6SRI,3K1L


Conserved Protein Domain Family
WD-3

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pfam09765: WD-3 
WD-repeat region
This entry is of a region of approximately 100 residues containing three WD repeats and six cysteine residues possibly as three cystine-bridges. These regions are contained within the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2. The WD repeats are required for interaction with other subunits of the FA complex.
Statistics
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PSSM-Id: 401640
View PSSM: pfam09765
Aligned: 47 rows
Threshold Bit Score: 44.5974
Threshold Setting Gi: 568249250
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SRI_Q                6 SLLRQCPL--L--LPQNRE--GTAYEGFVSAQG-RDFHIRILLPTdS-QLKNARIECSWHLKKILHGYQhi-lkQRLHSC 76 
XP_001953619         14 LLADKYFGlvA--DVKEDG--SYIIRGTFMLED-NWLRLKLYLPH-YpALNGFELYVLEKFEYKLYTAEn----mTVQDD 83  Drosophi...
XP_017057622         11 FLAENYPGlfA--ELRPNG--SCLIQGNICKEG-TCRPLKLYLPH-YpVLNDFQLFLLEKMEYKKYTSEn----lKVQDE 80  Drosophi...
NP_001287266         10 LLCQKYPGlaA--ELQPSG--ACIIRGVLGSED-TWRRLKLYLPH-HpALHGFQLYVQESLEYKLYTSAn----lKLQDD 79  fruit fly
WGS:AAQB:GK11033-PA  11 ILANKYPGlvV--ECGGTNpkSLLIHGVMSSSEgRWLRLKLLVPN-YpGLKKFQLYVQHQMEYKCYTSQn----lPIQDN 83  Drosophi...
Q17FW9               10 NFLQKYPF--L--VE------TSTKNRFIGCYN-SKFTVHLALPAf--------PETDRSSVGVFHGIEpl-dvQSMLKT 69  yellow f...
9_pfamImport          3 DFLQKFPF--F--VQLQ----TCHFVGLYK----KVYKIRLHFPDy--------PTTNNRSVAVFRGNVpitliPELATL 62 
7_pfamImport          3 EFLQSFPF--L--VQLE----PYHFVGLYQ----KVYKIKLYFPKy--------PTTDSHRVTVFHGNHpialpSEQSSI 62 
ETN59061             14 EFLREFPF--L--VELD----HFHFIGLYK----RIYKLDMRFPRf--------PSAEQHYLAIHRGHIrvpvtVERLSF 73  Anophele...
3K1L_A               10 LLCQKYPG--LaaELQPSG--ACIIRGVLGSED-TWRRLKLYLPHhP-ALHGFQLYVQESLEYKLYTSAn----lKLQDD 79 
6SRI_Q               77 PDLVSFVVELKT--ILEI 92 
XP_001953619         84 WQLEDFIDKLPQ--LLPP 99  Drosophila ananassae
XP_017057622         81 WMLKDLLANLPKapLCPK 98  Drosophila ficusphila
NP_001287266         80 WLLEDFLDHLPK--ILPA 95  fruit fly
WGS:AAQB:GK11033-PA  84 WNLEDLLANLWE--LMPS 99  Drosophila willistoni
Q17FW9               70 ADAFEFMDSLLQ--FLDS 85  yellow fever mosquito
9_pfamImport         63 VEVDEFVHKLLA--WLDS 78 
7_pfamImport         63 VQVDKYVHNLLA--TLDS 78 
ETN59061             74 NDAKSFVKSILE--ALNG 89  Anopheles darlingi
3K1L_A               80 WLLEDFLDHLPK--ILPA 95 
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