Conserved Protein Domain Family
LRRFIP

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pfam09738: LRRFIP 
LRRFIP family
LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
Statistics
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PSSM-Id: 401617
View PSSM: pfam09738
Aligned: 19 rows
Threshold Bit Score: 265.759
Threshold Setting Gi: 675882290
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009026647   44 S--------AVLAEARKLRLDEREKHKKEnedVDEDDDEESTENSKQSADntanieNIPASKVPTTATTTTSTTSTTSQP 115  Helobdella ro...
EEC04563       21 AearlaqrrQARAEARAIRLRELEKQARE---VIRPVRTSREVSSASALLp-----ESDARPGLPPQGRTSSFVSSSSFS 92   black-legged ...
XP_011142076   29 AearlaarrQARAEAREIRMRELEKQQKE---AEENADRVYDMCTADVN--------RTMRVTPDPVRTSRLLTNSNNFQ 97   Jerdon's jump...
B2GUE2         31 AearlaakrAARAEARDIRMRELERQQKE---LDEKIDKQFTENYSR------------PSSRNATSGI-PGTFTPLSGS 94   tropical claw...
XP_010833834   31 AearlaakrAARAEARDIRMRELERQQKE---LDEKSDKQYAENYTR------------PSSRNSASAT-----TPLSGN 90   Bison bison b...
NP_001104782   33 AearlaakrAARAEAREIRMKELERQQKE---VEERPDKDFA-----------------EKGSRNMPSLSAATLASLGGT 92   house mouse
XP_005167696   31 AearlaakrAARAEAREIRMKELERQQKE---VSDDEERMSVGSRSNVRAddrlerDYLEKGSSRASTISGTTLTSLGGT 107  zebrafish
5_pfamImport    1 AearlaakrAARAEAREIRMKELERQQKE---LSDDDERMSVGSRGS------------VRGSRAASALTAATLTSVGGT 65  
2_pfamImport    1 AearlatrrAERAEAREIRMKELERQQKE---VEEKPDRDFV-----------------DKGSRTASTLSAATLASLGGA 60  
XP_031140067   31 aearlaakraaraearDIRMRELERQQKE---LDEKCDKQYT-DFSR------------PSSRCATPGLSAATLASLGGT 94   pike-perch
XP_009026647  116 ITRMHSTtDSRPVLEHsssrQQD------------------------TTGSADLMEKYKKVLLSNAQLDNEKRALKYEVD 171  Helobdella ro...
EEC04563       93 SSRRSSE-DSTEALDG----RDF------------------------RHQLQEVEESFRKAMISNAQLDNERTALAYHVD 143  black-legged ...
XP_011142076   98 SSRRSSE-DS---LEDaglsRDI------------------------RLELKEFEEKFRKAMIANAQLDNEKSSYAYQVD 149  Jerdon's jump...
B2GUE2         95 SSRRGSG-DANSSLDPdaslSEL------------------------RESLAEVEEKYKKAMVSNAQLDNEKSNLVYQVD 149  tropical claw...
XP_010833834   91 SSRRGSG-DTSSLIDPdtslSEL------------------------RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 145  Bison bison b...
NP_001104782   93 SSRRGSG-DTSISMDTeasiREIkelnelkdqiqdvegkymqglkemKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD 171  house mouse
XP_005167696  108 SSRRGSG-DTSISADTeasiREI------------------------KDSLLEVEEKYRKAMVSNAQLDNEKTNMMYEVD 162  zebrafish
5_pfamImport   66 SSRRGSG-ETAIAIDAetsiREI------------------------KDALGEVEEKYRKAMVSNAQLDNEKNNLMYQVD 120 
2_pfamImport   61 SSRRGSC-DTSFSVETeasiRDM------------------------KDSLAESEDKYRKAMVSNAQLHNDKSTLMYQVE 115 
XP_031140067   95 SSRRGST-DTGSIYDPdtslSEL------------------------RESLAEVEEKYKKAMVSNAQLDNDKGNLIYQVD 149  pike-perch
XP_009026647  172 LLKDRMCDVEESNLETKRSLRISNKEKDALLDQLRALESKCQKLTVDLIQRDHLIKTSGLALVTTDNTYTApedseytsg 251  Helobdella ro...
EEC04563      144 TLKDDMEEMAENYLQVQRDFREKARALDQLIRDFRKLKEENAFLEESLKQRDELIEDHGLVLKLVLVPKAQ--------- 214  black-legged ...
XP_011142076  150 LLKDKLEELEETTAQLRRELREKNRDVEQLKRVSQRLKEDLDFCRAQLYDRDELIKENGLVIVEYVSDDDYente--ngp 227  Jerdon's jump...
B2GUE2        150 TLKDVVEEMEEQMAEYHRENEEKSKELERQKHNCSILQHKLDELKEGIQQRDEFIEKHGLVIIPDGTPNGDinh----ep 225  tropical claw...
XP_010833834  146 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDvhq----ep 221  Bison bison b...
NP_001104782  172 TLKDMLLELEEQLAESQRQYEEKNKEFEREKHAHSILQFQFAEVKEALRQREEMLEKHGIILNSEIATNGEtsdtv-ndv 250  house mouse
XP_005167696  163 TLRDSLMELEEMLFETRRELEEKIKDLEREKHAHSILQFQFSELKETLKQSEELLSKHGIVLGPDLVTNGEtgde--vgn 240  zebrafish
5_pfamImport  121 TLKDSLMELEELLSESRRGYEDKVKEYEREKHSHTVLQFQFTEMKETLKQSEELLNKHGIVLGPDLNINGElgea--evv 198 
2_pfamImport  116 NLKAELSDMEELLWESRRHCDDRTKEFERELQAHRVLQFQFKEAEEALRRTEELLTKHGVVVPPENSTNGDrg------- 188 
XP_031140067  150 TLKDVIEEMEEQRAEMRRELEDKSKELERQKHTCTVLQHKQEELKEGIRQRDELIEKHGLVIIPDGTPNGDvnh----ep 225  pike-perch
XP_009026647  252 sNMSSAILTAEHLEILADY----TGSLGDRLKKLFDERNEILEEKEKISKELSELKSNSSNLLQQQQTSSFSTIAspvfd 327  Helobdella ro...
EEC04563      215 -AAKAALVSQEAAQLLDQAg---DGSLDVRLKRFAQEKQELQDEVGVLMEVQSECRPQARSTSARRLSLTFFVFS----- 285  black-legged ...
XP_011142076  228 cQPRRVLVSTEAAELLETAg---KGSLDVRLRKFASEKKELQDEIRHLRLELEETRSRVRSERSSGSVLGCLSDNd---- 300  Jerdon's jump...
B2GUE2        226 vVGAITVVSQEAAHVLESAg---EGPLDVRLRKLAEEKEELVAQIRKLKLQLDDERQ-RSAKNNSTTTDSTGLENgsdl- 300  tropical claw...
XP_010833834  222 aVGAITVVSQEAAQVLESAg---EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ-KCSGRDGTAGDLAELQNgsdl- 296  Bison bison b...
NP_001104782  251 gYQAPTKITKEELNALKSAg---EGTLDVRLKKLIDERECLLEQIKKLKGQLEGRQ--KNNKLDLLRAEDGILENgtda- 324  house mouse
XP_005167696  241 aDPNSQTASAEIREg--------SSVLGIHQLKHKD------QEQKYLDDEVQGNQQSSNALFSSTNPPLEANDNgvlgd 306  zebrafish
5_pfamImport  199 eTPGADHVTQPAADAQGAPte-gNSMLEIRLRKLVDEREKMIEQVKKLKSQLDLKTQ-RNGTDSSVSPDGEILENgndp- 275 
2_pfamImport  189 qGEGVDEVTADSASPEEPPpggrESALELRLKKLFEERESLRDQVRQLKSQLDRRQ--KNGTDEVQNPEGDHLEdsh--- 263 
XP_031140067  226 lSSGITVVSQEAAQVLESAg---EGPLDVRLRKLAEEKDELLAQIRKLKNQLEEERQ-KHSKMDSAYTDGERMENgtdl- 300  pike-perch
XP_009026647  328 givfD---DAHK-------------NFTEIKLKLKKAEQEITT 354  Helobdella robusta
EEC04563      286 ----LvpgEANK-------------QVDDYKYKLRKAEQENMT 311  black-legged tick
XP_011142076  301 ----DiqrEANK-------------LLADYKFKLQKAEQDMST 326  Jerdon's jumping ant
B2GUE2        301 -qliEmqrDANR-------------QISEYKFKISKAEQDMTT 329  tropical clawed frog
XP_010833834  297 -qliEmqrDANR-------------QISEYKFKLSKAEQDITT 325  Bison bison bison
NP_001104782  325 -hvmDlqrDANR-------------QISDLKFKLAKSEQEITA 353  house mouse
XP_005167696  307 svvpGvgqHENRteeplssvgdeevTATAPKEEVKSEEHELKd 349  zebrafish
5_pfamImport  276 -nliElqrDSSR-------------QISDFKFKLVKTEQEVTA 304 
2_pfamImport  264 --llDlqrDANR-------------QISDLKFKLVKSEQEVTT 291 
XP_031140067  301 -hviEmqrDANR-------------QISEYKFKLSKAEQEIGt 329  pike-perch
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