Conserved Protein Domain Family
Med12

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pfam09497: Med12 
Transcription mediator complex subunit Med12
Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.
Statistics
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PSSM-Id: 401449
View PSSM: pfam09497
Aligned: 77 rows
Threshold Bit Score: 67.9314
Threshold Setting Gi: 74964629
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC95724      140 YKPPSRVTLNDTKLANYVKDLADPSVPLTrlsRSVPHGFRGEKLFEMLWaggalpssgaaaaaaaatsnyfhsrtpaass 219  Pseudozyma hu...
EFA81264      168 RAVPEQNAWMQSARDSWVARLAG-NEPLCklaQSVPHGHKGDSLIKMLL------------------------------- 215  Heterostelium...
EGG20242      206 RHVPEQSAYSISLREAWVNKLKETNEPLQklaAAVPHGYKSDQLIKMFL------------------------------- 254  Cavenderia fa...
Q54U49        448 RPVPEQKAWSANHRESWVLKLAG-NEPLQklaSSVPHGYKGETLLKMFL------------------------------- 495  Dictyostelium...
XP_001754008   26 GVFPDHRTCGDDFRKKWIEDLSQ-RKRLRalaEHVPHGYQRRTIFEALI------------------------------- 73   Physcomitrell...
EFJ05540      164 GQFPERHTYGEDYRKKWIEDLSQ-RKRLSllaEHVPHGFHRRTLFEALV------------------------------- 211  Selaginella m...
XP_002274479  157 CVFPEQRPCGEDFRKKWIEGLSQHHKRLRslaDHVPHGFRKKNLFEVLI------------------------------- 205  wine grape
XP_015697431  162 GMYPEQMHSNEDTRRKWIEALSQPNRRLLslaEHIPRGFRRKSLFNYLI------------------------------- 210  malo sina
RQL82691      146 G-FPEQKSCGEETKKKWIESLSQQHKRLRslaDNIP-GYRRKTLFEVLI------------------------------- 192  Brassica cretica
XP_006682867  310 FTISRRTGTSSKTYDNWIDDLFG-NIPFSelsKSVPFGLKLDKLLESLQ------------------------------- 357  Batrachochytr...
GAC95724      220 astpsanasvaatpapRKSVDISRAVWFIR 249  Pseudozyma hubeiensis SY62
EFA81264      216 ----------------ENQIPLIRATWYTK 229  Heterostelium album PN500
EGG20242      255 ----------------EFHIPVLRATWYTK 268  Cavenderia fasciculata
Q54U49        496 ----------------DNQVPLIRATWYTK 509  Dictyostelium discoideum
XP_001754008   74 ----------------KHDVPLLRATWFIK 87   Physcomitrella patens
EFJ05540      212 ----------------KQNVPFLRATWFIK 225  Selaginella moellendorffii
XP_002274479  206 ----------------RNNVPLLRATWFIK 219  wine grape
XP_015697431  211 ----------------RYNVPLLRASWLVK 224  malo sina
RQL82691      193 ----------------RNNVPLLRATWFIK 206  Brassica cretica
XP_006682867  358 ----------------QKQVSLVRATWAIK 371  Batrachochytrium dendrobatidis JAM81
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