4JLE


Conserved Protein Domain Family
PRESAN

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pfam09687: PRESAN 
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Plasmodium RESA N-terminal
The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.
Statistics
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PSSM-Id: 401576
View PSSM: pfam09687
Aligned: 144 rows
Threshold Bit Score: 35.3353
Threshold Setting Gi: 74863823
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JLE_A         18 KYTAEEINEM-INSS-----N---EFINRNDMNIIFSYVHESEREKFKKVEENIFKFIQSIVETYKIPDEYKMRKFKFAH 88   Plasmodium fa...
Q7RNN0        825 KEMDDHINSK-ISAL-----D---VNTTPEALYDIWTDFIIAETKKFMLTQEYVLQYSIYLQKRNKLNPELRTKAWWKVF 895  Plasmodium yo...
EDL42944      572 QMTEEELNSK-IKNL-----R---PNATVKEMFVLFNQILSFERKKFVKMQEYIMQYSQYLQKTLLLPTPIRMKYWWRAH 642  malaria paras...
Q8IAK9       1081 KLTEEELNER-IRRL-----D---YTVSVKDMFILWNHILAHERKKYTKMQEYLMYYSQYLEKTYLVPTAFRKKYWWRVH 1151 Plasmodium fa...
XP_001612770  149 kkdlkkdltkdLKKEiwdtiDasgPDMTQEQMIQLYFELHDYLRRKFQIMVDELWLYTLSIAKEKHLREEYRSKYWWECS 228  malaria paras...
Q8I3F2         89 EYTPDEIRNI-MCTF-----D---KTVSKNVMYDTYYKLHDYQRKKFLRMVDEIWEFTITFAKENKISENYRSKYFWECN 159  Plasmodium fa...
Q8IHN7         98 leYTEELNEQ-ITSL-----D---PKTSIQELTNIFNDLNENRKKNFHYLIEALENVSLILAHQNDIPEKHRKSTWCKIK 168  Plasmodium fa...
EDL42369       39 velTEEMQDK-LKSCd--------PDITEKDMCKMYSKLYNEHISNFRHLVECLKTATDMLGTNYKQDPSFQKKCWFHQY 109  malaria paras...
XP_002257686  387 vyyTEEMKKRiFANG---------PVMTKKYMAEIFFDLCDEQKENFLFMKETMSKISFMLASQFKMPNEERSKCWTHLN 457  Plasmodium kn...
XP_002261677  194 DLEEEELFMK-IKSL-----K---GLINSNQMYSIWESVYALMRKKYFYREEEIWTFCERIAKAYEVPKESKMNIWYKVY 264  Plasmodium kn...
4JLE_A         89 FEMQGYALKQEKFLL-EYAFLSL--NGKLc-ERKKFKEVLEYVKREWIEFRKSMFDVW 142  Plasmodium falciparum 3D7
Q7RNN0        896 YSLVNKFVKHEKEDV-SEFKELL--KSSTn-VSFNFVEFIKNKKEAWRELQSEIKDTW 949  Plasmodium yoelii yoelii
EDL42944      643 YNMTDELIKKERGDF-QDFYAFV--SKGQc-QRWDFLYFANAKRKSWDELRDLMKSIW 696  malaria parasite P. vivax
Q8IAK9       1152 YMLTEEVVKRERTDN-LDFHQFL--RKGSc-EKREFLYFINSKRKGWADLTETMKNIW 1205 Plasmodium falciparum 3D7
XP_001612770  229 HILMSNLKKMHANDL-DHFANFL--KKESc-SIDEFKKYMADKIIRWQNFTSEKKKMW 282  malaria parasite P. vivax
Q8I3F2        160 NILQSNLTKMDNDDK-GNFDKFLesQPDPc-PTQEFVTFMDNKIKLWDEFMPKKKNdl 215  Plasmodium falciparum 3D7
Q8IHN7        169 HDLQCDFIKEHPNIH-SNFDVFI----RKiqSIDEFISYIKECIHSWNNFTNEKKlqy 221  Plasmodium falciparum 3D7
EDL42369      110 NKLGRDLIRLSDNDDdGGLKVFL--QEKKtcKTSDFTKFLNDRMKTWNAFIKEKKKva 165  malaria parasite P. vivax
XP_002257686  458 NKLNKVMDEFDLRDR-ADFNHFL--MQKKrhSAEDFERFVENRICLWNKITRE--NRY 510  Plasmodium knowlesi strain H
XP_002261677  265 YNMKEETIKTEKHQF-NKIYPFM--DKGLc-EDEVFIKFLFDELDVWKRKMKSIERKW 318  Plasmodium knowlesi strain H
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