Conserved Protein Domain Family
RNase_H2-Ydr279

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pfam09468: RNase_H2-Ydr279 
Ydr279p protein family (RNase H2 complex component)
RNases H are enzymes that specifically hydrolyze RNA when annealed to a complementary DNA and are present in all living organisms. In yeast RNase H2 is composed of a complex of three proteins (Rnh2Ap, Ydr279p and Ylr154p), this family represents the homologs of Ydr279p. It is not known whether non yeast proteins in this family fulfil the same function.
Statistics
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PSSM-Id: 401427
View PSSM: pfam09468
Aligned: 85 rows
Threshold Bit Score: 41.9854
Threshold Setting Gi: 74683166
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:MYCTH_2306825   130 FLLLPALCGAptitTTtttttgrdqerqgqneqeeqsqqrqqKKRLFLSLDDHLDATADP---SGHLADLL---As-CPA 202 Thermoth...
XP_714251           118 YLLISLFSNInqqkSQqqsqqss-------------lssenlFNDNFKSLEDLKDQLLN------EYREDTnnnDwvLEI 178 Candida ...
CCE44718            123 YLLITIFEKHgd------------------------------kfSRFHTLDDIRDRLSS----------LElghDwvYDI 162 Candida ...
EDK44582            101 YLLISIFHTHqekfR-----------------------------NTFKTIDDIRDSLES-----------LgeyTwvYDV 140 Lodderom...
EGW32856             96 YLLISILSSQke--------------------------------dRFITVDDFMDRVAw-----------------sHNL 126 Spathasp...
XP_001384175        106 WLLIAIFYKHnq------------------------------fsKNYISAEDVMDKIAG-------VFSGNgndQwvHKI 148 Scheffer...
Q6BWG7              101 YYLMSIMYNNds------------------------------faKRFITFEDFSDTISS----------LFeynAwvGAV 140 Debaryom...
XP_002619377         98 YFVISVMWHKkelyG-----------------------------GRYHAMDDILDNFSA----------YVkpqKslQDI 138 Clavispo...
WGS:AATM:SJAG_00400  74 PFVLPVLQELtwnrQN--------------------------EPVRYVVLEDIKDSFAARgpaYALVLQILpn------- 120 Schizosa...
XP_013022040         75 IFMLPVLQELtwnrRS--------------------------EPCRFISFDDILDHFNAQgahYSRVSRVLes------- 121 Schizosa...
jgi:MYCTH_2306825   203 TRRRVEARLAAVCDAV--------------------P--AG-DETMYRVSEAKLARELLAKAKRIvgEEaskLPASMEER 259 Thermoth...
XP_714251           179 PDQLYHQSLINLCDVI--------------------T--ENiDESFYRFDLSKILHWLNEKVLALqkYI------LTNDN 230 Candida ...
CCE44718            163 PRVVFLKSLANICESIieggggngdgngeegnrslsDaiEDaGDRFFKYSETKSLEWINSKIVALqqWIlhsDDDKRTTN 242 Candida ...
EDK44582            141 PERIYLLSLDSICESI--------------------I--EGnQERFYKYSVNKAMDWVNGKVIALsnFI-----FEEKGN 193 Lodderom...
EGW32856            127 PESVISNALVQICDEL--------------------D--QG-DAKFYKFSLDKSIQFVNEKITKLveFF------TNEKN 177 Spathasp...
XP_001384175        149 PYFLYEQSLAKISESI--------------------D--ES-GDSFFKFSLKKSFEFVEKKVERLqtYF------ASGDN 199 Scheffer...
Q6BWG7              141 PMTMYKSALSEICETI--------------------E--EN-DEIFYKYSNAKVIEYLHRKVSQLlaYL-----SSQSDL 192 Debaryom...
XP_002619377        139 RPHLVK-SIESLCQVV--------------------E--EG-GEPFYKFSTEKAMKFVSTKIDSLtdLL-----HSSPDY 189 Clavispo...
WGS:AATM:SJAG_00400 121 ---aFLRALNVACSKK--------------------EssNGmPET-YQLSKKQVLTYLQQKIQVAvdNLppsICSHLLQQ 176 Schizosa...
XP_013022040        122 ---kLENTVHRICKVN--------------------AaiGSlPRT-YQLDKDAVIQMLHRKLRVAeeNLptsIIRELNHQ 177 Schizosa...
jgi:MYCTH_2306825   260 FVRRELEPPVLGVRIArgtgsgsesgsgsgtatpassssegesqessvssassaetaassgseestktttstaatsvaad 339 Thermoth...
XP_714251           231 SILTKLKLELNP-------------------------------------------------------------------- 242 Candida ...
CCE44718            243 SIMSKIKKGLHDPTRN---------------------------------------------------------------- 258 Candida ...
EDK44582            194 SIMRRIQLELNDP------------------------------------------------------------------- 206 Lodderom...
EGW32856            178 TVIEKVRAELND-------------------------------------------------------------------- 189 Spathasp...
XP_001384175        200 SVLVTIKGKLTDT------------------------------------------------------------------- 212 Scheffer...
Q6BWG7              193 SIILKIKQELYRP------------------------------------------------------------------- 205 Debaryom...
XP_002619377        190 ALTGFIRNKLN--------------------------------------------------------------------- 200 Clavispo...
WGS:AATM:SJAG_00400 177 LTPVEYGKNV---------------------------------------------------------------------- 186 Schizosa...
XP_013022040        178 LAPLDLDSPI---------------------------------------------------------------------- 187 Schizosa...
jgi:MYCTH_2306825   340 sdegDGVATSATGASDEVVRLQRLRVAFSFICSRYVS-PAIAAMLN 384 Thermothelomyces thermophilus ATCC 42464
XP_714251           243 -------SMSNNNIEDQLLNDLGLLYSIDYIFNSYLD-DGVNSFLR 280 Candida albicans SC5314
CCE44718            259 ----EDTSTNQEEEQNQLMDQMAMIYAIDYVCDSYIP--DTKSKII 298 Candida parapsilosis
EDK44582            207 -------TSIEGHINEEVLQNTVMCCAIDYVCFSYLC-KGVREVLV 244 Lodderomyces elongisporus NRRL YB-4239
EGW32856            190 -------PTSTEVVSQQLVSELTLQYAIDYVCGSYIAePTFKQDLI 228 Spathaspora passalidarum NRRL Y-27907
XP_001384175        213 -------TLAEHTIPEPILKSMVLRYAVDYVCDSYIG-SEFKKEFI 250 Scheffersomyces stipitis CBS 6054
Q6BWG7              206 ------ISEGSNDIPSDILQLSIIRHSIDLICGSYTP-IEIRNQVM 244 Debaryomyces hansenii
XP_002619377        201 ---------AYEEAPDEIFQLQIKKYAVEFIFGSYLT-QEIKHDFM 236 Clavispora lusitaniae ATCC 42720
WGS:AATM:SJAG_00400 187 --------------PDDIVALAKRRCAIGFVCDGIIM--PFASELT 216 Schizosaccharomyces japonicus yFS275
XP_013022040        188 --------------PGDMFQLACKEHAAYLVFEDFSK--DWFNQIA 217 Schizosaccharomyces cryophilus OY26
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