Conserved Protein Domain Family
Methyltransf_15

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pfam09445: Methyltransf_15 
RNA cap guanine-N2 methyltransferase
RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.
Statistics
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PSSM-Id: 370496
View PSSM: pfam09445
Aligned: 9 rows
Threshold Bit Score: 174.445
Threshold Setting Gi: 74882952
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BUU2        81 CRKVLDICCGGGGNTIQFANY---FPSVGSIDINPSNMKCTLHNARVYGV-EDRIWSKVGDWNQfslvladgs------- 149  Debaryomyces h...
Q6FK05       131 AKRILDVFSGGGGNSIQFANV---FDRVYCLDSNLEHLYCSIKNGQSYGV-SNKLWMCKGKWGE---------------- 190  [Candida] glab...
Q09814        73 pELIIDAFSGCGGNTIQFAK----YCPVISIEIDPIKIAMAKHNLEIYGIpSSRVTFIQGDVLD---------------- 132  Schizosaccharo...
ESA44168      81 kRVLIDLFGGAGGNVIAFALSsgrWDRIIAIEKDRSTLACAQHNAEVYDV-LDKITWVHGDCFEvmkrfwkttrgtkgme 159  Neurospora cra...
Q7RPD6       212 ITIHLDPFSGAGGNCNTMKNV---F--TIASDINLNRLKQCQHNCKFY---NNNIDYILCDFFS---------------- 267  Plasmodium yoe...
XP_001707121  79 RGYVLDLFGGAGGQAIGFALE---GHSVHSIEYSEQHCALIHNNARVYGV-SHLVFPVCCDVFTq--------------- 139  Giardia lambli...
Q12052        98 AERILDVFCGGGGNTIQFAMQ---FPYVYGVDYSIEHIYCTAKNAQSYGV-DDRIWLKRGSWKK---------------- 157  Saccharomyces ...
Q6CRW0       100 GNCIVDVFCGGGGNTIQFARL---FEKVYGIDSNIDHLYCAYKNAECYNS-AVKLKLIYGDWEE---------------- 159  Kluyveromyces ...
Q75BX4       119 ATTILDVFCGGGGNVVHFAKV---FQKVYGVELKLEHLYCTYRNAEAYGV-ADRVWLKHGDWLQ---------------- 178  Eremothecium g...
Q6BUU2       150 -------------------pnqlwippHLRNvKTPSA--IFDFVFCSPPWGGPSYKDTNGFDV-Y-NMQPFPIDQLCHQ- 205  Debaryomyces h...
Q6FK05       191 ---------------------------HTAK-KFRKL--NIDCIFGSPPWGGPEYIKDEKYDLeK-SLLPFGLYKLLKT- 238  [Candida] glab...
Q09814       133 ---------------------------TFKSlQFAKD--YRSLVFMSPPWGGPSYSGKTVYSL-N-DLNPYAFDVLFKE- 180  Schizosaccharo...
ESA44168     160 mkgrgreggeaankgqeqeddneeldgLLAGlKLEEC-----LVFASPPWGGVSYRDQEVFDL-S-KMEPYNLEQLYKAc 232  Neurospora cra...
Q7RPD6       268 ---------------------------IVNHfRENVI----DVVFLSIPXGGPSYKKQNKFDLkN-KEKNLCVYTCLKE- 314  Plasmodium yoe...
XP_001707121 140 ---------------------------ALRFcTSGATpqKYDCVVLSPPWGGPGYWRNGDLDFcKlRINKYKGSQLVSLm 192  Giardia lambli...
Q12052       158 ---------------------------LVSKqKLSKI--KYDCVFGSPPWGGPEYLRNDVYDLeQ-HLKPMGITKMLKS- 206  Saccharomyces ...
Q6CRW0       160 ---------------------------SLKKtLVKNLgkTPDCIFASPPWGGVDYLRQDTYDLeE-HLQPSPLSKILSV- 210  Kluyveromyces ...
Q75BX4       179 ---------------------------LAARgRFERV--HVDCVFASPPWGGIDYTKTQAYDLeT-QLQPAGLSQLLSS- 227  Eremothecium g...
Q6BUU2       206 -----------VMQYTQNFG---LFLPRSTNLDQL--------------------------------------RRLTTDI 233  Debaryomyces h...
Q6FK05       239 -----------FKIVSDNII---LFLPKNSNLDQL--------------------------------------SETTKEV 266  [Candida] glab...
Q09814       181 -----------ATRISPYVA---AFLPRNTDVKEL--------------------------------------AAYG-SI 207  Schizosaccharo...
ESA44168     233 tmpqeakeehpSTQKQKHILpqaLFLPRQSDLNQI--------------------------------------AAL---V 271  Neurospora cra...
Q7RPD6       315 -----------SIKLTKNII---IYLPRNVCINDLyflfktykklctlknkdtkinyienkkverkkynfskkYDMLIEL 380  Plasmodium yoe...
XP_001707121 193 cr-------lvDSGISKRFI---LHLPRNTTTRSI--------------------------------------YSVGARV 224  Giardia lambli...
Q12052       207 -----------FLKLSPNVI---MFLPRNSDLNQL--------------------------------------SRATRKV 234  Saccharomyces ...
Q6CRW0       211 -----------FFSVCQNVV---LFLPRNSDLDQL--------------------------------------SSITHDL 238  Kluyveromyces ...
Q75BX4       228 -----------FLRISANVV---LFLPKNSNLQQL--------------------------------------SEITRSL 255  Eremothecium g...
Q6BUU2       234 YGQSGKCR-----------------IIFLNINGYCKGLLALFGPS 261  Debaryomyces hansenii
Q6FK05       267 FGPEAKCK-----------------VLYIKEQGYLKGMLCLWGSA 294  [Candida] glabrata
Q09814       208 HNKPY--------------------ITNFLFEGYAKAICCYFNMK 232  Schizosaccharomyces pombe 972h-
ESA44168     272 PEGAPKID-----------------VVQYCQKGASKALVAYLPGn 299  Neurospora crassa OR74A
Q7RPD6       381 YVNRNRCT-----------------YKDICENNLMNYYYYYFNKK 408  Plasmodium yoelii yoelii
XP_001707121 225 ARHISRVAiqelgstkadfltssviVSEMQLNGRVSFLAVYIGCW 269  Giardia lamblia ATCC 50803
Q12052       235 LGPFAKCK-----------------VLYVKENGYMKGIFCMWGEC 262  Saccharomyces cerevisiae S288C
Q6CRW0       239 LGPDEKCK-----------------VVYVKDNGYMKGILAFWGRP 266  Kluyveromyces lactis
Q75BX4       256 LGPEAKCK-----------------VLYARENGRDKGLLCFWGEA 283  Eremothecium gossypii
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