Conserved Protein Domain Family
CbtB

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pfam09489: CbtB 
Probable cobalt transporter subunit (CbtB)
This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional transmembrane segments.
Statistics
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PSSM-Id: 401441
View PSSM: pfam09489
Aligned: 23 rows
Threshold Bit Score: 36.1681
Threshold Setting Gi: 81376210
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5Z2S3         10 RSTDSVATVLVTIGVVLLALLTLYLVGFDQGAVsrggmfLHELMHDGRHLLGVPCH 65  Nocardia farcinica
WP_015475371   13 TSIPLSKRISLAVGASLLGALLVYFAGFSHLEA------VHNAAHDTRHSAGFPCH 62  Pseudomonas
jgi:Psefu_4439 12 STLPLSQRILLAFGSCVLGAVLIFFAGFSHVEA------LHNAAHDTRHSAAFPCH 61  Pseudomonas fulva 12-X
Q605I2         40 SLPVHVGARAAAIAAFALGGLLVLMVGFSPLPA------VHDATHDTRHSAGFPCH 89  Methylococcus capsulatus
CBS90643       13 ATRSAAQTAVAAFAAILLGSFLLYGVGFAQPQQ------IHDAAHDARHSFAFPCH 62  Azospirillum lipoferum 4B
jgi:Pnap_2155  13 PASATRSLLLQLAAGAALGLVVLYGVAFAESPL------AHNAAHDVRHVTVKPCH 62  Polaromonas naphthalenivorans CJ2
Q2S8B7         23 PLLASNNAALQLIGAMCFGGLILFAVGFLSMDA------AHNAAHDTRHAFAFPCH 72  Hahella chejuensis KCTC 2396
WP_011322275   12 ELARSDLSLAQVAAALGFGAAIAFTLVFLQEPL------VHDATHNFRHAAGIACH 61  Natronomonas pharaonis
jgi:Htur_5160  13 ETARTELTPMQVATGLLFAAAIAFTLLFLQDPL------AHDAMHNFRHGAGIVCH 62  Haloterrigena turkmenica DSM 5511
CCJ08576       12 LPSSRLEALKAAAVALTLGFGLVWLAGFAYPES------VHDAAHDTRHALSFPCH 61  Methylocystis sp. SC2
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