004351476 243 ------------------QIGsSTSNYNPTAFYLSKPLYYMYSSILSYQSSCK--KPdFN-----IKIIGDI-------- 289 Cavenderia fasc...
EFA84452     233 PNL--------------------NSSYNQNIFHLPKPLYIIYSSVTSYQSSTKk-SN-LT-----LKIVGDI-------- 277 Heterostelium a...
2_pfamImport 149 EMV---------GAkf-kDLS-MEEDQKQLALTLPSPLIVAHIHAMAYKEIHDd-KH-FD-----FRIVGSN-------- 202
XP_002648416 242 DTV---------GAkf-kDLT-IDAEQRKMSLSLPAPLAVAHIHATAYKEIHDd-KM-FE-----FSITGNN-------- 295 Caenorhabditis ...
EEY60744     253 rkrgfptalerqEHASTKRlkapsrspsASLNGATPPhsrapsrspsvkRVADSSSQEPESgeivaahtaekLLQLRPHE 332 Phytophthora in...
Q010M5       283 ------------ADAEAYEe----------------------------aMENPTATDDGNVr-----------DERDGHK 311 Ostreococcus tauri
XP_001420073 297 ------------DDAQNFK---------------------------------QKKASEEEGelvd---egaeNNRRSKKR 328 Ostreococcus lu...
XP_001744967 248 ------------SAVPNFD---------EAVAGLISVktsvqsghqrddEEDNSSDSPAAVq------------------ 288 Monosiga brevic...
EGC30418     320 ------------EKAIKFN---------KEYV--------------------EKQTPDNETn------------------ 340 Dictyostelium p...
Q1ZXD7       332 ------------DKATIFN---------SDFMIYSQQtqhqhhqqqqqqQQQQQQQQQQQQqqq---------------- 374 Dictyostelium d...
XP_004351476 290 ------------DKASTFNqqq-------------------------qqQQQQQQQQQQQQqqq---------------- 316 Cavenderia fasc...
EFA84452     278 ------------EKAIDFN---------TKSNVAVVDn-----------DVDDGGVVDGEIn------------------ 307 Heterostelium a...
2_pfamImport 203 ------------DNSQNVK---------E----------------------------ETDS----------------KRR 217
XP_002648416 296 ------------ETTKPTK---------E----------------------------DGET----------------KRR 310 Caenorhabditis ...
EEY60744     333 EEtkeetkdqdenSEAATSQKLWNP-----------HARALQLTISVtvpmdtdkngtttktvsgsFTVMFQYFPVAKMV 401 Phytophthora in...
Q010M5       312 RQrggrggrgrggRGMKLSSSTYAE-----------HPLRIELDGVGg------------------RKVIFNYLTKLHMV 362 Ostreococcus tauri
XP_001420073 329 KArg-------grQAASASSSLYEE-----------HPLRVEVGFGAt-------------------KVFFTYLTKLHVV 371 Ostreococcus lu...
XP_001744967 289 ---------------------ANTP-----------HPLTLKLSVKTak---------------vqVAWTLRWYPVVDMV 321 Monosiga brevic...
EGC30418     341 ------------eEQPNEEDQYYYI-----------HPLSVLLDYTIld---------------tkTTLQFRWNWSKNVV 382 Dictyostelium p...
Q1ZXD7       375 -----------qqQQQQQQQQSQEEitlrnnnnsdyHPLSVILDYLIfd---------------tkVSLEFTWDWFRNIV 428 Dictyostelium d...
XP_004351476 317 -----------qqQQQQIDQQPLTV-----------HPLSLEFEYRIsk---------------elVSIQFYFLADENII 359 Cavenderia fasc...
EFA84452     308 ------------------NDQLIAVaqy------iiHPLSLIIEFQCen---------------qtTQLQFHSVVNLNLV 348 Heterostelium a...
2_pfamImport 218 RKedet----tqeKVNEMAGRIFDV-----------HPMSLEFDIDCanme------------dfkVTMTIQYLTELKVT 270
XP_002648416 311 RKedet----iqeKINEMASKILDV-----------HPMSLNLDIECsnd--------------lkITMSIQYLTELKLT 361 Caenorhabditis ...
EEY60744     402 TAEVVKTAPA-----GFYPGSQRcmLTNLFP-GDDG-LTV----------------------PQVAVNYTFQ-------- 444 Phytophthora in...
Q010M5       363 IARANPGkd--------------daLKDLFP-GDDG-SAT----------------------PNHAIEIVESdftfdes- 403 Ostreococcus tauri
XP_001420073 372 VVSSKPE------------DEKF--LGELFP-DDDG-SEM----------------------PNHAVAVVAPnftfdas- 412 Ostreococcus lu...
XP_001744967 322 TVEQD--PAP-----GLLEDA----LSHLYV-NDTG-TEI------------------------VNTRIALQeavarsa- 363 Monosiga brevic...
EGC30418     383 -------LCK-----TLGHSDYY--LFNIFP-NDNG-FSNytngidipplsissqfaspftsPTPLSPKPINnnstskrn 446 Dictyostelium p...
Q1ZXD7       429 -------LCK-----PIDHSDFY--LYNIFP-NDTGlLASftgdvei--------ppisitsPTPLSPKPINnqqpsqqq 485 Dictyostelium d...
XP_004351476 360 -------VCS-----INTDNQSY--LSNLFP-NDIGddfiq-----------------sfttTNTNGPKQSN-------- 399 Cavenderia fasc...
EFA84452     349 S------LVT-----TDAQDDCF--LSNLYCgNNVGcgg---------------------veLHPSIPIPLNsnnnnnss 394 Heterostelium a...
2_pfamImport 271 TAKWHIHadsklkksplFSTDSL--MSDLFP-GDSG-DQC----------------------PNTVGAIKMEhlkln--- 321
XP_002648416 362 TAKWSIHqdskakksilFNADSL--MSDLFE-DDSG-DKC----------------------PSKVGDLKSEhlkln--- 412 Caenorhabditis ...
EEY60744     445 ------------EDsdeRTevefpasaacRPYYWTQWICGLNP 475 Phytophthora infestans T30-4
Q010M5       404 -----------------------ctgyggKPYKWAQDLAGMSF 423 Ostreococcus tauri
XP_001420073 413 -----------------------capsnaKPYKWAQNLAGLSF 432 Ostreococcus lucimarinus CCE9901
XP_001744967 364 ------tvddllSE---RQ----------RAYRWLQICSGLve 387 Monosiga brevicollis MX1
EGC30418     447 nf-lapsplpplSPpssLG----------KPYKWVQVLCGLLP 478 Dictyostelium purpureum
Q1ZXD7       486 shqnninvniidSYnsgFG----------RPYKWTQVLCGLLP 518 Dictyostelium discoideum AX4
XP_004351476 400 ------------STlniVG----------KVFRWAQLLGGLmv 420 Cavenderia fasciculata
EFA84452     395 snsnssnsnsniNNqsrSG----------KFYDWVQMLSGLvh 427 Heterostelium album PN500
2_pfamImport 322 -------fdtnaKQ---LG----------KPYRFLQDLS---- 340
XP_002648416 413 -------fnsnaKT---IG----------KPYKFIQELSGTge 435 Caenorhabditis briggsae
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