Conserved Protein Domain Family
RE_HpaII

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pfam09561: RE_HpaII 
HpaII restriction endonuclease
This family includes the HpaII (recognizes and cleaves C^CGG) restriction endonuclease.
Statistics
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PSSM-Id: 401485
View PSSM: pfam09561
Aligned: 21 rows
Threshold Bit Score: 341.162
Threshold Setting Gi: 342329932
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX60762                 2 GEIYAFFRLLADGSVYMGTPQVQKDMNRCWPVAL-VQREEHDGTRRYYIEEDe-iRMVSGEVDRSgqfvpkeeaesVTFP 79  Bacte...
CCG52267                10 SEVYTLLKVISDKQLFAGDSNLNKIETLIFPIIK-VLRDETNGTFEFSYDND---LVIVKNGEEE-----------IRIS 74  Flavo...
CDA44980                11 SEIYTLFKLLGEGKVHAGDADMNKLE-LYYPILN-VIREESKK-YEYKPNVDqhiVVIDEDGNEF-----------ARIS 76  Prevo...
SLUandSVAtrep:TPE_0407  14 SEIYVLLRLLADGKIYAADSELNKLKDVYFPIIK-IIREENKGEIKEYSTGEivaIYINGSKVK-------------ELP 79  Trepo...
ASGPB:SGRA_2429         10 SEIYTLLKLISDGVLPQGDAHLVATD--FEYIVEaVYRSEKDGLKEYHINSDqksVLLIDGEEQ------------VEIP 75  Sapro...
BAK56574                10 NEFYALLYLLENNNISIVDSDLCVIDSAIFFINKlVTQGETS--LTYQKVDDeiiIFKNTQKIGV-------------VS 74  Candi...
jgi:Cyast_0446         309 TERYSFFKIINDQRINLADKTLQKNNS-YFNVTK-ISTLNLD--ENIILVDKdsiIVENKITKSKk---------eINIS 375 Cyano...
Q30PG8                 311 SELFAFIKILLEQKLLLSDKELNPTGD-FFKINK-ITTENLD--LEFIPVSDfkiKSIHTKTKEEa---------eIDIS 377 Sulfu...
jgi:Ftrac_0428          10 SELYVFFQLLSEGKLYSADEKLERNGN-FVEVQS-IKRNDFGKPKDYKIETSgnvNIVDSETGNIl----------RAIP 77  Mariv...
CDC82814                12 SEIYAFLRLLEIKKLYAADAELNKKDDMFYNIIS-IIRTEPIGTLEFRINKAddtVSVIKTDTEDv---------lLTLP 81  Clost...
CCX60762                80 RADFGEAADYVLDIL--KHS-SGEEVEVpDGLEGFLDAV-RIYDLEAKT-DDRTDFKIAFWQKD---APLTGFCVRCRLS 151 Bacte...
CCG52267                75 VLEFQKQAHFLLTKL--KEK-TNATFSI-PEIESFINSF-DSHSLKAKS-SVKSDIRIVIHDLRtgtNPELGFSIKSQLG 148 Flavo...
CDA44980                77 MNKFLEESSKLLTEI--KAA-NDPAFEI-PATESFMTEI-GCSKLKAPS-KDKADIHIVIHDLRtnmTPLLGFSIKSQLG 150 Prevo...
SLUandSVAtrep:TPE_0407  80 ATEFEMQSELLLNEI--NSKiSKGAFSV-EKTQNFMDKI-LCYKLSAPA-TDKSDITIKIIDINtgySPTVGFSIKSELG 154 Trepo...
ASGPB:SGRA_2429         76 LEEFEAIKTVVLDGI--RQA-PKGTFLI-EEAIPFLSTI-HCLSLKAKS-SSKKDIEVLIYDYRvarSSKLGFSIKSQLG 149 Sapro...
BAK56574                75 LDAVIKAKEFLLKTLinKKPlNGGSIKL-PSLNEFIENFtDGYSIKGKA-KSKADLGANVKDNKickDVNITYSLKSQFG 152 Candi...
jgi:Cyast_0446         376 ELINQNVLDNLVNQI--KD--NKGTFEI-NEMIAIQNKL-GISIIKGGQsNQKSDVILDI-NKDhffKVNEGFGIKSYLG 448 Cyano...
Q30PG8                 378 SIITDETLTNILNQI--KA--GSGTFEI-NDFEIIQTAL-GFSIVKGGNsSQKADIVLDI-EHNtfvKENEGFGIKSYLG 450 Sulfu...
jgi:Ftrac_0428          78 RAEIVDITRNLIREL--KQG-KGKAFGVsSSLEANINSF-MIEKVSESY-GLKGDINLYIYDPVnsiLTDQKFSIKSLLG 152 Mariv...
CDC82814                82 RDEFKTAADNLYNEI--INA-NKSSFES-QDTEEFLEQL-NIGVLKAKS-TDKADIRIKIHDINtgyETVQGFSIKSRLG 155 Clost...
CCX60762               152 PMNPLLDGGRTANLKLEQTGVkf-aVPTVNKVNALP--ESPNE-VAERMLMIERLGGVLKYSDVADRVFRCNLLMIDLHF 227 Bacte...
CCG52267               149 GASTLLNAGKTTNFIFKIQNL----TLTQNQISEINaiETRSK-IKDRIEKISEFGGSLEFQKTESSIFGNNLILIDSAL 223 Flavo...
CDA44980               151 SASTLLNAGTTTNITYKVIGTe----lSDEDIEEVNsiKGHLP----RMQAILDKGCNLKYSDIEHTIFKNNLLFLDSCM 222 Prevo...
SLUandSVAtrep:TPE_0407 155 SSPTLLNAGKTTNFIYKIIHGypdlVREANEIYIVSagKNHTD-VRGRINKIIDENGQLKYWKMNNQTFRDNLVLIDSNM 233 Trepo...
ASGPB:SGRA_2429        150 NPSTLLNASKATNFQFWL--------PQEVNAESINkiSTSSK-IKKRIEAIYEEVGQLVFTTIQNQTFANNLCLIDSAL 220 Sapro...
BAK56574               153 SPATLLNASKHTNFMHKVQGF------DKDKMQEVNriKTKKK-LLDRIYKIKELEGKIEFYKIVSNTLERNIRLIDSSM 225 Candi...
jgi:Cyast_0446         449 NKPTLLNASGNTNFIFRVNNL------SSYSLDEINniK---K-LKDRINKIINLGGIFSFYKIEKETMAYNLRIIDSMM 518 Cyano...
Q30PG8                 451 SKPTLLNASGNTNFMFEIDGL------DNSKISEINqiSTATK-LRDRIVAINKNGGTFRYLKAEKDTMNYNLKMVDNVL 523 Sulfu...
jgi:Ftrac_0428         153 SNPTAFNANPTTNIIYEILTKdg-kPLEENEIIEINeiDTRHK-YIDRVRFILD-NYSIHYRDYQGEVFKLNLQLIDSSL 229 Mariv...
CDC82814               156 SPSTLVNAGKTTNFVFEVIG--------NINDDVMNgfNTCSKkFKDRFDFLSGYDCDIEYCSMDNDIFESNLQLIDGDL 227 Clost...
CCX60762               228 PRMLAEMVRLMHL--EGITRVSELTERIKE-LNPLKIKdeLIQKHGFYEYKMKQFLLALALGMRPAKIFRGTDSAVEGML 304 Bacte...
CCG52267               224 PKIIAESLKLFYT--STFSTTIELTNQIST-TNPLDYN--LETNHPFYSYKIKRFLTDIALGMMPSKVWTGELDATGGYL 298 Flavo...
CDA44980               223 PQFVADCLLINSLp-SSKSSIKECVAEIAK-RNPFNFN--GKNIEAFYAHKMKVLLLDAALGMTPAKEWTGRYDANGGYL 298 Prevo...
SLUandSVAtrep:TPE_0407 234 DKIIAETLLYFYR--DGISNCDEMVEKLER-ENPMNYG--NVNA---YRYKFKKFLTAVALGMKPATVWDGVDEATGGYI 305 Trepo...
ASGPB:SGRA_2429        221 PQIIAALLLIYYSgrAKSSKITDLVEQLRI-ENPLGFP--EIEGQHFYEYKIKRFLTDVALGMTPNTVWDGRFDAGGGYI 297 Sapro...
BAK56574               226 DKLLANALLYSYV--ENEKDLQKAFLKSNH-----------GNDEVFLRKKLIDFLYGICFGFFPSEEWDGKYSVNGGIM 292 Candi...
jgi:Cyast_0446         519 PNLLAEMLLEFFV--HRNNLISE--NLLTIyQKQLAQT--MIDDLPSLTIKLKRFLVGVLLGFFAETKWDGKY-SSNGTI 591 Cyano...
Q30PG8                 524 PEIIGYLLMAFYG--NRISNLSDIVNYLCDyTDILTHL--DIDDKAMLINKLKKFLVDILLGFFAGEKWNGSY-ASNGTI 598 Sulfu...
jgi:Ftrac_0428         230 PEIIASAVLNKYA--FGITKFNEVIEKLND-ANPCNYN--LKHGHSFYEYRLINFMVESSLGMTSATVWSGEYDVIGGII 304 Mariv...
CDC82814               228 PKICAYMLKEYYS--SGVNTVTNSLESLNV-NNPIGYN--LSKGHPFYEYKFKKFLAECALGMLPSKVWDGTADATGGYI 302 Clost...
CCX60762               305 LVDGQGEVLC----YHQSCRQDFAEFLYQNTRFEKGALEKDKYGFLERE-NGSWYFKLNVKIGL 363 Bacteroides sp. CAG:598
CCG52267               299 VVKENGEVLC----YHIYNRNEFEDYLYSNTKLETASSTRHEFGKVYEE-NGQLYFKLNLQIRF 357 Flavobacterium indicu...
CDA44980               299 VVRKDGEIVC----YHFYNRNDVEDYLYNNTRFERASRSRYGFGYVYREkDGCIYIKLNLQIRF 358 Prevotella sp. CAG:5226
SLUandSVAtrep:TPE_0407 306 VVTKEGYVLA----YHIYNRNYFEEYLLKNTKYETASTSRHDFGEIYSE-NGKDFINLNLQVRF 364 Treponema pedis str. ...
ASGPB:SGRA_2429        298 VVRNDGELVC----YHIYDRNQFEDYLFHNTKLDTPSSSRHGFGLIYRE-GGENYFNLNIQIRF 356 Saprospira grandis st...
BAK56574               293 VTKNSGEVVLldkiYH---NEILENYLYYKSKFDSPSTSRYHMLEIFED-SGDFFFTLNLQIRs 352 Candidatus Arthromitu...
jgi:Cyast_0446         592 VVKENGEQLA----FHIIDIVSLEDYLFENIVFDTPSTTRHRYGKLILEnDGCLYFKLNLQLRF 651 Cyanobacterium stanie...
Q30PG8                 599 VVKENGDLIT----FHIINMENLKNYLFENIKLDTPSTSRHKFGTIIQD-KTKNYFKLNLQLRF 657 Sulfurimonas denitrif...
jgi:Ftrac_0428         305 IVKGNEEVVS----YHLIDFNKFKKYLLDNCRLDNPSGSKMGYGTAYIE-EGKSYIKLNFQVKv 363 Marivirga tractuosa D...
CDC82814               303 IVREDGEVLC----YHLFNRNEFETYLINNTKFETASTSRHEFGSIYKE-NGKFYIKLNLQVRF 361 Clostridium sp. CAG:964
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