Conserved Protein Domain Family
HIRA_B

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pfam09453: HIRA_B 
HIRA B motif
The HirA B (Histone regulatory homolog A binding) motif is the essential binding interface between HIRA pfam07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus.
Statistics
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PSSM-Id: 401417
View PSSM: pfam09453
Aligned: 39 rows
Threshold Bit Score: 36.7138
Threshold Setting Gi: 238484879
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX33021      472 KQKITITKDGKKRVAPLLVSTGG 494  Pyronema omphalodes CBS 100304
CCJ29440      393 QQKVTITKDGKKRVAPQLLSNLS 415  Pneumocystis jirovecii
CAP24418      735 nKQIEVVKDGKRRIQPVFCGTTA 757  Caenorhabditis briggsae
Q86HX1        458 NQKQTIMPGGKRRITPIFIGSSS 480  Dictyostelium discoideum
EGG11238      433 pQQMTIMPNGKRRIRPVFLGQNE 455  Melampsora larici-populina 98AG31
ELU36609      465 QQQVTITKDGRRRIKPSLIGHLN 487  Rhizoctonia solani AG-1 IA
XP_001629736  443 QQRETRTKDGRRRITPVLVAQMD 465  starlet sea anemone
XP_002011077  428 KQTETRTKDGKRRITPMFIPLND 450  Drosophila mojavensis
XP_001524869  628 TQKVS-TKNGKRRIQPTLLSNGN 649  Lodderomyces elongisporus NRRL YB-4239
CCA76600      212 aQKVTMTKSGKKRIQPTFLGGGS 234  Serendipita indica DSM 11827
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