Conserved Protein Domain Family
Cas_Csa4

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pfam09703: Cas_Csa4 
CRISPR-associated protein (Cas_Csa4)
CRISPR loci appear to be mobile elements with a wide host range. This entry represents a protein that tends to be found near CRISPR repeats. The species range for this species, so far, is exclusively archaeal. It is found so far in only four different species, and includes two tandem genes in Pyrococcus furiosus DSM 3638. CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.
Statistics
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PSSM-Id: 286749
Aligned: 6 rows
Threshold Bit Score: 326.455
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8U337          6 PMF-SGYYSRVLNTHIMYGIVESALRAGVTNLHVVPTGEGYEIHsr-----yLDCRLKNqedlegegcklLLEGLRDALE 79  Pyrococcus fur...
Q9YCM8          3 CILyTPGHNLYTDTLILYGIARLLAWSGKVSGEVERVGERYVVK--------VDADNCHpvsqlpesirlALRLLQEEQQ 74  Aeropyrum pernix
Q8ZZL4          3 KEIyTPGHDVFADTLIMHGVVRHLAASGIVEGYVERLGERYKISfegepralADIES-------------VELLLFEIER 69  Pyrobaculum ae...
jgi:Tpen_1355 116 PTLyTPGHSPYTDTLIMHALARAAWGARDAALRVRGTGFEYVLEt------sVDART-------------LAYELRRTFE 176
Q8U338          4 NEFkTPQIDPIFDLYVAYGYVESLIRGGAKEATLIPHGASYLIQ--------TDVSNEE-----------FRHGLVDALS 64  Pyrococcus fur...
Q57830         25 MLFeTPGYNEILDLYIAYGVVECLVREGVENLRFFPIGNKYCIVve----epTNVNIKNr----------IEKGMLNALE 90  Methanocaldoco...
Q8U337         80 EIIMTHYamgfrskkfnn-vilsntvisnGAFIDPPQNVQRYY-----RELEAILNNLDiKSLKSTKSLID--------- 144 Pyrococcus fur...
Q9YCM8         75 QVFLGDE----------------------GTFYSDLYRLARGS-----KVGESILNNLRiRVAAKILSNDAnilekyvsp 127 Aeropyrum pernix
Q8ZZL4         70 YVVDGEEpvgrlrki-------fdaniniSATRSWLAQLSEAL----------------------VNAELSvftldhkak 120 Pyrobaculum ae...
jgi:Tpen_1355 177 EV---HAafl------------------------drQRLGRLFqdkdvRLLDSAL-DPE-GLRAFLEGELSrpghag--- 224
Q8U338         65 EMLSLHIalarhspregg-klvsdadfsaGA------NINNVYwdsvpRNLEKVMKDLE-K-KRSVKGT----------- 124 Pyrococcus fur...
Q57830         91 DMLSLHKaigkyistkedikiisdvdfsaGA------NINNVYwdgipKTLEKIKENIK-KGKLSTKSK----------- 152 Methanocaldoco...
Q8U337        145 -------------KKVLRAPQQLDPTLNQWL--SFYKQ---EEGISRITNLEYALAWVGFYYYSSVHKf--KRGSSQIVe 204 Pyrococcus fur...
Q9YCM8        128 ghkklqgefrgrkKGLVTLVLPLGPLYGKFYtwSLKPRr-lTEKPYVVCPYCYFLSVLGFHYGSYTYQ---KDGESKVV- 202 Aeropyrum pernix
Q8ZZL4        121 -----fregrtasRRLSTVYLTLSPIYGKYFieNRVAK---ENKAFGVCHTCFAYLNIGFLYGATTIViitRDGRRVVQl 192 Pyrobaculum ae...
jgi:Tpen_1355 225 --------aegrgFDGLTFKLPLMPSAGKYLhtDLTRKpkyEAKEYRVCKYCAALAALGL---ASSVYv--ARGARVLVv 291
Q8U338        125 ----------------ATIPITLMPSAGKYMlkHFGVQ---GGNPIKVDLLNYALAWVGFHYYTPYIKy--AKGDTTWIh 183 Pyrococcus fur...
Q57830        153 ----------------NTVPLTLMPAAGKYMpkIYGVK---GGNPIKIDDSNYALAWIGFHYYAPYINi--SDNRATYIh 211 Methanocaldoco...
Q8U337        205 iiQYPPNEEv------EMWELLLIKDLATKI--VQGNdfhwKISSEYGLL-KTLLLTELPPSTEEVPGLSKFTVVIygQE 275 Pyrococcus fur...
Q9YCM8        203 --TLSPHHA-------SLEDVLALSQSFEAAsiWMPA----ILRYRNSLTgPGLSLYVLSLGETLLSSSSHFEVLY--GE 267 Aeropyrum pernix
Q8ZZL4        193 --TPAPRGRi------SIADLALLQRLTEGY----------LVRSQEMPT-LAYPLYWLSTGETLYATEESLDILVwvTE 253 Pyrobaculum ae...
jgi:Tpen_1355 292 --TLAFSGEagydalgGYYDFLQGEEAKDVLgvLGPR----VDNVPERLL-AQLAVALLTRNALEALDHAGATWRVyaVK 364
Q8U338        184 iyQIAPVEEv------DMISILSLKDLKMHLphYYESnldfLINRRLALL--YHLLHSESLGALELFTEKEFVIHSytLE 255 Pyrococcus fur...
Q57830        212 iyAIKPLEEl------GLIEILALKDLKKKInnYQLGkykfFVNKKLALL--YHLTHTESISALEIVTKKNFSVVSytLE 283 Methanocaldoco...
Q8U337        276 SQQGKGwr--iFRTLELPV----VWDFIGYLKARaFYETMKFVkilnklertikesqEDILRE----------------- 332 Pyrococcus fur...
Q9YCM8        268 FSVDNNt----FRVVDVGRlpgvLLTSIAIIKYH-MASWPRLI--------------DFIARRdp--------------g 314 Aeropyrum pernix
Q8ZZL4        254 -KRGNFqrvtdAMALDLSR----IMEFIAEVKNK-TRGWPKFV--------------ECLALEgp--------------e 299 Pyrobaculum ae...
jgi:Tpen_1355 365 FDTGRAvqvrgFYDVEVDS----VVGAMSSLARVdDASYSKL---------------RDMLKQlaratgadspragyale 425
Q8U338        256 -RSGNNqairsFEEEEIGK----LMDFLWKLKRRdFYHAIKFI--------------DDLLKKat--------------e 302 Pyrococcus fur...
Q57830        284 -NVDNNqairsFGEYDLSK----LMDFLWYLKATdFYNTIQFV--------------DNILRGdl--------------e 330 Methanocaldoco...
Q8U337        333 ISHQ--LYSAL-------TNRDEMGFYSAFRVLKRAG-YPLDPELVNAIAQYLSER 378 Pyrococcus furiosus
Q9YCM8        315 LLHRiaLTLSFevgneyaLYGILREILSLLNDDKSQE-ARYLAKQLDRLAEGLAMV 369 Aeropyrum pernix
Q8ZZL4        300 ILAQ--LTEVV-------LFGG--DEYTVVRALSTSGkCAEDWRQVDILAEILFTW 344 Pyrobaculum aerophilum
jgi:Tpen_1355 426 ALSR--LFEFFetaspdsLYGFARSVYCAYE--GKAG-------FHGVVESLVRAW 470
Q8U338        303 GALA--LIDAI-------MNERLEGFYTALKLGKKAG-VVSSREIVAALEDIICER 348 Pyrococcus furiosus
Q57830        331 VSLT--FIDGI-------LYDDLDAVYSAIR--KLKS-VRISPLIIQSILEWFGNf 374 Methanocaldococcus jannaschii DSM 2661
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