Conserved Protein Domain Family
Es2

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pfam09751: Es2 
Nuclear protein Es2
This entry is of a family of proteins of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong. Apart from a predicted coiled-coil domain, no other known functional domains have been characterized. The protein appears to be expressed in the nucleus and particularly highly in the pons sub-region of the brain. The protein is clearly necessary for normal development of the nervous system.
Statistics
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PSSM-Id: 401630
View PSSM: pfam09751
Aligned: 59 rows
Threshold Bit Score: 196.122
Threshold Setting Gi: 302846606
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS72291      47 KQAILTEEEYTCALSSIIKRDFFPDLDRITAENEYLAAVEAEEPARIRIALDRLLRLDgrtnASPAPQRA------SKRS 120 Ustilago maydis...
XP_002954839  37 QPIVLDEDTYTQQLEAIIERDYFPELPKMVNQLEWLRAVNSGDIREMQRAQRNIARRRaaaaAAVAAAAGatpapgSIGG 116 Volvox carteri ...
Q656K0        54 RPEVLDEDTYVAAVERIIERDFFPDLPRLRDRLDWLQALRSRDPLVLRDAQLKILERRrraqRQRQGGPVp--------- 124 Japanese rice
XP_002272703  42 EVTVLDEDTYVAAIEKIVERDFFPDIPKLRDRLEWLEAVRSGDPLRIRDVQLKIRDRRgrkaLNCAETERn--------- 112 wine grape
XP_002301584  44 HPTVLDEDTYVATIEKIIERDFFPDISKLRDRLDWLEAMKSGDPIQIRDAQLKIMERRgk-kVNNPSSDGsfrsrnR--- 119 black cottonwood
XP_002533868  45 RARVLDEDTYVAAIEKIIERDFFPDISKLRDRLDWLEAVKTGDPIQIRDAQLKIIERRgk-rVNSSNSDGstqtrnRSQ- 122 castor bean
Q9S7V6        44 RMRVLDEDAYVEAIEKIIERDYFPDITKLRDRLDWIQAVKTRDPIQIRDAQLKIIERRgk-kANHHVGDTeg-------- 114 thale cress
XP_003544200  38 HPAVLDEDTYVEALEKIIERDYFPDISKLRDRLDWLEAIKTGDPVVIREAQLKILERRagtaKVTNHNDTsr-------- 109 soybean
EDQ57272      52 SQIPLDEDTYVAAIEQIIERDFFPDIPKLRNRLEWLEAVRSGDPVIIRDAQMNIIRRRrekaREDGERDGtps------- 124 Physcomitrella ...
XP_009147027  40 RMRVLDEDAYVAAIEKIIERDYFPDISKLRDRLDWLQAVKTRDPVQIRDAQLKIIERRgk-kANHQGGDTvg-------- 110 field mustard
KIS72291     121 r-----nHlsrasaaarndsgewDNTPIA-----F---GSssevfdptfTP-AESTIWLDHQGEPQHEaeaea------- 179 Ustilago maydis...
XP_002954839 117 dtpgllpP---------------FHTPGNgagwaTatpgt-----allrTPaMTPAVGGGGTGTEAAAaaaaanvaavag 176 Volvox carteri ...
Q656K0       125 -----------------------TPTPATstalrSpsf---------laTPsVAPSVAGDEGADV--------------- 157 Japanese rice
XP_002272703 113 ----------------------rSRTPGStf-trTftpFEld------kTPdVSNRESSVAGESAD-------------- 149 wine grape
XP_002301584 120 -----------------------TQTPGStf-mrSltpFDefds--riqTPgVVMDRGLSSNAESNEN------------ 161 black cottonwood
XP_002533868 123 -----------------------TQTPGStf-mrNlnpFDefdiinsnkTPrMDMFGDKEKSDNNDEA------------ 166 castor bean
Q9S7V6       115 ----------------------kTQTPGStf-lrNftpLDefd----gkTPrTPGVSGREFHGVEVDAgd---------- 157 thale cress
XP_003544200 110 ---------------------ttSHTPGStf-vrNftpLDefdg-kpsqTPrAPAPEAKEGENN---------------- 150 soybean
EDQ57272     125 --------------------tniPDTPASmis--------------glaSPaVSLRSAASPSVSGLFPptgsa------r 164 Physcomitrella ...
XP_009147027 111 ---------------------nkTQTPGStf-lrSftpLDefd---gskTPrEVEVVV---------------------- 143 field mustard
KIS72291     180 apasGIHPDLDLSLAHFQSRYTSEDNASFSQLLDRDNELRK-RKHAHLFAHE-AASGKRrqqlidaerRDAErgkrlmle 257 Ustilago maydis...
XP_002954839 177 gatsATATPDDLSLDAFLSRYTSEDNASFQAILQEDNRRKRaKVRHHLERPDpRDPETR---------QLLLegpk-drp 246 Volvox carteri ...
Q656K0       158 ----DDDVEAALSLDDFFRRFTSEDNESFSRILEKVNHRRR-ERYAHLLEPGeVAKA-----------PQLEdakr-dri 220 Japanese rice
XP_002272703 150 ----DDSEALPLSLDQFFRRYTSEDNESFSKILEKANRKRK-ERYEFLTEGEk-EDV-----------KLIEdvkr-dri 211 wine grape
XP_002301584 162 ----EVAVDKNLSLDEFFRRYTSEDNDSFSKILEKVNRKRK-ERYEHLLEGEk-EDV-----------KFIGdakr-dri 223 black cottonwood
XP_002533868 167 ----DDAVDEFLSLDEFFRRYTSEDNESFSKILEKVNRKRK-ETYGHLLEGEk-EDV-----------KLIEdvkr-dri 228 castor bean
Q9S7V6       158 ---gDEDIDLNLSLDEFFRRYTSEDNESFSKILEKVNRKKK-EKYGFLLEGEk-EDG-----------KSIEdvkr-dri 220 thale cress
XP_003544200 151 ----DGGVDTSLGLDQFMRRYTSEDNHSFSKILEKVNKKRK-ERFGYLNE-----DV-----------QGIEdvkr-dri 208 soybean
EDQ57272     165 dvdnGPSVDVNMKLDDFLRKYTSEDNASFSKILEKVNKQRK-QKYEFLNEKGlVD-------------PNLRienandrv 230 Physcomitrella ...
XP_009147027 144 ----ANDGEFNMSLDEFFRRYTSEDNDSFSNILEKVNKRKK-EKYGYLLE----KDG-----------DLIEdvkr-dri 202 field mustard
KIS72291     258 ASPDDSNmseeatemlliegsdakveeksataaavtvtgqrpetssekdpmddlvlvceprqDDRRTASglHRWKYTARN 337 Ustilago maydis...
XP_002954839 247 SDEYGTS-------------------------------------------------------GQMPMTLlpAP--EPVVN 269 Volvox carteri ...
Q656K0       221 TDGYGTS-------------------------------------------------------GQPLSTL--EGAKFTAKN 243 Japanese rice
XP_002272703 212 TDGYGTS-------------------------------------------------------DQPPSTL--DGWKYTAKN 234 wine grape
XP_002301584 224 TDGFGTS-------------------------------------------------------DQPPSTL--EGWKYTAKN 246 black cottonwood
XP_002533868 229 TDGYGTS-------------------------------------------------------DQPVSTL--EGWNYTAKN 251 castor bean
Q9S7V6       221 TDGYGTS-------------------------------------------------------DQPPSTL--EGWKYTAKN 243 thale cress
XP_003544200 209 TDGYGTS-------------------------------------------------------YQPPSTL--EGWNYTAKN 231 soybean
EDQ57272     231 TDGFGTS-------------------------------------------------------NQPFATL--DTWKYRAKN 253 Physcomitrella ...
XP_009147027 203 TDGYGTS-------------------------------------------------------YQPPSTL--DGWKYTAKN 225 field mustard
KIS72291     338 ALMFGADANESYLHARPLGVTADHEAsRPQTNFTALRLgEQSNShtAVRHVDapQSEA---GWCASTSRLDAAIQr--GR 412 Ustilago maydis...
XP_002954839 270 ALFYDSSQRPEVPFSAKELADRALGP-PKEINRAGTRL----------KAPPeaPPLTvaaPVAAAAAAAAAALAngeDA 338 Volvox carteri ...
Q656K0       244 LLMYYPADRGEAPLTDEERAERLKGM-TKEIDRSNTRF-HGKSSv-DDGAKEeeAAAIlyaPVAGSTP---GGMAyhdPD 317 Japanese rice
XP_002272703 235 LLMYHPADRGEAPLTEEERAERLNGL-TKEVNLTNTRF-HGKLM--DSRPKDedTVAVlytPIPGATP-VPLSLSereGD 309 wine grape
XP_002301584 247 LLMYHPADRGEAPLTEEEQAVRLKGL-TKEINRSSTRF-HGKML--DTRPRDdgVVEVlytPVAGATP-LP--MYdrdGD 319 black cottonwood
XP_002533868 252 LLMYHPADRGEVALTEEERAVRLKGL-TKEINRSNTRF-HGKML--DSRPKDdgSVEVlytPVVGGTP-LP--VSgrhGD 324 castor bean
Q9S7V6       244 LLMYHPADRGEAPLTEAERAVRLLGL-TKEIVKGNTRF-HGKTM--DSRPREdgSVEIlytPIAGSSP-MH--ISgrdRD 316 thale cress
XP_003544200 232 LLMYHPADRGEVPLTEEERAHRIKAA-TKEINRGNTRF-HGKMM--DSRPKDdgTVEVlytPVGGATP-AP--MSlreGD 304 soybean
EDQ57272     254 LLMYDSAEREDVPLTQAEKEELVEGP-PKSIEMKNTRF-HGKMF--DSKVREedTVAIlytPVAGGTPQAWPFAQrdaER 329 Physcomitrella ...
XP_009147027 226 LLMYHPADRGEWPLTQEERAVRLAGL-TKEIVKANTRF-QGKTM--DCRPREdgSVEIlytPIAGSSP-MQ---QvrdRD 297 field mustard
KIS72291     413 AGSFTS-------PVasaSGDETPK--------VN--GYGFVTpysTPQsgnsqsvdgemhlRVYNAikrsrQHHVTAst 475 Ustilago maydis...
XP_002954839 339 AAAAAA-------AAaaaAAAGAPAgapmpgglIGtvGYAPMA---TPAle----------dVMASPlmtwgDIESTPlr 398 Volvox carteri ...
Q656K0       318 KAKKYDledlrktPNpfyVESGKNA--------NN--GYSFVR---TPSpa---------pgVDESPfmtwgEIDGTPlr 375 Japanese rice
XP_002272703 310 KSKKYDledlrktPNpfyVESRKRA--------DN--GYSYVK---TPSpa---------pgVDESPfitwgEIEGTPlr 367 wine grape
XP_002301584 320 KAKKYDledlrrtPDrfyVESGKKA--------DD--GYSFVR---TPSpa---------pgVDESPfitwgEIEGTPmr 377 black cottonwood
XP_002533868 325 KAKKYDledlrrtPNnfyMESGKKA--------EN--GYAFVR---TPSpa---------pgVDESPfitwgEIEGTPlr 382 castor bean
Q9S7V6       317 KSKRYDlddlrktPNpfyVESDKRA--------DN--GYSFVR---TPSpa---------pgLDESPfitwgEIDGTPmr 374 thale cress
XP_003544200 305 KLKKYDledlrktPNpfyLESGKKA--------EN--GYSFVK---TPSpa---------pgVDESPfitwgEIEGTPlr 362 soybean
EDQ57272     330 ARKRYDledlrktPQaldSQSKGVG--------HPgaGYSYVA---TPSpa---------pgVDESPfmtwgEIEGTPlr 389 Physcomitrella ...
XP_009147027 298 TSKRYDlddlrktPHpfyVESDKKA--------GN--GYSFVK---TPSpa---------pgVDESPfitwgEIEGTPmr 355 field mustard
KIS72291     476 sidd--------iaaraCGFQLPRLDKREQLAEKLTSTPklkrAAE---------------------------------- 513 Ustilago maydis...
XP_002954839 399 lgaddmpvdleamvgggPSFRVQGMSEREQAAHRLAAAKagsgTAAgraitargstplltalrraatgtgggagatarag 478 Volvox carteri ...
Q656K0       376 ldpeetp--ggsggsdrAHFKIPPPPARDVKAHLLSRDA----ARKikertkmfhk-----------------pplpspv 432 Japanese rice
XP_002272703 368 lepedtp-igiggsgdgPHFKIPCPPSRDLKAHSLSREA----ARKlrerskmfqk-----------------pplpspv 425 wine grape
XP_002301584 378 lepedtp-idiggsgngPHFKIPNPPARDVKAHSLSREA----SRRlrekskmfqk-----------------pplpsps 435 black cottonwood
XP_002533868 383 lesedtp-idiggsgdgPHFKILNPPARDVKAHTLSREA----ARKlrerskmfqk-----------------pplpspg 440 castor bean
Q9S7V6       375 ldledtp-idiggsadgPHYNIPSAPPRDVRAHSLSRDA----SRKlrersnsmfk----------------kpplpsph 433 thale cress
XP_003544200 363 ldledtp-ldiggsadgPHYKIPSAPARDSKAHSLSREA----ARKirerskmfhk-----------------pplaspv 420 soybean
EDQ57272     390 leiedtp-vgiggngdgPHFKIPAPPTRDARAHALSRDA----ARSlrekakfrss----------------rfspspgr 448 Physcomitrella ...
XP_009147027 356 ldsedtp-ldiggsadgPHYNIPLAPQRDVRAHSLSRDA----SRRlrersnsmfkk---------------pplpssph 415 field mustard
KIS72291     514 --RASTPygqarytgltrlrtsafgrspqkmrdKVGGLTPAAKAL 556 Ustilago maydis 521
XP_002954839 479 atGGKTP--------------------------LAVPLSPAARQL 497 Volvox carteri f. nagariensis
Q656K0       433 rgGSASP----------------------------RTFSPAAQKF 449 Japanese rice
XP_002272703 426 rgGSASP--------------------------SVRTLSHAAQKF 444 wine grape
XP_002301584 436 rgGSASP--------------------------SVRTLSPAAQKF 454 black cottonwood
XP_002533868 441 rgGSASP--------------------------NVRTLSPAAQKF 459 castor bean
Q9S7V6       434 rsGSASP--------------------------NVRTLSPAAQKF 452 thale cress
XP_003544200 421 rgGSASP--------------------------SMRTLSPAAQKF 439 soybean
EDQ57272     449 gpGQASP---------------------------APGFSAAAQKF 466 Physcomitrella patens
XP_009147027 416 rsGSASP--------------------------NVRMLSPAAQKF 434 field mustard
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