Conserved Protein Domain Family
XLF

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pfam09302: XLF 
XLF-Cernunnos, XRcc4-like factor, NHEJ component
XLF (also called Cernunnos) is Xrcc4-like-factor, and interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining. It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated down-regulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining. This family contains Nej1 (non-homologous end-joining factor), and Lif1, ligase-interacting factor. XLF forms one of the components of the NHEJ machinery for DNA non-homologous end-joining.
Statistics
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PSSM-Id: 401298
View PSSM: pfam09302
Aligned: 85 rows
Threshold Bit Score: 62.7412
Threshold Setting Gi: 401838114
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHA55072       9 WRPLPV-SHHA-VPNLLVSAAFStsPV-SYSV-YITDLAN--VWLERLDRRAILLRSLE---EKTSIDPSDDP-----EN 74  Pyricularia ory...
Q9P7J2         3 WVQLRGhR------FHFIQASFDaeSNeAVQViHITDLVR--VWSCTCSRNQIVNQAES---ERCPIDPF--------QT 63  Schizosaccharom...
CCE85273       8 WFSTSLsSQGTeKVKLLYGYEFSgeSK-SYLI-CTTDLND--VWIERLNKSQIIKKAKRfgiEDLS------------DK 71  Millerozyma far...
Q6BKD1         8 WNSIFIpFVN--PRKVIYGYQCDfnNK-AYSI-YITDFKN--VWLERLSKQDIIDKANSygiEDTED-----------EK 70  Debaryomyces ha...
XP_011276195   7 WNVLNIdSPK----KYYYGVDFSteKI-HYSL-YITDFSN--VWISDVDEEKLHFKAIQngiETESIN----------GV 68  Wickerhamomyces...
CCC69827      16 WHSCTInGQ-----PFLFSLNLSdnEE-STLFfINADQHP--TFKACISSNDIKAQCTIqgfPSDSVTKITKEtykqiHQ 87  Naumovozyma cas...
Q06148        15 WCVKKInGEG---NCLLLFLPMSspTT-IVMI-VLVSLERlvPYVFKLSQTQLSQQCQSqgfTDS-------------IS 76  Saccharomyces c...
Q6FMQ7         5 WKVGEIdG--------------------RYNL-----LKQ------DIDRDGTKLLKITihmTEALLVPQSSTlkkslKT 53  [Candida] glabrata
XP_011429696  19 WQPITIdKQ-----QYLFKCKYT--HN-SYEL-LFTDNCN--FWFERLEGAELEKRTVS---LNPSVK----------AT 74  Pacific oyster
P53150       125 W-------------KVVMELESSaiIR------KIAELTLhpVKKGEIDLFEMADKLYK---DICCVNDSYRNikesdSS 182 Saccharomyces c...
EHA55072      75 FKELLHRIGSAF----------DAENphh--adaSLALTSgletptgGV--N------DLILEV------TC-------- 120 Pyricularia ory...
Q9P7J2        64 FETLVDVLAEVLvnvs----------------------------sesRIqlRgsndegSLKIFC------TS-------- 101 Schizosaccharom...
CCE85273      72 VEDLLAVFSEGFgsr-----------------skNKTLKF-------EIndQslgatdVINIIF---------------- 111 Millerozyma far...
Q6BKD1        71 LHYLLEVLRNGVecg-----------------dvDKTLLFsi----tKInrTmsdnenTIQAKF---------------- 113 Debaryomyces ha...
XP_011276195  69 YHTLISTFENNF--------------------------NSedvetrvDMneMkidkgiPLELRL------NL-------- 108 Wickerhamomyces...
CCC69827      88 LRSF-KKIEDGS----------------------------------------------RLQLTIvlsgdiTL-------- 112 Naumovozyma cas...
Q06148        77 LNLIKLKLMDIL----------QAPQeinqiglvDSNLVF------------------SFDVSA---------------- 112 Saccharomyces c...
Q6FMQ7        54 YAVKLDSARKQLksqgfdlqssDNLIkivieflnNLNCYTknnykdsKCemSlhksdmKITIKLdatikaTInlgfvrlt 133 [Candida] glabrata
XP_011429696  75 ATRILDEIQNCLe---------NSTKkmsvtvteNKK---------------------KLDIYV------DS-------- 110 Pacific oyster
P53150       183 NRNRVEQLARER----------------------------------------------ELLDKL---------------- 200 Saccharomyces c...
EHA55072     121 ---------ILPAGLQPLKWPIKLK--HGGASA---VATELVLPLVQ---AQMARQLELEALLAVIKEKDGVIS------ 177 Pyricularia ory...
Q9P7J2       102 ---------KIAKDI-FLEWNWTLW--LTPPET---IAKMVWFPLINhhlFESETDTSPGSLMSIIRDQKSLLNdktw-- 164 Schizosaccharom...
CCE85273     112 --------------AQDIQWRFELQ--KQSHQIateFFASMNIQQFR---NHAFLDYKIQQLERAIKDKDHYIL------ 166 Millerozyma far...
Q6BKD1       114 --------------TGEIDWDFSVV--KQSPSNaidVISQINFQQFE---NHNYLNYKVEQLERLINIKDHYIV------ 168 Debaryomyces ha...
XP_011276195 109 ---------VKVYSNAELNWNFDLV--ILPDSSaitILRNLIFHLST---IIFSLNEYKNDLIKVVEHKDSAIR------ 168 Wickerhamomyces...
CCC69827     113 ---------NLTTIILGLSMQEQLT-----------LSENLIRQTLR---IIHIQGLYSNHLLNVITEKDSVIQ------ 163 Naumovozyma cas...
Q06148       113 ----------------DITVSINSVpsHVTKDMfymILQSLCMLLLK---LVNLSTQYHYVQRDILNEKQKCLD------ 167 Saccharomyces c...
Q6FMQ7       134 deqgllillELSHFLSETLWYWSRVcsLIDSES---NTKNLNNCLI--------------ELNRIAEAK----------- 185 [Candida] glabrata
XP_011429696 111 ---------QLAGM--AFVWKFQCT--QADSQL---ISENFNVPLLA---MVAELARRNEELVKIIGAKDKEI------- 164 Pacific oyster
P53150       201 ---------------------------LETRDE---RTRAMMVTLLN------EKKKKIRELHEILRQNNIKLSdddvld 244 Saccharomyces c...
EHA55072     178 ---------KVLDKLDGMGARLD------QIF 194 Pyricularia oryzae 70-15
Q9P7J2       165 ------fkeALNERSSSSNPSTPrk---rSAF 187 Schizosaccharomyces pombe 972h-
CCE85273     167 ---------YLEQNYKAVNGN--------EII 181 Millerozyma farinosa CBS 7064
Q6BKD1       169 ---------YLSENYKAINGD--------ELI 183 Debaryomyces hansenii
XP_011276195 169 ---------FLGESIEGMNGG--------HLV 183 Wickerhamomyces ciferrii
CCC69827     164 ---------FLSDSLNDLGAS--------KII 178 Naumovozyma castellii CBS 4309
Q06148       168 ---------FLLISLRDLDGGS-------KVI 183 Saccharomyces cerevisiae S288C
Q6FMQ7       186 ------------ESNQIYGRDLAklfiirEKL 205 [Candida] glabrata
XP_011429696 165 ------------DDYKSQGAKTSrkhietPVF 184 Pacific oyster
P53150       245 salintevqKPISELNSPGKRMKrr---kTVV 273 Saccharomyces cerevisiae S288C
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