Conserved Protein Domain Family
CactinC_cactus

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pfam09732: CactinC_cactus 
Cactus-binding C-terminus of cactin protein
CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.
Statistics
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PSSM-Id: 401611
View PSSM: pfam09732
Aligned: 43 rows
Threshold Bit Score: 150.824
Threshold Setting Gi: 74777220
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKG13175                      366 WADKYRPRKPRYFNRVQMGYEWNKYNQTHYDH-DNPPPKVVQGYKFNIFYPDLIDKTK--A---PTYRIEREngrkrgqs 439 Macrophomina phaseolina MS6...
Q6CF65                        368 eikVDKKTRPRFHNRVVLGFDWNKYNQTHYDS-NNLPPKTVQGYKFNIFYPELPE-GK--T---PSYQVIKMkne----- 435 Yarrowia lipolytica...
Q8IAN8                        678 kdtlfVARKPLYFNRIKTSFDWNKYNKTHYDY-ENTPPKYICGYKFNIFYTNLINKNH--K---PTWKLYPS-------- 743 Plasmodium falciparum 3D7...
Q7RRC7                        173 knNLMVSRKPLYFNRIKTSFDWNKYNKTHYDY-ENTPPKYICGYKFNIFYTNLLNSNQ--K---PSWKICS--------- 237 Plasmodium yoelii yoelii...
Q5CRS3                        391 GYQITELILPCVYSMIKARYYWNQYNKNYYSN-ETLPPKIIQGYKFKIKYPLLGKAEN--SgiiPRWYITTKdkylkknk 467 Cryptosporidium parvum...
XP_001609365                  319 eyksstgPKPLFAARVTMSYEWNKYNLAHFDV-DNPPPKSVQGFKFSIFYSDLEDPKA--T---PQWKLVKD-------- 384 Babesia bovis T2Bo...
Q4UBY8                        393 tdENTDLKAPMYYNRVKKGFEWTKYNLAHYDQ-DNPPPKQIQGYRFNIFFPQLK--GK--V---PKWKLQKD-------- 456 Theileria annulata...
XP_001470276                  562 ggeaePLMKPHRFCKVKTGFTWTQYNRTHYDSrTNPPPRTEMWYEFTLFYPALANTKRdmR---HIFRIEDT-------- 630 Leishmania infantum JPCM5...
A0CV63                        524 WSQKYKLKRPQYFNRVKMGFDWNMYNKTHYDV-DNPPPKTIQGYKFNVFYPELIDKTQ--A---PKYTLET--------- 588 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00459380A 556 WSDKYKSKKPKYYNRVKLGFDWNKYNRAHYDS-DNPPPKYVQGYKFNIFYPELVDMQK--T---PEYFLEP--------- 620 Tetrahymena thermophila SB210...
EKG13175                      440 fapAGEED--TCLIRFIAG---------------------PPYEDIAFRIVDKEWDYSAKreRGFKSSFD-KGILQLHFQ 495 Macrophomina phaseolina MS6...
Q6CF65                        436 -diTKQRE--TCLLKFTAP---------------------APYADLTFRVVDRTWDYAARgdGKYNSSYH-NGVLQLHFR 490 Yarrowia lipolytica...
Q8IAN8                        744 ---KDDDT--KVIIIFHGG---------------------IPYLDIAFKIINAEWSLDKN--KGFRNIFD-RGILQLYFN 794 Plasmodium falciparum 3D7...
Q7RRC7                        238 ---CDEEG--AVLIVFHGG---------------------PPYIDIAFKIINSEWCYDKH--RGFRNVFS-RGILQLYFN 288 Plasmodium yoelii yoelii...
Q5CRS3                        468 llvTNE----EVLLKVHEDilfceneisvmnklliitcdhKIYKDVGFSIIDKEWDLNPR--SGFKSYFE-NSTLYLNFN 540 Cryptosporidium parvum...
XP_001609365                  385 ---GNSSE--TCLLVFKGA---------------------RPYAPLAFRIPAREWDTDPS--RGFKNCFS-DGVLHLYFN 435 Babesia bovis T2Bo...
Q4UBY8                        457 ---ENRTE--TVLIRFIGG---------------------HPYRDIAFRVVNREWNTDPQ--RGFKNFFD-NGVLHLYFD 507 Theileria annulata...
XP_001470276                  631 ---PEGPNdqYCLLVFSVG---------------------PPYADVAYRIRKKQWDTRR---GGVRISFDqYGRYKLFFR 683 Leishmania infantum JPCM5...
A0CV63                        589 ---CENPD--YCIIRFIAG---------------------PPYEDLAFQILCKEWDYSDR--MGFKSVFS-RGILHLWFN 639 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00459380A 621 ---TDEQG--YCIIRFTAG---------------------PPYEDVAFKIINKEWDYADK--KGFKCYFN-RGVLTLHFN 671 Tetrahymena thermophila SB210...
EKG13175                      496 FKKIYYRK 503 Macrophomina phaseolina MS6
Q6CF65                        491 FKKDFYKK 498 Yarrowia lipolytica
Q8IAN8                        795 FKKKRYRR 802 Plasmodium falciparum 3D7
Q7RRC7                        289 FKKKRYRR 296 Plasmodium yoelii yoelii
Q5CRS3                        541 FKQTKYKR 548 Cryptosporidium parvum
XP_001609365                  436 FRKLVYRR 443 Babesia bovis T2Bo
Q4UBY8                        508 FKKIKYRR 515 Theileria annulata
XP_001470276                  684 FTNSNYRR 691 Leishmania infantum JPCM5
A0CV63                        640 FKKPRYRR 647 Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00459380A 672 FKRSISRR 679 Tetrahymena thermophila SB210
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