Conserved Protein Domain Family
Dimeth_Pyl
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pfam09505: Dimeth_Pyl 
Dimethylamine methyltransferase (Dimeth_PyL)
This family consists of dimethylamine methyltransferases from the genus Methanosarcina. It is found in three nearly identical copies in each of Methanosarcina acetivorans, Methanosarcina barkeri, and Methanosarcina mazei. It is one of a suite of three non-homologous enzymes with a critical UAG-encoded pyrrolysine residue in these species (along with trimethylamine methyltransferase and monomethylamine methyltransferase). It demethylates dimethylamine, leaving monomethylamine, and methylates the prosthetic group of the small corrinoid protein MtbC. The methyl group is then transferred by methylcorrinoid:coenzyme M methyltransferase to coenzyme M. Note that the pyrrolysine residue is variously translated as K or X, or as a stop codon that truncates the sequence.
Links
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Statistics
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PSSM-Id: 370535
Aligned: 7 rows
Threshold Bit Score: 776.642
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AGY50178             8 RGDGKRLYLSRQQILDDINEGIADAADIASVPNLTSDDIDFLLEILIDSNRTVGVEVGKEVVLTYDIGQIDLEGDTGNSG 87 
licsiro:TALC_00301   1 MGDGRTVYMTRENVLEDIRKGMADAADAAGVPDLNENEIEQMADVICSDERLVSVPRGHEVVMSEDGGPYKMMIDSGSSG 80 
AGI85870            10 MGDGKRVTMTKEQIMADLQAGTADAADMGSIPALTADDLERLADIICDKNRIVAVEPGNEVVLTYDIGQLDFTGDNGNSG 89 
jgi:Acear_1273       9 LGDGSTIEMTEDEIRADIERGIEDAVDRAEVDSLPEEEIEKLTDIYTRPSKFVSVETGNELVLTFDEGSVKLKR------ 82 
jgi:Metev_1439       9 MGDSTTEYHSKDRIMEDIEAGTNDAAELGGIPALSDDDKEKIADILMSPQKMVSVDAGNEVPVTHDIGTLRIDGDQGNSG 88 
Q8TS72               9 MGDGKRIFLTKEKIREELEAGAANAADLGEIPALSGDEIDRLAEILMMPGKAVSVEQGMEVPVTHDIGTIRLDGDQGNSG 88  Methanosa...
jgi:Mzhil_0605       9 MGDGKRVYHSKNQIMDDLEAGSADAADLGEISALSGDELEKLAEIIMTKSRMVGVEPGKEVPVTHDIGTLRIDGDQGNSG 88 

AGY50178            88 LGIPISRLTGALTHERAMGADTFELAHADYSIKPVKPIIANEMQAMETAQNNLVIPYFYGAMPNMGLYYSPDGPYGNPAD 167
licsiro:TALC_00301  81 NGIEISRLQAILAHERTLGMDSFQLAHIDYSIKAVKPIIGYEAQAMEQINMLSTVPLLYGAMPNMGLYYAPDGPFGNPAD 160
AGI85870            90 NGVDMGRLEAALIHERALGADTFELAHSDYSIKPVKPVIAMEMQTMEEIQQEIVAPYFYGAMPNMGLYYAPDGPYGNPAD 169
jgi:Acear_1273      83 LAVSIGRIPDLQIYERVFCSDTAELAHIDYSFKPVKPIVAEEQIEMEQALLSTVLPLYYGAMPNLSLYSQPDGAFPNPAE 162
jgi:Metev_1439      89 TGIPASRLTGVMTHERAFGTDTMELGHIDYSFKPVKPVVSQECQTMEVCQQNMTVPLMYGAMPNMGLYYQPDGPFKNPSD 168
Q8TS72              89 VGIPSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGD 168 Methanosa...
jgi:Mzhil_0605      89 VGIPSSRMIGCMMHERAFGADTMELGHIDYSFKPVKPVIAQECQAMEVCQQNMIVPLLYGAMPNMGLYYTPDGPFENPGD 168

AGY50178           168 LMREFKIQEARESCEAAVDHLARDIHFVSTKIMSAGADGFDFDTTASAGDGDFVATLRGVEMLRKECPQAYINLGMSGEL 247
licsiro:TALC_00301 161 LMREFKMEEAMDQAEKAAAQIAADIDYVFSGMMAAGSEGWNFDTTASAGDADFVGTLNGITEVRKKFPNAYIEMGMAAEN 240
AGI85870           170 LMREFKIDESMQQSELAAEHMARDIEYVGNKIISAGADGFDFDTMASAGDADFVGGLKGVEALRKANPLAYINTGMAGES 249
jgi:Acear_1273     163 LLPKGKVKEAQEAYEGMMEHAIKDMVFVGSKMYEAGADGINFDTTGSAGEPDFLATLKATEELKEKYPNISIEMGMAGEF 242
jgi:Metev_1439     169 LMREFKLQEAKKEIEGAADELTNDMVWTVDKLYKSAADGVNFDTIAAAGDGDFYATLNAIEALRKRFPNMYIEAGMASES 248
Q8TS72             169 LMKAFKIQEAWESMEHAADHLTRDTVWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAVEALRKEFPAMHIEVGMAGEM 248 Methanosa...
jgi:Mzhil_0605     169 LMKAFKIAEAQESIEKSADHLTRDMIWIIQHMMKSSSDGVNFDTTGAAGDGDMFATLHAVEALRKEFPEMYIELGMAGEC 248

AGY50178           248 VLGIHGELEYDGQIVAGLCPHQQVKLAAKAGASVFGPVVNTNTGKSLAWNLARALTFIKECVKVSPIPCHANMGMGVGGI 327
licsiro:TALC_00301 241 VLGIHGSIEYDGTPVAGLYPHQQVKLAEKAGVNIFGPVVNTNTSRSFAWNIARAVTMVKECEKVSNIPCHVNMGMGVGGI 320
AGI85870           250 VMGIHGGIEFHGKTVAGLFPHQQVKMCEEAGANVFGAVCNTNTSKSLAWNMARAVTFVKECVKQASIPVHCDLGMGVGGI 329
jgi:Acear_1273     243 VLGMHGDLEYNGVGLAGLYPHEQVKLAEEAGVDVFGPVVNINSSETIPWNIGRTVTMMKACAEAADIPVHANVGMGVGGV 322
jgi:Metev_1439     249 ILGMHGEFEYDGTTLAGLWPHEQAPLLGKAGANLFGPVCNTSTSHSTSWNLARAVTFVKSAVDKSPIPCHVNMGMGVGGI 328
Q8TS72             249 VLGMHGNLQYEGVTLAGLWPHQQASLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVDMGMGVGGI 328 Methanosa...
jgi:Mzhil_0605     249 VLGMHGGLEYDGKTLAGLWPHQQAPLVTKAGANVFGPVVNTNTSMSFSWNLARAVTFIKAAVEASDIPCHVDMGMGVGGI 328

AGY50178           328 PMTETPSLDAMTRCSKAMVEIAGVDGIOVGVGDPAGMALPHYVSSGMGGIRTAGDLVARMEYSKSMKISEAKEYVAKKLG 407
licsiro:TALC_00301 321 PMSECPPLDAVSRANKLMVEIAHVDGIOAGAGDPLGMSNAHVAASGMGGVRTAGDLVARMEFSKNMKLAKAKEYVAKKLG 400
AGI85870           330 PMFETPPIDAVTRASKAMVEIAKCDGVOIGVGDPVGMDMAHMLASGMGGIRTAGDLVARMEYAKNMKVDKAKEYVAKKLG 409
jgi:Acear_1273     323 PIVETPPADSLSRASAALAEIGKQDGLOVGVGDPNGMVISHALASGMGGVRTAGDLVARMQMSENMRLDEAKEYVADKLG 402
jgi:Metev_1439     329 PMFETPPVDAVTRCSKAMVEVAGVDGIOVGVGDPVGMPIAHVSASGMTGMRAGGDLVARMQLSKNMRINEAKDYVSKKLG 408
Q8TS72             329 PMLETPPIDAVTRASKAMVEVAGVDGIOIGVGDPLGMPISHIMASGMTGIRAAGDLVARMQFSKNMRIKEAKKYVAKKLD 408 Methanosa...
jgi:Mzhil_0605     329 PMLETPPIDAVSRASKAMVEVAGVDGIOIGVGDPMGMPISHIMTSGMSGIRAAGDLVARMQFSKNMRIGEAKKYVADKLG 408

AGY50178           408 VSSIDLADEYVMKDLREELGLGVVTAIPGVPKGIAAKMNIERLLDTKINCCEHFRN 463
licsiro:TALC_00301 401 ISEIEIADETVMRDLRYDLGLGNVTSIPGAAKGMEAKLNIEKVLGITINSCEKFRG 456
AGI85870           410 LSTLDIADEHVMRDLREELKIGVVTGLPGAPRGIAAKMNIEKLLDIKINSCEKFRQ 465
jgi:Acear_1273     403 VEVGELTDPVIMDEVRNELNIGRVQPEAGEAKGVEAKFNISELLDIRINSVEKFKN 458
jgi:Metev_1439     409 VEPMDLSDEYVMRDLREELGIGVLTSVEGAPKGISAKMNIEELLDIKINSCEKFRN 464
Q8TS72             409 VDVMDLADEHVMRELREELDIGVITSVPGAAKGIAAKMNIEKLLDVRINSCELFRK 464 Methanosarcina acetivorans C2A
jgi:Mzhil_0605     409 VTPLDLSDEFAMREIREDLGIGVITSVTGAPKGIAAKMNIEKALDIKINSCEKFRN 464
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