Conserved Protein Domain Family
Sec3_C

?
pfam09763: Sec3_C 
Exocyst complex component Sec3
This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.
Statistics
?
PSSM-Id: 401638
View PSSM: pfam09763
Aligned: 20 rows
Threshold Bit Score: 520.736
Threshold Setting Gi: 74854025
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q57ZX4        198 DD--IRATEKLLSTHQKKAELLSVNDLVISACaWEEVREHI-SSIMEDVGEMEARIAQYSKCILSQKEQLQRIEHQHNTL 274  Trypanosoma b...
XP_001487248  595 TSdnGDILIKKLSHELSALKYNNVKQLVTLDFgHNSISKDM-TDSLNELSNLSTVFKRAELGFKFLSHEINSIENDSKGL 673  Meyerozyma gu...
EAZ63010      638 ITddSDSLIKKLTRELNNVKQQNVRELIGLNFgSSNVSKDV-GTSINEVENLSHIFKKMEIDFKFLSSEVDTIENNSQGL 716  Scheffersomyc...
Q6FRC5        652 DD--ADTLLEKVNTNLSKTEYMFNTSLLTLSKlSNNLQPYE-TNVNKACDNINPTFSLFLMEMSNCSEDIDYVESQNNGL 728  [Candida] gla...
EDO14650      776 ED--ADKLVERLDYKLAETEYDFNNDLLLLENlQTTLSGYE-QNVSKECEKINPTFSLFLMEMNNLLDDIEYVERQNNGL 852  Vanderwaltozy...
Q6CQX3        540 DD--SSSLLEKLHSRLADVDYQLNKNLLFLPKsLGELNPYK-DLVFKECDKLDPTLSLFTMELSSVSNDIEFVESQQNGL 616  Kluyveromyces...
Q54NV1        107 FEkdVDILTERLGKTLSTLETEMIVGVLDSGVgVNEVISQLgDKDGTHLTGVTAWIEYYNKQLQDMKKYIEHIEGKNNKM 186  Dictyostelium...
XP_001636490  163 AIsnIETFTDQLSKDLSVLDGANIYSIMASEDqVTSLMDLL-EAALVELDKLDTRLTHYDDKLRTVREHMEQMEDKDRHM 241  starlet sea a...
Q9VVG4        198 AIkdAEQFIEQLSRELHDLDGANMQSVLASEQkVLKMMEHI-DNAISEADKFENRLDSYEDILGHVKETMEKIGGKNAMI 276  fruit fly
XP_005160613  189 sN--AEAFAEKLSRELQVLDGANIQSIMASEKqVNTLMQLL-DQALAEVDTIEGKLLSYEEMLQSVKEQMDQISQSNRLI 265  zebrafish
Q57ZX4        275 QRKQQNLHKLQEQLQVVRGQLNLPPQVTALLQRvGEARSEDLEEFLsnESNVRRLSDAVGLITSLLQn--tKLESDY-PI 351  Trypanosoma b...
XP_001487248  674 QVKSINKKLLYNDLKGVLSKISINADDLRDIESfTQFDRLNLLEPL--EEKLLDLHYALGAIRNDFEe--dSKPTGLgTM 749  Meyerozyma gu...
EAZ63010      717 QVKSINRKLLYNDLRGILSKVSVNSDDLRIIEGfTEFDRLNKLENL--ELALLDLFNALSTIKHDPT----EDDFYLsSM 790  Scheffersomyc...
Q6FRC5        729 QIESANKKQLWSTLDNLLKIVSLDEETLNKLLN-CPIREKN-LPWI--EEQLDAMCKAYNAIEGAKN----NDESNLrDL 800  [Candida] gla...
EDO14650      853 QVESANKKLLWSLLTDLLNTVSLDENALNELLS-STISERS-LPRI--EIQLEGLFNAIKAIKGETK----TETGDLgKI 924  Vanderwaltozy...
Q6CQX3        617 QVRVANRKLLWKELNEILNSVSIDEKSLHELLR-LPMSKTS-IERM--EVLLVELYAALKAIDGSKDqfvqDSEDDLsDM 692  Kluyveromyces...
Q54NV1        187 EIVSRNQKLLYSELNNLIGLMTLSDNTISTLTA-PQFNDTKGLKMA--IEAAEDLKRALTT----------KLKSGMdNM 253  Dictyostelium...
XP_001636490  242 ETESTNRQKLLKQVEFLVNTLDIPERHIIALQE-GDLSKGLAVKEC--TNAAMAVLEALQA----------DLPKGLqEM 308  starlet sea a...
Q9VVG4        277 EIANNNNIKLMKELNKVISQLDLPHSQQQALDE-PDLKTANGRKAA--IAAAQCLQQAMNS----------DIDPALlRL 343  fruit fly
XP_005160613  266 QISNTNNGKLLDEIQFLVNYMDLSKGHIKALQE-GDLSSPKGIEAC--INASEALSQCMNV----------ALKPGHdKL 332  zebrafish
Q57ZX4        352 ALVAARRAFFAEQRRAIAHRTKTYILDAISRHEKLYLTDPRrfs--tknQLIWKMHLGVTNMMTSFQELIKTLRYVDFEG 429  Trypanosoma b...
XP_001487248  750 KALTQYQSKYESVTTRFTKHFLKFMESQFDLLFEQLNSASD--------KFYPSAIYHELSNQLIYSSFVFFLKDVSISD 821  Meyerozyma gu...
EAZ63010      791 RALKQFDATYERVTSSFIKNFIFFAKSQFKMLIEQASSDLI--------RFKPHILLRELNNMLIYTGITYFVKECGAIE 862  Scheffersomyc...
Q6FRC5        801 EALRQRREFYERVTKLLIDRMVDELGRRFSNLHNS--------------STSSEQVMNILNNLLVFSPLILFCKIMSPES 866  [Candida] gla...
EDO14650      925 HALAPRRQAYEKVTKVFLDRVVQELGRRFANFQSD--------------VTSDDQLTNILGRLLIYSSLTSFCKDISPER 990  Vanderwaltozy...
Q6CQX3        693 RALSERRHAYEKVTELFIERIVEQMSLKFKEI-----------------EKSTENTKEALTNTLVFSSLTLFCKDVSMKS 755  Kluyveromyces...
Q54NV1        254 MAVKDQRKVFETYKISFARKVAALVENIFKTTDKEIGKHVItttsqtpgEEKFPDYLEYYDLLRKFKPLVNWLKEMDHEK 333  Dictyostelium...
XP_001636490  309 SAVKEQQERYKKVCQGFALRLKHHLLGIF----PQHGLDSEtpvr-yssEMHLPKHLNCHKDLLPYTGLMKWLKVVDQEL 383  starlet sea a...
Q9VVG4        344 EAVQDQRKRFEKWKQKFSATVSRFMNNLF----IHLGNEIGdmqv-tstELTLPNHSNVHRELTPYTELMHWTKAMDRKT 418  fruit fly
XP_005160613  333 MAIKQQQHLFSELRDTFARRLTNHLNNVF----VHQGHDQSstlaqhtaELTLPKHSPLHRDLLRYAKLMEWLKNTQREK 408  zebrafish
Q57ZX4        430 FIAVLRRYRVCMQRVYAREMQNFFKYLRGQLKkvgshrpfligvrdssdgivfsgsestRSETPHRRGSLANSDglrwtp 509  Trypanosoma b...
XP_001487248  822 FLDLNGIFTEKMSTILEKVLIGRVRTIKNSST-----------------------------GVSHVSKVLEQTL------ 866  Meyerozyma gu...
EAZ63010      863 FQELNQFFNALISNFLESLIKSKLKRINYSNN----------------------------------SNSTASNG------ 902  Scheffersomyc...
Q6FRC5        867 YEKLLELWNANSQAIHKTIWDKEFAKLDKNEI----------------------------MELKANHAILMEKG------ 912  [Candida] gla...
EDO14650      991 YTEIIDEWTDDIQPVYTGRFSKIFGKLDLKIS---------------------------EVQDIQEEAPIHQQQ------ 1037 Vanderwaltozy...
Q6CQX3        756 YEELIDLWNEDIYQLYERKTNILLSRMRPVAV---------------------------SQNSQLSQLSFNQSE------ 802  Kluyveromyces...
Q54NV1        334 LIPLIVSYIKAFRRIYESDIKLFFSTIQQSLE---------------------------KESKDQNDFFSSSSSskksid 386  Dictyostelium...
XP_001636490  384 FMDLCLAYIQSLNKVYEREVKEFFESAKQRLStkggtrsaiatfkmtvaspaksredtaSLRSSPRPSPRVSTH------ 457  starlet sea a...
Q9VVG4        419 YDGLMRVYTASLSKIYDRDVRNFFNLAKIQVTe--------------------------KLRNSREDLDMSTSS------ 466  fruit fly
XP_005160613  409 YEGLSRTYMDYMTRLYEREIKDFFEVAKIKMAgtskdgkgkfatl--prkesalkqeteSLHGSSGKLTGSTSS------ 480  zebrafish
Q57ZX4        510 tcSPLGYPHSFCHMSGSFSRLnisaptegqlfvdlpvacDDTLRLYDPIhtqaanvghnspTPAPSlla--ptvSKTNGQ 587  Trypanosoma b...
XP_001487248  867 --TRRSRTLRLSARKERFLHK------------------RSLAEGLP-----------------EFhvd--tisNKNSSE 907  Meyerozyma gu...
EAZ63010      903 --LSQVLDE-NHLRKSRTLRL------------------SRKRFGLNMEes--------ddHKQQAhlenvrkySKNSNE 953  Scheffersomyc...
Q6FRC5        913 --TEQLLKQWKHFKTTRKTTT------------------DEPIYG----------------------------------- 937  [Candida] gla...
EDO14650     1038 --ESTFITQWIKFKKDKKVMA------------------ETPIIV----------------------------------- 1062 Vanderwaltozy...
Q6CQX3        803 --QDSLYQWWYTLRIQKAPFQ------------------DSSELD----------------------------------- 827  Kluyveromyces...
Q54NV1        387 slNNNTSTSTPSKNSSSSSSS------------------SSGKDG--------------------------------IKK 416  Dictyostelium...
XP_001636490  458 ----------RFGRRDRKDTG------------------DSGSETRSRSgsi-------gsVDSAT--------EPLDIR 494  starlet sea a...
Q9VVG4        467 -------------RKSAVSTI------------------PYGTLGINRD------------QWGPG--------VETADR 495  fruit fly
XP_005160613  481 -------LNKLAVSSSNSRRS------------------QSSSLLDMGN------------MSASD--------LDVADR 515  zebrafish
Q57ZX4        588 LKPDVAFAMTLEAAFCMVLQEEDTLRRCF------GLVEGreecskgeenhhdftpsasdalsn-------vpesdkagl 654  Trypanosoma b...
XP_001487248  908 VEDPRAVIELLNETKDLITVLQFFLASMF------HYDNN---------------------------------------- 941  Meyerozyma gu...
EAZ63010      954 IEDPKAVVAIIDESKDLISIIQFFVGTFF------HYDRD---------------------------------------- 987  Scheffersomyc...
Q6FRC5        938 -DILVSVLEMLESLQKQCIYYQNFIDLYF------HISS----------------------------------------- 969  [Candida] gla...
EDO14650     1063 -NVLSEFMSLINKVENLCIVYQNFIDSFF------HISS----------------------------------------- 1094 Vanderwaltozy...
Q6CQX3        828 -PQLVSIINAIREMESVCTVYQNFVSSFF------HLSS----------------------------------------- 859  Kluyveromyces...
Q54NV1        417 RKINRLFKYALSCLEIYIMTKQNFVMDFFlyqdppRLAGQrnhhsnssgggsgsnkdgkdrkdkksskkdkkdkkdkkdk 496  Dictyostelium...
XP_001636490  495 GRFDRVFDILLSELEPVCTSEQEFIQKFF------DLSA----------------------------------------- 527  starlet sea a...
Q9VVG4        496 MRFDALLEKVLAELEPIALQEQLFCINFF------QMDVIspttkn---------------------------------- 535  fruit fly
XP_005160613  516 TRFDKIFEQVLSELEPLCLAEQDFISKFF------KLQQIptla------------------------------------ 553  zebrafish
Q57ZX4        655 lresllelfggdkvVQFYSGALNTAAPSAKHSeKDDVPSARVDvdcdtttadKNEGKVcTKLEKGQEDAQKGcyLQKELV 734  Trypanosoma b...
XP_001487248  942 --------------VLDFQDFMKQFPFSQRRRaLDNTTLDDAV----------TKTFT-NDLIANLNGVFGG--YLNVLL 994  Meyerozyma gu...
EAZ63010      988 --------------TFDYDEFMKVHPYSERRRmIDDFPSLNVEtl------nDNKNYStNELIGNMTTIFGN--FINIFM 1045 Scheffersomyc...
Q6FRC5        970 --------------TQNFTEAIKAKYSPEYNH-SLLASIHCIE---------SDREAA-VKKMDIVSKAFQS--VVTSIS 1022 [Candida] gla...
EDO14650     1095 --------------DLDFNEFLKQRRNPNFKT-PSLVELKVVE---------SDRELT-LMKTQLVSKVFQS--IIPQIS 1147 Vanderwaltozy...
Q6CQX3        860 --------------RLHFNEFVGSISPNERGF-TDLQKVGPME---------SVRKYA-TNINQLVSKIIQN--QLVKFF 912  Kluyveromyces...
Q54NV1        497 kdkkkkdpdsssspSLDNDKPIDSNSPKSPNNaVNGSLSSTEEsspppppppPPKESPdAPLDLILSAMFNG--VVPELI 574  Dictyostelium...
XP_001636490  528 --------------DEFDMRGLGPLGH------PLATPLPPTT----------------LSCRKVMQGLFSV--LEVELN 569  starlet sea a...
Q9VVG4        536 ---------tqttlEMEKAVDMTQSIISGAVS-PSGDGVPQKR---------IDRQIN-EDVRKLMMGLFGC--LEPELV 593  fruit fly
XP_005160613  554 -----------qgeNMDDSDGLMHSKPVSEHR-HSISE-------------------K-DMVRMMMNKIFQS--IETELN 599  zebrafish
Q57ZX4        735 DLVQYIgERCDRLnalpAMVMIKAYRREGTP--T--ASSsFCQSILQALEPIVASLISQSIMEQTASIKTcVRRYVVDps 810  Trypanosoma b...
XP_001487248  995 QKVNVA-DLTLPV----ILAYLETYILENEE--N--HENiFCVDVFKKISEKYKGNWNKFVRTQVEIINK-STVVAGC-- 1062 Meyerozyma gu...
EAZ63010     1046 KRVNPV-ELNIPL----ILIYLETVSNSTQS--T--NQEfLLFNFLKKSIEKYKNTWTKFIEGQIELLNN-SLVVAKS-- 1113 Scheffersomyc...
Q6FRC5       1023 VKISDI-LKEENSvapaLMLYLEQKIKELES--T--NQD-YLSSAYNRLLAQINQSWSEFLEESLVQMER--SFHGASls 1094 [Candida] gla...
EDO14650     1148 EDLNKI-FTFNKSiapsILLFLENKIQEIQS--S--NQE-FLLSIMTRLSTQVKQLWAEYVDDQVMNYER-VVMNFSGq- 1219 Vanderwaltozy...
Q6CQX3        913 KVVYKV-AANNRVdnpaLLLYLECRIKDLES--S--DQE-VLRNYLIKAYQRIQQDWSNYVDEQCVYIER-AVINFKSr- 984  Kluyveromyces...
Q54NV1        575 NMVEKA-DQVNPFylltMLLETELYIDAHSRkdS--HHSsYFVKILAEVQKSIKTLFNKFLEVQVDAIKS-TQTSLKRc- 649  Dictyostelium...
XP_001636490  570 AFIQFA-DKLDSFntmyMLVRIGQYVISNQL--SgaPVS-YLSQQLGNCLIVVKRLFDKFIANLKKQIEE-VRIQKNKrc 644  starlet sea a...
Q9VVG4        594 SFIQSF-ERVDSFyslyVFVRLTQHV-MSAQ--D--THS-FLSMTFASALVQVKRSFDRFMQNQLLSIRE-AKLHKRSk- 664  fruit fly
XP_005160613  600 SLIALG-DKIDSFnslyMLVKMSHHV-WTAEnvD--PAS-YLSTTLGNVLVTVKRNFDKCISAQIRQMEE-VKISKKSkv 673  zebrafish
Q57ZX4        811 GLLSCFSGLPTLVQRLETMHDSLPVAvrthseyaSVVLTLVDQCFESL--NCITNLAKSEANYEVKlsrlecivrranri 888  Trypanosoma b...
XP_001487248 1063 GVLPSMKNAVQLLLVAESSLEQTSRGmne--psdTLTRSLLDDTYKQLteAIIHLFMRDDPLLKKH-------------- 1126 Meyerozyma gu...
EAZ63010     1114 GVLPSVKNVNQLLLITESSLENNREIr------nTSVRSMVDLSYKQIteALIHLFMRDDPLLKNN-------------- 1173 Scheffersomyc...
Q6FRC5       1095 DALTVINNTAVYMKNIQDLFEYIQSQmkientntFDTVSIVETGCTTLtlRVSKILDRKNDGGSIIsg------------ 1162 [Candida] gla...
EDO14650     1220 TLAPSILSLPIFIKNARDLMAFTQHQvkvdeisvLTTEDITKNAFEKLstSVTQILCRGNTDTGSTssv----------- 1288 Vanderwaltozy...
Q6CQX3        985 SLSQSVVSLPIFTRSVEKSLRATVAWlcldentkYDSMLYSEQAYMRIaeSTVKLLLSSTNQDINTdm------------ 1052 Kluyveromyces...
Q54NV1        650 GVLPHFRNFHIFVKELQKYKSESDT---------GSSTLLIESSYKKIilELFNWLDGLVEKLPED-------------- 706  Dictyostelium...
XP_001636490  645 GILPFVAKFEEFAEISEGIFKSAER---------RTD---LDRAYHQLikVVFDNVERVA-------------------- 692  starlet sea a...
Q9VVG4        665 AILPYVENFENFAQTAEGIFRKSDR---------RTD---MEKWYLQLvnAIFEGIQLHS-------------------- 712  fruit fly
XP_005160613  674 GILPFVTGFEEFAKLAEAIFRNAER---------RGD---LDKAYIKLmrAVFNNVEKVA-------------------- 721  zebrafish
Q57ZX4        889 fnaGGENAKSAEHGFLQQyrhqAFFCLFYESLHPMSNa-vELLRERYDSSCALRDRYRELYLTrAVLVKEFPEFGPFTLV 967  Trypanosoma b...
XP_001487248 1127 ---EFDDKERELRNVSIL----QNLFYVTEQLSVFNL---KRVNSMRSQLGGIFNKVQDVYFQ-KILSKSIGKLIEFVTN 1195 Meyerozyma gu...
EAZ63010     1174 ---DLDDKEREYRNVSII----QNIYYILEQLDSVNNg-tSSTRDMNARLETVFKKVEDTYFQ-KLLTKNIGKLIEFVNN 1244 Scheffersomyc...
Q6FRC5       1163 -iqGNNSQEDIENTIALI----INSNSMVEFLMVLNNymgGILESSLQESKNIFDCEKEIYAA-YILRETMPKLTSFVNG 1236 [Candida] gla...
EDO14650     1289 -heKTIGRHDINKTMTLL----VNSFWLRETLPMVNDq--GTFDIPIRSAKEVFDREKVLYAQ-HLLQDAMPKLSSFVNG 1360 Vanderwaltozy...
Q6CQX3       1053 -vqNTNMSEKLDETVTLL----INTNLLLETLPLFDM---DIFSVTIQETKRLFDKEKESYSE-MLMNSSMPALVAFVQG 1123 Kluyveromyces...
Q54NV1        707 ---------KKYKFISKL----ENHYFFYLKLQELNI---NCLTQHKDTSQSIFKENLEIYVN-FLIDLKFKPLIEYYTK 769  Dictyostelium...
XP_001636490  693 -----AEHVKSPRAVVTL----ENYHHLFRVLSRLKI---SCLENERRDAKQKYNVSLDAYVR-EMLGRPMEKLNIFFEG 759  starlet sea a...
Q9VVG4        713 -----QEHPKTPVQVVRM----ENYHHMYALLAQLKV---PGLDALKKEAKKCYNDALKAYVT-QYFGRPLEKLNQFFEG 779  fruit fly
XP_005160613  722 -----NESQKTPRDVVMM----ENFHHIFSTLSSLKI---SCLEAERKEAKQKYTEHLQSYVI-NSLGQPLEKLNHFFEG 788  zebrafish
Q57ZX4        968 AEDLAQVhtpdd---lrshaAFSVSALQLLLTS-LPEEIRSGIPASSGRMKKHFLRDVARRknevALHCTLLQRAWSDFS 1043 Trypanosoma b...
XP_001487248 1196 YESLSNMgdg-------kskKYNKKYVKTLLSAyTNKDVTAKAQELHKKLEKHFVTGND------MLEKDLLDRLWKDME 1262 Meyerozyma gu...
EAZ63010     1245 YEALDKLnr---------pkKYNKKYVKSLLASyTQKEVSLKVHEIYKKLEKHYVTGSD------MFEKDLVEKLWEDME 1309 Scheffersomyc...
Q6FRC5       1237 ATNMLNTqsamn---narfaAYSKHNLQNILAGySSKDIGVIIEKFHQRIIEQFNPNGELN----PMEIVLCDKLWSCLQ 1309 [Candida] gla...
EDO14650     1361 ASNVIETsnfqntvnpsrwaVYSKQNLDNILAAyTSEEIELLVSSLHERIQKQFNRDLNRE-----FSNALCEKLWSCIQ 1435 Vanderwaltozy...
Q6CQX3       1124 AYSLIETsggngfvdpkqwaAYSEQNLSKILVSyTSQEVTALIGKLYNNMEAHFLSEANNK-----ARDVLCQKLWSNIQ 1198 Kluyveromyces...
Q54NV1        770 MDELLLTlppsd---iqfqqSHSKQQFKKIVEKfKTENIEKGLLKALGNVQKNI-----------TKDSQLILVIWERLE 835  Dictyostelium...
XP_001636490  760 VQERITagvkae--evgyqlAFSKQELRKCIKEyPSKEVKKGLEHLYKKVEKHL-----------CDEENLLQVVWHNMQ 826  starlet sea a...
Q9VVG4        780 VQLKVAqgvket--eisyqmAFSKQELRKVIAQyPAREVKKGLENLYKKVEKHL-----------SEEENLLQVVWHAMQ 846  fruit fly
XP_005160613  789 VEARVAQgvreee--vsyqlAFNKQELRKVIKEyPGKEVKKGLDNLYRKVDKHL-----------CDEESLLQVVWHSMQ 855  zebrafish
Q57ZX4       1044 AMFLQKFDFLESILQwSMYAN 1064 Trypanosoma brucei
XP_001487248 1263 RKFADYFTRLNNILR-HDFDR 1282 Meyerozyma guilliermondii ATCC 6260
EAZ63010     1310 NSTVNYFTRLNKILR-NDFDR 1329 Scheffersomyces stipitis CBS 6054
Q6FRC5       1310 GNTVSLYLKLQTLIE-KVYPG 1329 [Candida] glabrata
EDO14650     1436 GETVSLYLKLFTLID-KHYVG 1455 Vanderwaltozyma polyspora DSM 70294
Q6CQX3       1199 GKVVSFYLMLYSLIE-KHYKN 1218 Kluyveromyces lactis
Q54NV1        836 EVFIEKYEHFQDITS-DCYNQ 855  Dictyostelium discoideum
XP_001636490  827 EEFIQQYKHFEDLIS-RCYPG 846  starlet sea anemone
Q9VVG4        847 EEFIAQYNYLEERIQ-KCYAG 866  fruit fly
XP_005160613  856 DEFIRQYKHFEGLIN-RCYPG 875  zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap