Conserved Protein Domain Family
MspA

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pfam09203: MspA 
MspA
MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel.
Statistics
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PSSM-Id: 401226
View PSSM: pfam09203
Aligned: 48 rows
Threshold Bit Score: 90.5008
Threshold Setting Gi: 502892890
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Tpau_1505    54 TGVLVRVGLRKPQVDVYPPLDSSPFSREAFLSMTGAVALG-GNAKEIAKSKTsLDVGYQIGYPVTVAKd-gVKVGLvtpn 131 Tsukamurella...
Q0S4X9           49 DGTVVTVNLTDESANISPSMGSTPLHRNVWVNGKASVHLD---GAGAT-GAD-IQPGYVLACQVDFGAeagGEAGStpvv 123 Rhodococcus ...
WP_025352842     48 DGTVVHVWLDGESANIGRFPGTMPVYRNAGVSGTAHVELT---GGTTVVGGS-IYPGYTVGCQVDLs---gAGTGAkvdw 120 Nocardia nova
UANL:O3I_022100  45 DGTVLTVRLVGESATISPSMGATPVHRNAWVSGSAQVELS---GSDAV-GGK-IYPGYVVGCQVTLKGg-gVNGGVdakt 118 Nocardia bra...
Q5YZF5           52 DGTVVTVRLVGESATISPSMGATPVHRNAWVSGSAQVEIS---GGGEDVGGK-IYPGYVVGCQVNIDGg-gVEGGVegsa 126 Nocardia far...
CCF65488         48 DGTVVTVRLVGESANINPSMGSTPVHRNAWVSASAQVELS---GSGAK-GGK-IYPGYVVGCQVNIGGg-gVEGGVsgeg 121 Nocardia cyr...
WP_013138191     53 DGTVVTVSVRDQYATIAPAMVAVQTSRNIWANGTVRVDVE---GSIDE--GR-ITPGYVVGCQFTFGAsagGSFNS---- 122 Segniliparus...
WP_012833254     47 DGTPITVTLFDQFANHQRAVTNVQTSREVWVSGKVRVNVG-----GKADGGS-IKVGYDVGCQVTFGAeagAYGGVdstk 120 Gordonia bro...
Q5Z1E5           39 GGVEFTVGHRDHAVRPAPSLNGMPTNRDLYVDNTFYGRINaGTGT--------LSAGYLVACAVDLTAe--LNLGA---- 104 Nocardia far...
jgi:Tpau_3830    49 EGVNAQIALFDLKARLFPPLAGDNKSRLAYVDGKAEGTITkAPGE--IEAAT-VEVGYVVACGVK-DGgfeSWIGS---- 120 Tsukamurella...
jgi:Tpau_1505   132 ltvnagltpevgvgaNAGVTPKAGVDGSvtggggtsggngsgtvggnagvevplgvngsaKVGADLGAKSDIIPsqkfdf 211 Tsukamurella...
Q0S4X9          124 nadgtvs----------------------------------------------------vpvdggtsagITLGP------ 145 Rhodococcus ...
WP_025352842    121 rdgana----------------------------------------------------gpddggrtggNLILGP------ 142 Nocardia nova
UANL:O3I_022100 119 dwegkk-----------------------------------------------------peiggkaggNLTLGP------ 139 Nocardia bra...
Q5YZF5          127 dwsgdtv---------------------------------------------------tggvgaesggELTLGP------ 149 Nocardia far...
CCF65488        122 twdges-----------------------------------------------------fgvgaesggELSLGP------ 142 Nocardia cyr...
WP_013138191    123 -----------------GHSSPGLGIGVtalnaaigtglaatdplgaatalggagltaasQYVPQGNIGFSIGP------ 179 Segniliparus...
WP_012833254    121 dglrp-------------------------------------------------------nsdtgitgAVTLGP------ 139 Gordonia bro...
Q5Z1E5          105 ---------------EIGVDADLRAGVSigpesvlp----------------gldvdmgpYLGAGIGVDLSLSP------ 147 Nocardia far...
jgi:Tpau_3830   121 ---------------NQTIGAAGAIAGSipaagaa-------------------lvgvggSLGLTQNQVIKTAP------ 160 Tsukamurella...
jgi:Tpau_1505   212 tighGEIKEVSL----------------SKFDV-K---KSDAILEVGGTEVSVTATAGRVSIRPYVRATIETDRGRITTV 271 Tsukamurella...
Q0S4X9          146 ----GEAVSVDIldlesada-yggeshsAYNSF-E---GTDGSVTWADSTLGVSGCAGYAQARSYVNVSVETDNVSSTVT 216 Rhodococcus ...
WP_025352842    143 ----GQARSFYVlgseepgd-fgadahrARDRF-E---GSEGSVAWTDETIGLTGCPGAAQARAFVSVEVETDNVISWVT 213 Nocardia nova
UANL:O3I_022100 140 ----GQAKSLYLldqeeadd-fgneshsTRNKF-K---GTSGSVTWADSTIGVQGCAGYAQARAFVRVKVATATVNSVVT 210 Nocardia bra...
Q5YZF5          150 ----GQAKSFYIldiekpdd-ygnedhaTNNKF-K---GNSGSVTWADSTIGLSGCAGYAQARSFVKVKVETDNVMSVVT 220 Nocardia far...
CCF65488        143 ----GQAKSFYVldieeadd-fgnesheKRNKF-K---GKSGSVTWADQTIGLTGCAGYAQARAFVKVKVETENVMSVVT 213 Nocardia cyr...
WP_013138191    180 ----GQAVEVPMlrieepdd-ygnqtfdNYFAF-A---GNHGGISYTDVTFKVDDCAGYAQARPYSRVRIKNAKTMAWVT 250 Segniliparus...
WP_012833254    140 ----GQVKTVWVinttsgdstayedyevNDYTF-K---GNKGGVVYSQEKFGVDGCAGYASARPRIQVTVSTDSVKSVTV 211 Gordonia bro...
Q5Z1E5          148 ----GTVVDLPV----------------GEHPLhP---GDEGYLFSRDRRIHVEGCGGPLTVQPYVFLTVDAAEVRADGA 204 Nocardia far...
jgi:Tpau_3830   161 ----GGIVYLPV----------------GSKTIqKpkpGENFGVRFGEKRVSIEGCIGSVDAVAYSTLTVSSRAFDDMKT 220 Tsukamurella...
jgi:Tpau_1505   272 VYGDV 276 Tsukamurella paurometabola DSM 20162
Q0S4X9          217 LWGQP 221 Rhodococcus jostii RHA1
WP_025352842    214 LWGNS 218 Nocardia nova
UANL:O3I_022100 211 LWGQP 215 Nocardia brasiliensis ATCC 700358
Q5YZF5          221 LWGQP 225 Nocardia farcinica
CCF65488        214 LWGQP 218 Nocardia cyriacigeorgica GUH-2
WP_013138191    251 IWGPP 255 Segniliparus rotundus
WP_012833254    212 LNGKP 216 Gordonia bronchialis
Q5Z1E5          205 VFGDP 209 Nocardia farcinica
jgi:Tpau_3830   221 VYSev 225 Tsukamurella paurometabola DSM 20162
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