Conserved Protein Domain Family
CENP-O

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pfam09496: CENP-O 
Cenp-O kinetochore centromere component
This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere. It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.
Statistics
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PSSM-Id: 401448
View PSSM: pfam09496
Aligned: 60 rows
Threshold Bit Score: 108.862
Threshold Setting Gi: 757945398
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7SFQ0        93 ITTFRVqdpdpNA--V---DGGA--VLGLRIEVFAR-GR-FMRPYYVLMNRPW---SEGTKngkagnsssssssskekek 160 Neurospora crassa
EGW30421     138 ITAFPI-----NQyvF----NADdeLMGIRFDRYASsTNtFQPPHYVILRQINiysEKEQEltie--------------- 193 Spathaspora pas...
EMG50305     133 VTAFPI-----NQflF---DGSNmsIVGLRFDIFSNtTKtFVTPHYCILERLS---LNKHGstl---------------- 185 Candida maltosa...
XP_002548613 125 ITSFPI-----NQylF---LNNQesILGLRFEIFSNfNHsYNLPYYCILKKTT---TIKDEtsi---------------- 177 Candida tropica...
Q6BQI6       140 VTSFPL-----NPflF----DENdeIMGLRFDVFSHyKRkFITPHYVILRKMK---NTEKGlet---------------- 191 Debaryomyces ha...
XP_004197149 152 VTAFPL-----NRlpF-----ENseLIGIRFDMFSHnSQsFLKPHYAILKKVQ---VESKEsdv---------------- 202 Pichia farinosa...
XP_002324956 130 kiTYRV-----GNkvIcclEGAR---IGIQYETTFA-GD-PCELYHLVLESKS---FLEK-------------------- 176 black cottonwood
CBI20764     119 kTTYKV-----GNkvIcclEGAR---IGIQYETSFA-GE-PCELYHCVLESKS---FLEK-------------------- 165 wine grape
XP_006358621 106 kiTYKV-----GNkvIcclDGAR---IGIQYDTSFA-GE-SCDLYHCVLESKS---FLEK-------------------- 152 potato
XP_009131177 104 rIAYRV-----GNkvIyclEGAR---IGIQYGTSFA-GE-TYEIYHCVLESKS---FLEK-------------------- 150 field mustard
Q7SFQ0       161 nrsssrkattggggryanwLRVHRHTVPPCIPISGLAARYLpappspspssssssssrrrpieeeeEEEEQGGVREQNLV 240 Neurospora crassa
EGW30421     194 ----------------rktWSVYKHTLPNYVPLSDYQKLLD--------------------------------ESKESII 225 Spathaspora pas...
EMG50305     186 -----------------yrWIIYKHTLPVFLQLDKYEGYLNe-----------------------tDDNP------RNLW 219 Candida maltosa...
XP_002548613 178 -----------------dnWMIYKHTLPSFINLDDLSIILN----------------------------RFGFTDQENLT 212 Candida tropica...
Q6BQI6       192 ----------------tmkWEVYRHTLPVYLPLSEYSECLHe-----------------------dEEVA--------FS 224 Debaryomyces ha...
XP_004197149 203 ----------------qmrWSVYRHTLPAYIDVEYASRKLEa-----------------------eDEEI-------ALW 236 Pichia farinosa...
XP_002324956 177 -------------------MTVLEHTIPFFLPLREAENDLL----------------------------------SSNAM 203 black cottonwood
CBI20764     166 -------------------MTVIEHTVPFFLPIREAENDLL----------------------------------SSNAM 192 wine grape
XP_006358621 153 -------------------MTVLEHTVPFFLPIREAENEFL----------------------------------SSNAI 179 potato
XP_009131177 151 -------------------MNVLEHTIPFFLPLRDLENVLL----------------------------------SSNAK 177 field mustard
Q7SFQ0       241 KFARSLRRELVRYHHRLATITDLR----RAIMAEDqqteqqeekgpnKIQDVIPADAEAK----------------QIT- 299 Neurospora crassa
EGW30421     226 QFTRHVRDFLTKIQYKHDKLDQLLqlrrKQFDLPNd----------sPIISNIERDLSCE----------------RIQ- 278 Spathaspora pas...
EMG50305     220 KFVEVIYSDLTKFQYRLDKLNQLLkftkSQFGSLLe----------ePVFSKLDHDSQCQ----------------RIS- 272 Candida maltosa...
XP_002548613 213 KFSDCIYEILNKIQYKIDKFEKLMnfskNQFGLISe----------sPIFDKINYDLQCQ----------------RIT- 265 Candida tropica...
Q6BQI6       225 KFTQQIREHLIQIQYKHDKFDFLRnikyDHISKNRssq-------grVVIEKVEKDLQCQ----------------RIN- 280 Debaryomyces ha...
XP_004197149 237 EFATGIREGLLVVQYRHDKIDALLnlkfGHVDPSFpek-------elKVIRTLEKDLSCQ----------------RVV- 292 Pichia farinosa...
XP_002324956 204 RFIDYIGELLQAYVDRKEQVRLIK----ELYGNQIgelyh---slpyHIIEFVLDDFPCKvivslryadlvsvlptRVRv 276 black cottonwood
CBI20764     193 KFIDHVGELLQAYVDRREQVRLIK----ELYGNQIeelyh---slpyHMIEFALDDSDCKitvslryadllsvlptRIRv 265 wine grape
XP_006358621 180 RFIDHVGDLLQAYVDRREQVRLIK----ELYGNQIgelyh---slpyHMIEFVIEDFDSKvtvslryadlistlptGVSv 252 potato
XP_009131177 178 KFIDNVGDLLHAYVERREQVRLIK----ELYGNQIrelyh---slpyHMIEFAIDDCDCKvvvslrygnlmcelptKVRv 250 field mustard
Q7SFQ0       300 VEWADGQTG-------RLVMGD--DGEIVQVVALNgggggggqgnGSG-RDREVVRELVGNAKRVEDVVRRL 361 Neurospora crassa
EGW30421     279 ITFKSKNKLf-----lELLLST-------DTIEVCtfks---sisSSHkQQLRFCESILR-DCNISDIIKKt 334 Spathaspora passalidaru...
EMG50305     273 LLLNRPQKTe-----iELLCSA-------ETVDVVnfi----rftNAEqEHLQVCKAILE-NTKLTDLIKNF 327 Candida maltosa Xu316
XP_002548613 266 LSFNKLNL--------ELVCSE-------DTIQVAnfgtsgnnleDRLdNQLLMCKTILE-NCKISNLVKNF 321 Candida tropicalis MYA-...
Q6BQI6       281 ITLLNRVSNskraseiNLVCTN-------DEIKEVscii---sgvDSDdKIIIQCESLLK-NCDLKDLIKTF 341 Debaryomyces hansenii
XP_004197149 293 ISFSTRFHIssykldlELYCSD-------RAVESAsfl----hhdAKHnETILLCENLLN-NCDMNALIRTF 352 Pichia farinosa CBS 7064
XP_002324956 277 IAWPIDQFK-------KSEVMG------------AhpsprrlsyaEDAlKSMSLPEAYAEIVLRLPQVtqen 329 black cottonwood
CBI20764     266 LAWPMQPSK-------KIITSTgtIGRK------GnsvparlsyaEDAlRTMSLPEAYAEIVLNLPRVLQqn 324 wine grape
XP_006358621 253 LAWPMHQSK-------KS--SDkiAPHLKGNGVGShpiparltyaEDAlRTMSLPEAYAEIVLNLPQALqdm 315 potato
XP_009131177 251 LAWPMHQLK-------R-QCTSprLSKLA-----SqaipvrlsfaEDAlRIQSLPEAYAEIVVNMPQEIEqi 309 field mustard
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