Conserved Protein Domain Family
WTX

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pfam09422: WTX 
WTX protein
The WTX protein is found to be inactivated in one third of Wilms tumors. The WTX protein is functionally uncharacterized.
Statistics
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PSSM-Id: 401395
View PSSM: pfam09422
Aligned: 16 rows
Threshold Bit Score: 433.867
Threshold Setting Gi: 380876857
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
E1C2Q8         57 GMVRSRTHDGL-ADA-VlESGKKEDagggeaqgkdapS------------------------RAAGGLGGSASSSVAKSH 110  chicken
XP_005990615   56 GMVRSKTHDGL-ADVvV-EGSKKGEssssdqlntdtnT------------------------KTVTSASVSLSSSVAKSH 109  coelacanth
EDL95988       89 GLNKSKTHDGL-SESsHgPEDVVVE------------E------------------------TELSTPLSKSPSQFPSSQ 131  Norway rat
Q5JTC6         89 GLSKSKTHDGL-SEAaHgPEDVVSE------------G------------------------TGFSLPLPELPCQFPSSQ 131  human
4_pfamImport    1 ELVRSKTHDGL-TSSnSdADGQRGE--------------------------------------GLAILEAGPVRSLSKSL 41  
5_pfamImport    1 ELVRSKTHDGL-TGSnNeAVGQRGE--------------------------------------GLTSLEAGPVRSLSKSL 41  
XP_007252366   59 ELARSKTHDGLvTDVpSdLEGSKKEdscss--dllhsA------------------------PVEGVSLAPVRSAITKSF 112  Mexican tetra
F1QGH6         60 ELVRSKTHDGLiTDTpSeLDSHRKEesass--dqlhaG------------------------TPDGVSTAPLRSSITKSF 113  zebrafish
VTJ64886      101 GMVRSRTHDGL-AEVvVlEGSk---------------KeepraggdsgggrgggrpnpgpprAAGTGVGSLANSSVAKSH 164  woodchuck
XP_005471779   77 ELVRSRTHDGL-TSSnNdADGQRGE--------------------------------------GLAGLEVGPVRSLSKSL 117  Nile tilapia
E1C2Q8        111 SFFSLLR-----KNGRPENGKAAENAEqRAGGRQKKGLKGIFSSMRWHRKDKIGKEERGE----ASEIPSGLIMP----- 176  chicken
XP_005990615  110 SFFSILK-----RNGKSENGKGENSDQ-KAGNRQKKGLKGLFSSMRWHKKDKSHKEEKED----SSENQSSIILP----- 174  coelacanth
EDL95988      132 SAHGALEigsrhKTSVTEAVEKAGVEKvPSVHKPKKGLKGFLNSIRRHRKSKVSGADQSGlgakELE------------- 198  Norway rat
Q5JTC6        132 SAHGALEtgsrcKTSVAGATEKAVAEKfPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEpgakGPE------------- 198  human
4_pfamImport   42 SFFSLLR-----RGSFRSGENGG-----AGLVRRGRGLKGFFSSMRWRRKEKTNEVDAEEaerkAEKdgevg-------- 103 
5_pfamImport   42 SFFSFLR-----RGSFRTSENGG-----TGIVRRGRGLKGFFSSMRWRRKEKTSEAEGEEvegkKAR-DTDATESet--- 107 
XP_007252366  113 SFFSLLR-----RNSTRVGDGA------ATLGHRGRGLKGLFSSMRWRRKPPPREDSSEIqevaKEVKEGDVILPstsnk 181  Mexican tetra
F1QGH6        114 SFFSLLR-----RSSSRAGDGT------TTVGRRGRGLKGLFSSMRWRRKPQIQEDTle---vaKEVKEGDLILSsssgs 179  zebrafish
VTJ64886      165 SFFSLLK-----KNGRSENGKGDPADAsKAGGKQKRGLKGIFSSMRWHKKDKRGKEEEKEa---HAAGQGSLILP----- 231  woodchuck
XP_005471779  118 SFFSLLR-----RGSFRSSENGG-----AGLVRRGRGLKGFFSSMRWRRKDKTNEGDGEEaeakKDKdgdaa-------- 179  Nile tilapia
E1C2Q8        177 -----GSLTASLECIKEETPKPLSETPNGAGDTGVESQQEKRGGDAC--VSAEEP------QAGGGESRDSKTPPGedpa 243  chicken
XP_005990615  175 -----GSLTASLECVKEKVQKPLSELENDREQAEKESPCESNSNEVN--ASVNKPeamdcgEPSCMLDNNKNIKEG---- 243  coelacanth
EDL95988      199 -----GTRTMSQEHVSSIS-LPSSE------EIFRDAIKENTKPQDApgPKMSPAre-----hfSLTTEKTACKNPeklt 261  Norway rat
Q5JTC6        199 -----RVRARPHEHVSSAPQVPCFE------ETFQAPRKENANPQDApgPKVSPTpe-----psPPATEKMACKDPekpm 262  human
4_pfamImport  104 dperaKDITLTLEP----------PPHHHQVDCGDAAASPD---PEThsTSVTITpplcvvAMPGQSCEPDS-------- 162 
5_pfamImport  108 ----lKDITLTLEP----------PPHHHQEDCASAETGSNLQASDTptTSVTMTpth-cvAMPGPSGEPDS-------- 164 
XP_007252366  182 vetleDSVTLTLEPTVRVFEECPTEDNSGTWDKNSLEEVKSSNE-ESrkSSCSLVq-----------------------e 237  Mexican tetra
F1QGH6        180 -vkteKDMTLTLEPLPQVFEESPLPGDSDKWKVASMQGIQGTNEVECgnCGPSVSqq---------------------ht 237  zebrafish
VTJ64886      232 -----GSLTASLECVKEETPRAACEPETPSQDAPRDPAGELGGGEEVpaSA-DRApartcrEAESPGCPNDKSARGe--d 303  woodchuck
XP_005471779  180 daekvKDITLTLEP----------PPHNHQADCGDAEAGPNLQALETptTSVTMTpph-cvAMPGPSGEPDS-------- 240  Nile tilapia
E1C2Q8        244 AAARRLEELCGERPDPGAGEVGTAKDAAITGDIPITTIPPVEPHcdsgqetaaapdpSSVDPPSEQSIDRIC-LMFADVT 322  chicken
XP_005990615  244 IATEIKQESLALLPDTSKEQIQVKEAEAITGDIPEQGTALTKPKcvsape-taapepSTIDPPSEQSIDRIC-LMFADVT 321  coelacanth
EDL95988      262 MTCASEFMQPKPILEASSLEEPHTSETEGKVVT------------------------GDANPPNGPVGDQLS-LLFGDVT 316  Norway rat
Q5JTC6        263 EACASAHVQPKPAPEASSLEEPHSPETGEKVVA------------------------GEVNPPNGPVGDPLS-LLFGDVT 317  human
4_pfamImport  163 PIPYTPTDSPLRPPT-------QKAKASISSLTPSLATPPLDRC-------------SNGDPPSEPSVDRLCsLLFTDVT 222 
5_pfamImport  165 PFPYTPTDSPLRPSI-------QKAKASISSLTPSLTTPPLDRC-------------SIGDQPSEPSVDRLCsILFTDVT 224 
XP_007252366  238 ITEESPAPSPLRVPTEGPLRANTSGSACLTSIPASAMTPPLEH--------------SSVDPPSEPSVDRLC-SMFTDVT 302  Mexican tetra
F1QGH6        238 VTEESPAPSPLRVQTGGLQNHKHSSSTHLSSIPTCALTPPMEH--------------STADPQSEQSVDRLC-SMFTDVT 302  zebrafish
VTJ64886      304 AAGHRRAEKPRAPPESGAGEVHTAEDASRTGDVPIKTVPLVDSEcgsgrasavpdpsS-VDPPSDPSADRIC-LMFSDVT 381  woodchuck
XP_005471779  241 PFPYTPTDSPLRPPI-------QKAKASISSLTPSLATPPLDRC-------------STGDPPSEPSVDRLCsLLFTDVT 300  Nile tilapia
E1C2Q8        323 SLKSFDSLTGCGDIIADQEEDVGggsGGCEKSTPGAGKLGAPKK------------------------------------ 366  chicken
XP_005990615  322 SLKSFDSLTGCGDIIADQEEEGG---NGGDKAAPAEKGQGTSKK------------------------------------ 362  coelacanth
EDL95988      317 SLKSFDSLTGCGDIIAEQDMDSM---TDSMASGGQRANRDGTKR------------------------------------ 357  Norway rat
Q5JTC6        318 SLKSFDSLTGCGDIIAEQDMDSM---TDSMASGGQRANRDGTKR------------------------------------ 358  human
4_pfamImport  223 SLKSFDSLTGCGDIIADAEEDg----PGGN------------ARarappp------------------------------ 256 
5_pfamImport  225 SLKSFDSLTGCGDIIADADEE-G---PGGN----VPPPPQQHSA------------------------------------ 260 
XP_007252366  303 SLKSFDSLTGCGDIIADQEEDSGnggSATSSGTGSSSGGCGGRRvigaatercspvkpplppqvts-------------- 368  Mexican tetra
F1QGH6        303 SLKSFDSLTGCGDIIADPEEDSGnggSATSSGTGSSSGGCMGRRlsgagtnsercspakpplppqvss-----------l 371  zebrafish
VTJ64886      382 SLKSFDSLTGCGDIIADQEEEAG---PSCDKHAPGPGKPVLSKK------------------------------------ 422  woodchuck
XP_005471779  301 SLKSFDSLTGCGDIIADADEEg----PVGNGGSGTSSSSSGGGGgsvgvgigrvvgitssispskpplssqmsqpmfsvs 376  Nile tilapia
E1C2Q8        367 -----------------------HPTMVAYQGGGEEMASPD-------------------------QVDDTYLQEFW--- 395  chicken
XP_005990615  363 -----------------------NSNIVAYQGGGEEMASPD-------------------------EVDDAYLQEFW--- 391  coelacanth
EDL95988      358 -----------------------SSCLVTYQGGGEEMALPDdddneeeeeedeeveledeeeevkdGEEDDDLEYLWasa 414  Norway rat
Q5JTC6        359 -----------------------SSCLVTYQGGGEEMALPDdddeeeeeeeev--eleeeeeevkeEEEDDDLEYLWeta 413  human
4_pfamImport  257 -----------------pqphpaGSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW--- 291 
5_pfamImport  261 -----------------------GSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW--- 289 
XP_007252366  369 -rvsispylsshqrmssspkkpqGSGIVAYMGGGEEMASPE-------------------------GVNDADMQGLW--- 419  Mexican tetra
F1QGH6        372 asihascympahqrpraapkkpqGSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW--- 423  zebrafish
VTJ64886      423 -----------------------NPSVVAYQGGGEEMASPD-------------------------EVDDTYLQEFW--- 451  woodchuck
XP_005471779  377 qnsapaslpartraqpqpqqhppGSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW--- 428  Nile tilapia
E1C2Q8        396 DMLSQTEETetggggGGGGGTKT------------PEGLKENrgteg--------aqnrvAVKRGGLNQIPIh------- 448  chicken
XP_005990615  392 DMLPQTEES------PSEQQNQAtppsnpteqkkcPEEAVGN------------------TVKLLDIGKRSV-------- 439  coelacanth
EDL95988      415 QIYPRFNMNlg---yHTAISPSHqgymlldpvqsyPNLGLGEll------------------------------------ 455  Norway rat
Q5JTC6        414 QMYPRPNMNlg---yHPTTSPGHhgymlldpvrsyPGLAPGEll------------------------------------ 454  human
4_pfamImport  292 HMLPSTGDN-------SPALPRShqtpsttptstyPPRATTNaagchllsahrsadrrlpPVKALGLSKIPVvgaaggra 364 
5_pfamImport  290 HMLPSAGES-------SPALPRQyqpssstltstyPPRSNSPsalrpsaq--rsaerkapQVKSLGLSKIPVvggagsra 360 
XP_007252366  420 HMLPQKGED-------SPALPRSdpi------vhhPPGrqek---------------khpQVKSLGLSKIPVcgis---- 467  Mexican tetra
F1QGH6        424 HMLPQKDED-------SPAPRRAepv------lhhAPArlek---------------rppQVKALGLSKIPVsgss---- 471  zebrafish
VTJ64886      452 DMLSQTEDQgq---gPQEGAAKVaaale---tkvvPETSKDArsvea--------skdvsLVKRRRLNRIPIe------- 510  woodchuck
XP_005471779  429 HMLPSTGDN-------SPALPRShqpssstptstyPPR--TNpassylpsasrssdrkvpQvkalglskipvvggagsra 499  Nile tilapia
E1C2Q8        449 -------LNNKEEQKG--REKEQHEGVPNSDEGYWDSTTPGPE---EDS---TTSIQKETLPRDSYSGDALYDLYAEPDE 513  chicken
XP_005990615  440 -------TNSDNSDDS--IEKEPQECIPNSDEGYWDSTTPGPE---EDSg--NTFVQKESLPRDSCSGDALYDLYADPDE 505  coelacanth
EDL95988      456 -----------------tPQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVHRDCLPRDSYSGDALYEFY-EPDD 514  Norway rat
Q5JTC6        455 -----------------tPQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVRRDCLPRDSYSGDALYEFY-EPDD 513  human
4_pfamImport  365 akppiphAHGRHAASP--GEKE-----PLSDEGYWDTPTATPTatpDESg--QQRNRKTALTRDSCSGDHLYDLYNDPEG 435 
5_pfamImport  361 gkpplphAHGRHPVSP--GEKE-----LLSDEGYWDTPSATPTatpDESg--LQRNQKIALSRDSCSGDHLYDLYNDPEE 431 
XP_007252366  468 ---ktgkQQSAHPSPP--PTDKELHDAPPSDEGYWDSPTPGPE---DED---NGFTRRDGLLRDSCSGDALYDLY-DLDS 535  Mexican tetra
F1QGH6        472 ---ktgkQQPSRPSPP--PVDKELQDAPPSDEGYWDSPTPGPE---DED---STFLRRDGLLRDSCSGDALYDLY-DPDS 539  zebrafish
VTJ64886      511 -------SHPKEQPKHpeKEKEQQEGVPNSDEGYWDSTTPGPE---EES---ASSGKKAGIPRDSYSGDALYDLYADPDG 577  woodchuck
XP_005471779  500 akpplphAHGRHPTSP--SEKE-----PLSDEGYWDTPSATPTatpDESg--LQHNQNMALSRDSCSGDHLYDLYNDPEE 570  Nile tilapia
E1C2Q8        514 NPPGGPP---EEEVTCMPRSK-PVS 534  chicken
XP_005990615  506 SLAGMAS---DEEMSSLSESK-PLS 526  coelacanth
EDL95988      515 SLEHSPP---GDDCLYDLRGR-NSE 535  Norway rat
Q5JTC6        514 SLENSPP---GDDCLYDLHGR-SSE 534  human
4_pfamImport  436 AGEDVEQegdEDLNSTPSPSS-EYK 459 
5_pfamImport  432 EGEDQRGd--NDVNSTPSPSA-EFK 453 
XP_007252366  536 PGAGGSDd--DDNMSSPTPSTgDLK 558  Mexican tetra
F1QGH6        540 PSAAGSD----DDASSPTKSAgDLK 560  zebrafish
VTJ64886      578 SPAVPPA---NEETSCLSRLK-PVS 598  woodchuck
XP_005471779  571 EAED--QggdEDPNSSPSPST-EYK 592  Nile tilapia
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