Conserved Protein Domain Family
Vps23_core

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pfam09454: Vps23_core 
Vps23 core domain
ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (pfam03997) and Vps37. Vps23 gives ESCRT-I complex its stability.
Statistics
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PSSM-Id: 401418
View PSSM: pfam09454
Aligned: 103 rows
Threshold Bit Score: 53.6208
Threshold Setting Gi: 124454170
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE79523                      410 NIIIADSPLVNQVYELSGEIRAIRDSLDLLSGKFQgeNEVINdvtLNQCVKLARNLGRELFWLQM 474 Millerozyma f...
CBZ05870                      268 NCLVPADPLQARALELLAEIHAADDTLALLEEGLK--RELMT---CDEYVKNVSDVGREQFVSRH 327 Leishmania ma...
Q4DWG4                        282 TCIEPVDDLQTHALELLSEIHALDDALELLERSLK--AGQLS---CEEYVRRVSDMGRKQFEARF 341 Trypanosoma c...
Q59WF8                        408 EIVIADSPMIDTLYKVSAEINSITDTINLISGNFHneQEIVNeksFDSCLKTTRKMGRELFWLhf 472 Candida albicans
XP_006689532                  412 EVVISDSVLTNQLYEISSEIKANNDCMSLIGGSFDneNELIDdasFDTCVKTVRGIGRDIFWLKL 476 Yamadazyma te...
A0BPW4                        218 lqhisTTPYQDQLIELDAKIKGIRDTLRLIQHNFQ--NNHLN---FLELNQFTRNLAKEEFDAFL 277 Paramecium te...
A0BV93                        339 qniRENDQFSTSILELYSDIQACRETLHFIVTKFK--NFNLP---FETVIKMTRKYSEEQFNNIL 398 Paramecium te...
A0CR15                        375 eelmQTDPLSNQIIDLTSEIQAQKEGLYYVQKKFR--HQNLD---YDQLIKITRQMSQQMFDQYL 434 Paramecium te...
WGS:AAGF:cds.TTHERM_00486330A 261 kyMTAQSPVHNQILQLIAELDAIKETFLFTDEWFK--RSK-D---FDQYSSQIKLLAEREFECKI 319 Tetrahymena t...
Q24HU3                        343 NFIKEQNPLQNQILELTSEQEAIKETIIYIEEAFK--QKKID---FETLIKSIQYYSELEFNTKL 402 Tetrahymena t...
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