2C1W


Conserved Protein Domain Family
XendoU

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pfam09412: XendoU 
Endoribonuclease XendoU
This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.
Statistics
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PSSM-Id: 401387
View PSSM: pfam09412
Aligned: 88 rows
Threshold Bit Score: 212.028
Threshold Setting Gi: 284091064
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2C1W_A         9 NHELSKLFNELWDADQNRm------------KSGKDY-RISLQGKAGYVPAGsnqarDS----------------ASFPL 59 
XP_003109335  27 NAELLAMAKKLRQVDTNR-------------ARPDQI-KLNYQKHTVTRDDS-----DA----------------APAKL 71  Caenorhabditis ...
CAP24636      63 NAELLALAKKLRQVDVHR-------------ARPDQI-MLNYQKHTVTRDDS-----DS----------------APAKL 107 Caenorhabditis ...
EFC44713       6 YQFSATLMDEIWQADENRl------------TP---V-KIKPQGPIGGEYICvvcgmDRkrsnpnftlfklyqydATKHV 69  Naegleria gruberi
XP_002070081  53 pDDVLSLSKSLYA-EESA--------------SSPYIyKLNLQGRTTSGAHD-----DK----------------APKSL 96  Drosophila will...
EDW41986      54 PDDVLTLSKNLYA-EETE--------------VSPYLyKVNIQGKTTSGAHD-----DR----------------APRNL 97  Drosophila sech...
XP_002053222  56 PDDVLTLSQALFT-EETA--------------SSPYLyNVNLQVKTRAGAHD-----DR----------------APHPL 99  Drosophila virilis
Q9GYM9       307 DAALQTLVDKMWGDDQDR-------------PSATQV-TMNWGEHISGKTGT-----------------------KGANL 349 Caenorhabditis ...
PDM80296     507 dlELQDLVNNMRAQDDDK-------------PMSSQY-LLTWGDKLGKNPKP-----------------------SGKDL 549 Pristionchus pa...
Q7NF33        34 RRQTMTIYQKLWDSDENRftvtqrneagewaDPQAEV-FLDAQVRASGKRSL-----DL----------------AAGPL 91  Gloeobacter vio...
2C1W_A        60 FQFVDEEKLk--SR---KTFATFISLLDN--YEMDTG----VAE--VVTPE------EIAENNNFLDAILETKVMKMAHD 120
XP_003109335  72 FSKVDTSLF---RK---PSYELYLNLMDN--FNRQTG----IIEprVTQSE------EKNEVGKFLDYVLETNPMKELYN 133 Caenorhabditis ...
CAP24636     108 FSRVDSSLL---RK---PSYELYLNLMDN--FNRQTGrklrLENswIMSWR------QNQCKSCTIGSKLKVRHHNNYFE 173 Caenorhabditis ...
EFC44713      70 YVQVKNSEFlqsNSkqaKNYKLISRLFDN--YSLDQH----SRE--VNTEE------ERKEVEQFLESIVQTKCMRILGQ 135 Naegleria gruberi
XP_002070081  97 FE-LHQDLLsrdAN---STTALLLRLFNN--YELDVA----VAE--HVTPE------HKEEQHEFLRAIMQTRIMKLAMR 158 Drosophila will...
EDW41986      98 FE-LHQDLLardAN---STTALLMRLFDN--YELDVA----VQE--HPTPE------HIQEQHDFLRAVMGTRVMKLTMR 159 Drosophila sech...
XP_002053222 100 FE-LHYDLLtrdAN---STTALLMRLFNN--YELDVA----VPD--QITAE------HEQEQLDFLRAVMNTRVMKISMR 161 Drosophila virilis
Q9GYM9       350 FTTVDESIF---------TKKQYADLITT--YTQDLF----TAD--VCKAEpamggfRKQYLQGVFNTFTATPMFASAFA 412 Caenorhabditis ...
PDM80296     550 VSNVDESLF---DT---PVYAALKKVYDNgiLVPDVC----TTEtdYNSGF------KRSILQSLLDTWSTTKPFQLMHD 613 Pristionchus pa...
Q7NF33        92 FAKVEEAKL---RK---PTYAAFIALLDN--YATTAR----VAE--SYDSG------EEEEIQDYLEVIRETVPVRLARE 151 Gloeobacter vio...
2C1W_A       121 YLV-RKNQa-KPTR-NDFK-VQLYNIWFQLYSRApGSR---PDSCGFEHVFVGEsKR---------G-QEMMGLHNWVQF 183
XP_003109335 134 WFK-AKGHsiAANP-TAFR-FWIGQLWFSHYSRA-LGR---PDTSGFEHVFIGE-AK---------N-GEISGMHNWVRF 195 Caenorhabditis ...
CAP24636     174 RTN-LLGHpiATSP-QNFR-FWIGQLWFSHYSRA-LGR---PDTSGFEHVFIGE-AK---------N-GEISGLHNWLRF 235 Caenorhabditis ...
EFC44713     136 KYM-------KLSTpTELK-VKLREIWFKQYNLH-NYK----DLSGFEHLVVGE-KN---------G-DKVSGYHYWFKY 191 Naegleria gruberi
XP_002070081 159 YLM-HKGIv-SSDY-DEQF-KLLQDLWFTPYSRG-GGI---VGSSSFEHVFMAE-IR---------N-QNVLGLHNWLYF 219 Drosophila will...
EDW41986     160 YLV-HKDIv-SVEY-DDQL-RLLQELWFTPYSRG-RGI---VGSSSFEHVFMAE-IR---------D-QKVLGLHNWLYF 220 Drosophila sech...
XP_002053222 162 FLA-KRGIv-SSDY-DEQL-KLLQELWFTPYSRG-KGI---VGSSSFEHVFMAE-LR---------D-QKVLGMHNWLYF 222 Drosophila virilis
Q9GYM9       413 YLQ-SINYkeTSNL-TNFKtKVLWPLWFGTYTRC-KGP---LGSSGWEHVFSGE-IK---------S-NEVDGQHDWVRY 475 Caenorhabditis ...
PDM80296     614 FLV-GRGKv-PADL-TQFK-QFLTTFWFGTYTRC-SDKk-tIGSSGFEHVFSGE-WK---------G-TTIDGHHNWMKY 676 Pristionchus pa...
Q7NF33       152 YINgDLGR--NLSE-VQFM-AALRRIWFELFTNY-FQGksqEYCSGFEHVFVGE-AKydtrfggaeNlGEISGYHNWIKF 225 Gloeobacter vio...
2C1W_A       184 YLQEK--RK-NIDYKGYVarqnksrpDEDDQV-LNLQFNWK-----------EMvKPVGSSFIGVSPEFEFALYTIVFLA 248
XP_003109335 196 YALENnrTE-NFDYKGFT--------VKRFNImAALKFTWD-----------GLlKRAGSILIGTSPEFDMALYTMCFLS 255 Caenorhabditis ...
CAP24636     236 YVLENnrTE-NFDYKGFT--------VKRFNImGALKFTWD-----------GLlKRVGSILIGTTPEYDMALYTMCFLS 295 Caenorhabditis ...
EFC44713     192 LLDDStdNHtGQDVISFAgrl--dneSTPDYV--CVRFKQDedvdgdgqsdnQLfKSCGSFFVGISPECLLALSTLAYLE 267 Naegleria gruberi
XP_002070081 220 AEQEQ--QG-RIDYKGWLkhl--emgKPNQMV-LNERHTFY-----------GItKPSNSFLVGTSPELGMSLYTVCFLT 282 Drosophila will...
EDW41986     221 ADQEQ--RG-NVDYKGWLnhk--emgKHNQMV-LSVRYTFH-----------NInKPVNGFFVGTSPELDLALYTACFLA 283 Drosophila sech...
XP_002053222 223 AEQEQ--QG-HVNYKGWLnrf--dtgRHNQFA-LAFRMSFF-----------GIeKSFNGFLVGTSPELEMSLYTVCFLA 285 Drosophila virilis
Q9GYM9       476 YTEQK--AD-KMVYDGYY--------THDENLiGTFQYKWN-----------GAlKPKGGFFTGTSPAFDFSILSVCALA 533 Caenorhabditis ...
PDM80296     677 YINQK--AG-EIKYYGYY--------SEQGQLtGTYEYDWA-----------GLnKKTGGMLFGTSPVFDFSLFTACSLT 734 Pristionchus pa...
Q7NF33       226 FLDEK--FG-RVNFLGYKydlrgeetPDNPNV-VTLQMEWElknmggetlarLF-KKKGGFFVGTSPECEIAMGTVAFYE 300 Gloeobacter vio...
2C1W_A       249 SQEK-----MSRevVRLEEYELQIVVNRH-------GRYIGTAYP 281
XP_003109335 256 RRGRe----TCD--VELDGCPLQITSFEImq---qnKVYIGSIYP 291 Caenorhabditis remanei
CAP24636     296 RRGRe----TCD--VELDGCPLQITSFEImq---qnKVYIGSIYP 331 Caenorhabditis briggsae
EFC44713     268 SLQPsgkknLSD--VKINGNRYVINVFNE-------GGYPRSIYP 303 Naegleria gruberi
XP_002070081 283 TEKQe----PCP--IQLGHARLSIVSHVWew---kgKRLIASAYP 318 Drosophila willistoni
EDW41986     284 TAEEe----PCH--IQLGHASATIVSHGWkw---ngMRLIGTAYP 319 Drosophila sechellia
XP_002053222 286 TAEKe----PCE--IQLGTAKLSIVSHVWdw---kgKRLIASTYv 321 Drosophila virilis
Q9GYM9       534 HGNGg----NCH--FKVTNYPITVTSYLQdcg-dgsGTCLATAYP 571 Caenorhabditis elegans
PDM80296     735 HTGEa----GCK--FSIDDVPLAVTSYTQdca--ggGLCLSTSYP 771 Pristionchus pacificus
Q7NF33       301 SEQGllrqeKRQ--TTINGARYNLVLYRSttpqgsrGDFIRSFYP 343 Gloeobacter violaceus
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