3V9R,3VH5


Conserved Protein Domain Family
CENP-X

?
pfam09415: CENP-X 
Click on image for an interactive view with Cn3D
CENP-S associating Centromere protein X
The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.
Statistics
?
PSSM-Id: 401390
View PSSM: pfam09415
Aligned: 83 rows
Threshold Bit Score: 47.1593
Threshold Setting Gi: 209583612
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3V9R_B            4 KEALIKILSQnE-GG-ND---XKIADEVVPXIQKYLDIFIDEAVLRSLQsHK-------Dinger--------------- 56  Saccharomyce...
EGG20442         16 PKTVESILRL-AiKD--K---IKISKESTQLTAAYLEWMIAECFKRMTKqAE-------Idea----------------- 65  Cavenderia f...
EEC14788         43 TKTIQELMLM-GfQD-EK---TKMNAQALKLTCEILRLLAHEGAARASMqAK-------Lqgd----------------- 93  black-legged...
NP_001077843     12 ihaifkhIWArRfRErERsdaIDATEAEVALGTTKKNRLASEAVQRAAIiAE-------Aegm----------------- 67  thale cress
EFX80651         19 eglIHELMKM-YtTN-HK---TKIGNEAVTAVNEIMLKFLNEVVWRAMNqAH-------Negl----------------- 69  common water...
XP_019849221      9 QETVLQILKS-NfSD-SK---TKVNNDALKLMKKYVDILVLETVFRTIDqAK-------Ieqs----------------- 59  Amphimedon q...
NP_001268381     26 kdVIKELLEN-HfQE-SK---TKIAPHALMLLADVAKCLVTETCLRAVKqAQ-------Regs----------------- 76  domestic sil...
OWR49930         23 QDIVKELLKS-SfQD-SQ---TKLSCEALSLMTEIAKLLVMETCLRAADlAN-------Sgnedg--------------- 75  Danaus plexi...
NP_001289984     12 KETVAKLLSR-SfRE-DK---TRVSSDAVVLVAEMLKVFVEEATRRAIKqAS-------Sedc----------------- 62  zebrafish
jgi:THAPS_10906  28 gdltRKCLQLhH----PY---QKIASDAVDLSSELLKLLVVEARRRAAIeAEcdaavsdTgnksesdgsqswmkdsyede 100 Thalassiosir...
3V9R_B           57 ------gdkspLELshQDLERIVGLLLXD 79  Saccharomyces cerevisiae S288C
EGG20442         66 ---------seIGL--EQLEKIMAQLLMD 83  Cavenderia fasciculata
EEC14788         94 ---------heVTL--EHLEKILPQLVrp 111 black-legged tick
NP_001077843     68 ---------ekIEA--THLERILPQLLLD 85  thale cress
EFX80651         70 ---------nnVNL--DNIEKILPQLLLD 87  common water flea
XP_019849221     60 ---------daVEL--QHFEKVLPKLLLD 77  Amphimedon queenslandica
NP_001268381     77 ---------nkVDV--EHIEKCLPQLMld 94  domestic silkworm
OWR49930         76 ------qvcsvINA--DHILKCLPQIMLD 96  Danaus plexippus plexippus
NP_001289984     63 ---------dtVTI--EHFEKILPQLLLD 80  zebrafish
jgi:THAPS_10906 101 ndtlttkkkkvVEIraDHISKIAAELLMD 129 Thalassiosira pseudonana CCMP1335
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap