Conserved Protein Domain Family
RNA_lig_T4_1

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pfam09511: RNA_lig_T4_1 
RNA ligase
Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defense to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i
Statistics
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PSSM-Id: 401458
View PSSM: pfam09511
Aligned: 129 rows
Threshold Bit Score: 82.284
Threshold Setting Gi: 156566901
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KIA3        188 LARGLFTEEVLEgdpvppleacsgqigsdpdapReRIVLRGYDKFFN-------------TGEVSWTEWDAMKQHT---- 250  Cryptococcus ...
Q54HU9         79 ECRGLIFNEATS-----------------------EIVCRKLHKFFN-------------INEQQETKEELIKLD----- 117  Dictyostelium...
XP_003291449   79 ECRGIIFEEKTG-----------------------KIVCRKLHKFFN-------------INELPETNQDDILLD----- 117  Dictyostelium...
EFA84232       75 ECRGIIFDQSNG-----------------------KLLSRKFHKFFN-------------INELRETKAELIDLN----- 113  Heterostelium...
Q54MC4         79 ECRGLIFDLKTE-----------------------KLLCRKLHKFFN-------------INEFKEVKAEFIDLN----- 117  Dictyostelium...
EGC35263       76 ECRGLIFCKKTE-----------------------KLLVRKLHKFFN-------------INEYRECKADLVKLD----- 114  Dictyostelium...
XP_004361387   92 ECRGIIFDESNQ-----------------------QLICRKLHKFFN-------------INEYQECRAENVSLK----- 130  Cavenderia fa...
EFC40808       55 ECRGLVLELNS----------------------W-KIVARGMTRFFNqhhsyssspnirgLNDDRELVFLEQDQSPslek 111  Naegleria gru...
Q8B9G9         51 ECRGLILNSRT----------------------Y-AVVSRSFDRFFN-------------FQELLQNIGGEDAHHKlf-- 92   Rachiplusia o...
EFC41136       98 ACRGVIVDLEE----------------------M-RIVHMPFSKFFN-------------FNEPMAKRDSEIISEH---- 137  Naegleria gru...
Q5KIA3        251 -----QGPYYLTLKSNGCLILIS-ALSPTHL---IVASKHSLgtttaaegvdlsgseklidkekpaqkcgdsalgpeisq 321  Cryptococcus ...
Q54HU9        118 ------ENFIVLEKLDGSLIAPI--LINGKA---AWGSKSGI-------------------------------------- 148  Dictyostelium...
XP_003291449  118 ------EEFILLEKLDGSLIAPI--NIDGSP---AWGSKAGI-------------------------------------- 148  Dictyostelium...
EFA84232      114 ------QPFILTEKVDGSLIAPI--LVGGSV---LWGSKQGA-------------------------------------- 144  Heterostelium...
Q54MC4        118 ------EPYILMDKIDGSLIAPM--LNKGQV---YWGSKQGI-------------------------------------- 148  Dictyostelium...
EGC35263      115 ------GEYILMDKIDGSLISPMlIDNEGSVmgiYWGSKQGI-------------------------------------- 150  Dictyostelium...
XP_004361387  131 ------EPFTLTEKIDGSLIAPF--IVNGSI---SWGSKQGM-------------------------------------- 161  Cavenderia fa...
EFC40808      112 sklfdYSNFSLETKEDGTFLLMF--CYEGEW---MIATRHNF-------------------------------------- 148  Naegleria gru...
Q8B9G9         93 ---qsKENFKFYEKIDGSLIKIY--KYNGEW---HASTRGSA-------------------------------------- 126  Rachiplusia o...
EFC41136      138 -----FDHVKIYEKFDGSIVNFY--FFDGEW---RVASSSTP-------------------------------------- 169  Naegleria gru...
Q5KIA3        322 irtipsfpptvgsldkhfkdltleqsqanqslsknalkkaekaalkyaqkvinegksedsaqitaaeekkeikeneeAQQ 401  Cryptococcus ...
Q54HU9            --------------------------------------------------------------------------------      Dictyostelium...
XP_003291449      --------------------------------------------------------------------------------      Dictyostelium...
EFA84232          --------------------------------------------------------------------------------      Heterostelium...
Q54MC4            --------------------------------------------------------------------------------      Dictyostelium...
EGC35263          --------------------------------------------------------------------------------      Dictyostelium...
XP_004361387      --------------------------------------------------------------------------------      Cavenderia fa...
EFC40808      149 -----------------------------------------------------------------------------CED 151  Naegleria gru...
Q8B9G9        127 -----------------------------------------------------------------------------FAE 129  Rachiplusia o...
EFC41136      170 ------------------------------------------------------------------------------DG 171  Naegleria gru...
Q5KIA3        402 HAEVGRRWLKR---T---LESSGKTE-------------EELAQK-------LWEKNLTAVLELCDDsfEEHVIATPEHW 455  Cryptococcus ...
Q54HU9        149 -TDLTI-KVEKhiqLkl--kDNNIRY-------------DDFALE-------WMLKGYTPLFEWCSE--SNQIVLYY-AI 201  Dictyostelium...
XP_003291449  149 -TDLTT-RIEGhikKk---lEEETKY-------------DEFAKY-------CFEKGYTPLFEWCSV--LNQIVLFY-PV 200  Dictyostelium...
EFA84232      145 STDLAD-KIEDfiaRn----QEFYSY-------------NQFSLE-------WLNKDYTPMFEYSSK--SQQIILFY-GE 196  Heterostelium...
Q54MC4        149 -SDLGT-MLNDyvnRie--aIGLVKY-------------NDFSMK-------WIQLGYTPLFEYSSS--KQQIILYY-GE 201  Dictyostelium...
EGC35263      151 -SDLGT-MLNDfivRvesNQSNQIKY-------------NEFSKK-------WLENGYSPLFEFSSP--KQPIIIHY-KE 205  Dictyostelium...
XP_004361387  162 -TAFGK-RIDDfvnN-----NDSIRY-------------NDFAQY-------WLDRGYTPVFEYSSD--KQQIILFY-QE 211  Cavenderia fa...
EFC40808      152 YLAIGS--------------ETQKTYrelfveicggvelNEIGKD--------LDPSLTYCLEMCSS--QNEIVQIY-QN 206  Naegleria gru...
Q8B9G9        130 NLCVSDVTFKRlvlQalqLDEAHNQF-------------QALCNE-------YLDCASTHMFELTSK--HNRIVTVYDEQ 187  Rachiplusia o...
EFC41136      172 SAKMGFYSVSKdkeEnekHRQESKTFvfad------lvwNAFNDLgfkipptEFEGKYSFTFELLTQ--KHPLVVQHPEQ 243  Naegleria gru...
Q5KIA3        456 TGLHLHGLNSNTP---------HFSTSS--PSDVATFAKEFG----FIQTKYIQLETLE--------------------- 499  Cryptococcus ...
Q54HU9        202 DNLNLIAMRNMKTg--------EYLTHD----EMVKITAPFNv----pVVTCVDLKSHThfsklyselngadksitttse 265  Dictyostelium...
XP_003291449  201 DKLHLIAMRNMLTg--------DYLTHS----KMVEAAKPFNv----pVVECVDIKNHPqfvelykelss----ngadhd 260  Dictyostelium...
EFA84232      197 EKLSLIGIRDNVTg--------AYISYE----EMSKSATGFNv----pVIKRIDIANHPels------------------ 242  Heterostelium...
Q54MC4        202 ERLRCLALRNNHTg--------EYLKWK----ELQETCTAFNi----pMVDLIDTTSDQslfk----------------- 248  Dictyostelium...
EGC35263      206 EVLRLIAMRNIHTg--------EYLRWV----DLKKAADEFNi----pMVDLIDMKKDSkfe------------------ 251  Dictyostelium...
XP_004361387  212 ERMRLLAIRDRTTg--------NYLQYD----EILKSGQEYGv----pVVERIKLESLLdpdld---------------- 259  Cavenderia fa...
EFC40808      207 PVIYLLTIVETQSg--------KELSRDqvDKICLKLRKRAElknwKRPKRFENFSSLEqa------------------- 259  Naegleria gru...
Q8B9G9        188 PTLWYLASRNNETgdyfycsnlPFCKYPkcYEFT---------------------------------------------- 221  Rachiplusia o...
EFC41136      244 DNLILHGVR-------------CLETFS--EKSIEPFAQQFNwkyaTCVKEKFGFKSLE--------------------- 287  Naegleria gru...
Q5KIA3        500 -----QVKSFTA--DLAQSGTwegeMIEGFVVRC-TVkngqdgmsqgappyranspfffkIKFEEPYL 559  Cryptococcus neoformans
Q54HU9        266 efintGASKLLK--IVLGLEN-----CEGYILKF-DSgk--------------------tYKMKSNWY 305  Dictyostelium discoideum AX4
XP_003291449  261 nlvktGAKRILE--LVQKIPQ-----VEGYILKF-DSgr--------------------tYKLKTNWY 300  Dictyostelium purpureum
EFA84232      243 --likTTTDLVH--AAKRMRN-----VEGFVLKLeNTgh--------------------hYKVKTEWY 281  Heterostelium album PN500
Q54MC4        249 --sckSTIELVE--LVKQMKL-----IEGCVLKFeNSgk--------------------mYKIKTEWY 287  Dictyostelium discoideum AX4
EGC35263      252 --svkKTEDLVE--VVKGLKY-----IEGCVLKFeDTgl--------------------mYKIKTSQY 290  Dictyostelium purpureum
XP_004361387  260 -pnsiTTNELVN--IVKKMKN-----VEGFVLRV-NDgr--------------------mYKIKSEWY 298  Cavenderia fasciculata
EFC40808      260 ---lkHLDTFISthENVEARL----RIEGFIMRDtNNq---------------------rLKLKNPFY 299  Naegleria gruberi
Q8B9G9        222 -----SVQECVE--HAAQLKN----LEEGFVVYDkNNap--------------------lCKIKSDVY 258  Rachiplusia ou MNPV
EFC41136      288 -----DVSKMAD--ERNAYEH------EGFVVCYeTPdnngse-----------svdfirVKIKNSEY 331  Naegleria gruberi
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