Conserved Protein Domain Family
OrgA_MxiK

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pfam09482: OrgA_MxiK 
Bacterial type III secretion apparatus protein (OrgA_MxiK)
This protein is encoded by genes which are found in type III secretion operons, and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene. In Shigella the gene is called MxiK and has been shown to be essential for the proper assembly of the needle complex, which is the core component of type III secretion systems.
Statistics
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PSSM-Id: 370521
View PSSM: pfam09482
Aligned: 8 rows
Threshold Bit Score: 189.229
Threshold Setting Gi: 81606421
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBA15992       7 LLRIMLAPDDYLHPERVPMtSAQWCALPKA---VRNTILFDTYDLRTt-SPESIPIDPCTSILLRKWYVIPDLCFLLGLF 82  Xanthomonas alb...
Q2NR75         7 LDSVMFDPLTWIHPSRFAL-PASLDGIAQRs--IVNDMLISLYGLSL--ERPALPTHSLPRQFVEAWHLLPQIALLMACQ 81  Sodalis glossin...
Q326R7         8 YLSIIFDPAFYINRNRLNLpSELLENGVIRs--EINNLIINKYDL----NCDIDPLSGVTAMFVANWNLLPAVAYFIGSQ 81  Shigella dysent...
Q7NVC4         8 LRALLFDPLSYLHRDRLRLpPALAGAEQRR---LVNDMLIAGYRLRT--DWSPDPADRSHGLWLAEWHRLPQAAYLMGCQ 82  Chromobacterium...
Q63K15         6 LMRVMYGPLGYAHPDHRTIaGVDLARMPAD---VANQWLIDHHRLDTaiDFDWR-GAPRAAPCVDHWARLPRIAYLIGVQ 81  Burkholderia ps...
WP_025423339   9 VMRVMYHPVSYLHASRF---PSGWRREDEAahpLLNHWILRHYHCPD--DVGTFSHDPFYRLLIDGWQRLGDAALLIGAH 83  Sodalis praecap...
Q2NVJ5         9 VMRVMYHPVSYLHASRF---PSGWHREDQAahpLLNHWILRHYHCPS--DDGADRGDPFYRFLLDNWQRLGDAALLIGAH 83  Sodalis glossin...
P0CL44        17 WQRIIFDPLSYIHPQRLQIaPEMIVRPAARa--AANELILAAWRLKN--GEKECIQNSLTQLWLRQWRRLPQVAYLLGCH 92  Salmonella ente...
CBA15992      83 SQRGEWLSSNRYRQLDGRCKRFIE----LPLp---------HLAVPACVLDENVDPVVCGLAALRFLIPAMPPVIDERLR 149 Xanthomonas alb...
Q2NR75        82 RHRASLAKGGYGASLPDWLRQFAA----LSLv--------sSRSSPGETIPPPAQLLAWGKYELLAFAGSLPRGLRQRLD 149 Sodalis glossin...
Q326R7        82 ESR--------LINHSEMVISYYG----------------------GKISKQGEAAIRSGFWHLIAWKENISVGVYERIN 131 Shigella dysent...
Q7NVC4        83 LLRARLAARGGLLRLPGWARGFAA----MQIga-------eWPAAPLDEAPGHDAILLAGFGQLLSWRERMPEALAQRLP 151 Chromobacterium...
Q63K15        82 RLRAALVERGRYVRLDASSQRFLC----MPLa--------aVPKAACAGMPDDDAIVAAGTACLTAALHDAPRALRQRLP 149 Burkholderia ps...
WP_025423339  84 LLRNRLLADGRFILLAPPVQSFLA----LPLpqltpaagvhEQEETAAALLHHPDPAAWGAYWLLSRLKHFPPAVYRRAC 159 Sodalis praecap...
Q2NVJ5        84 LLRNRLLSEGRFILLSAPVQSFLA----LPLppltpgalpqEQEEPATTLLQDPDPAAWGAYCLLSMLKRLSPAVYRRAC 159 Sodalis glossin...
P0CL44        93 KLRADLARQGALLGLPDWAQAFLAmhqgTSL-------------SVCNKAPNHRFLLSVGYAQLNALNEFLPESLAQRFP 159 Salmonella ente...
CBA15992     150 LLFSsrieaetaalSLQVGRASPEdcgrwiSITLFSMAAHYAQN 193 Xanthomonas albilineans GPE PC73
Q2NR75       150 LLFP----------PEEGRDDLSRlslpppCRLLLKLAFQHAKR 183 Sodalis glossinidius str. 'morsitans'
Q326R7       132 LLFNpivlegnytpVER-------------NLSRLNEGMQYAKR 162 Shigella dysenteriae Sd197
Q7NVC4       152 LLFPawvdeaspciPAQ-------------NTLLLTLALQYAKR 182 Chromobacterium violaceum
Q63K15       150 LLFPrah----aarLASGLDGAHDdaraawSSSLFSFAVNHALL 189 Burkholderia pseudomallei
WP_025423339 160 LLFPavq-----plPQQATPLSPS------SINLIKMALHHAQY 192 Sodalis praecaptivus
Q2NVJ5       160 LLFPveq-----plPQQATSLSPS------SINLIKMALHHAQY 192 Sodalis glossinidius str. 'morsitans'
P0CL44       160 LLFPpfieealkqdAV--------------EMSILLLALQYAQK 189 Salmonella enterica subsp. enterica serovar Typhimu...
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