1SJ7


Conserved Protein Domain Family
Talin_middle

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pfam09141: Talin_middle 
Talin, middle domain
Members of this family adopt a structure consisting of five alpha helices that fold into a bundle. They contain a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin.
Statistics
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PSSM-Id: 401182
View PSSM: pfam09141
Aligned: 22 rows
Threshold Bit Score: 123.161
Threshold Setting Gi: 167518654
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SJ7_A         11 QQALTGTINSSMQAVQAAQATLDDFETL--PPL-GQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLT--AGDPA 85  
XP_002108146  471 KAAFLSNISAGFMAASATTAALDEPAEL--PDL-GSDPASLQWKRNTLHISQENVRANIAAINGSAAAIILLT--SNPDK 545  Trichoplax ad...
EDO47777      506 QQAYMSSLSQGIDSVDTADEELKRPVNI--VAL-GSDPASLKWKQNTLDVSRQNVASRLAALSASCASIVNVT--SGEPG 580  starlet sea a...
XP_011673604  513 QQNLMTNIKRGFTAMEEARNDLGTRAEL--PPL-GSDQASRQWRDNAMDVNKQNIQSQLSAMAAATAGIISET--SGAAE 587  purple sea ur...
XP_018673454  494 QQAFMGNIEHGFNACRAAHEGFNNKANL--PPL-GSDAASKQWKLNALEENRHNIQSNLAAIDAATATVITKT--SGDRE 568  vase tunicate
Q95XN3        526 QRALIGTIEATIRAVEDAEIELEAEPQIdiPRF-NDDYSQNRWMEEQQAVNKENVNERLAAMGAATAQVVQWTavEEYDD 604  Caenorhabditi...
XP_004997176  460 QSTLANHISRANRVFVLAGKKIASPATL--PPL-GESASAHRWREEKDLLARQNVAAEVAAILSATANIVTLTtaRSDNT 536  Salpingoeca r...
EKC18519      456 QRALLTCIEEGITSIRQAESQMDKGAAL--PNL-GNDAASKKWRQNMLDLSRQKVGAQLSAMNAATAQLVTMS----IDD 528  Pacific oyster
XP_009029379  498 QRALLGRIGAGLTSMKGIQNDLETKGQV--PQL-GTDPASIKWRETAMDNSRQRLSAQLSAMNAATAQVVMLTrdNNNPD 574  Helobdella ro...
CDS35718      506 KRAVMHRIDESTKEIQDASDSLQKPYFEdnDTVsRDDSATQRWREENMAQARAGICSYLGAMTIATGNLVSLLqlSSHNR 585  Echinococcus ...
1SJ7_A         86 E---------------TDYTAVGCAVTTISSNLTEMSRGVKLLAALLE----DEggNGRPLLQAAKGLAGAVSELLRSAQ 146 
XP_002108146  546 E---------------IDYTAIGSSVTTISSNMNDMAKRIKMIAALQD----DE--YSVDLITATKELASAFVKLLKSSQ 604  Trichoplax ad...
EDO47777      581 D---------------TNYTAAGAAVHVISANLQDLSKGIKLIAGLLD----NQd-DSSKLLDAARGLAGAFSLLLKAAQ 640  starlet sea a...
XP_011673604  588 D---------------TDYTAVGSHVTTISSNLTEMTKGVKMLAALLG----NEg-DSEKLLGAARDLMDAFSDLLKFAQ 647  purple sea ur...
XP_018673454  569 G---------------TNYTTVGSAITTISSNLNDMTKSLRLMAALLD----DGr-DGDGLMKAARDLTAAIQDLLKAAQ 628  vase tunicate
Q95XN3        605 R--------------------VGTAIATIGSNLPDVSRNVRDLGAFME----HR--ERGDLLDATKKLCGAFGKFLNTVN 658  Caenorhabditi...
XP_004997176  537 K---------------VNFTAVGASISTLASNMRSAAEDVAMLMALNP----VQ---ADNFKSALEQLSSHLRSFVDTVA 594  Salpingoeca r...
EKC18519      529 E---------------IDTSRVGAAVAQITSNIDDFSQDVRMLGALQD----DDa-SRNKLLGAAKRLCGAFSDLLNAAE 588  Pacific oyster
XP_009029379  575 S---------------TDYSAVGSAVQTISANLNNFSQDVRMLAAMEE----NEk-EGTALMGAARLLVGAFSDLLIAVQ 634  Helobdella ro...
CDS35718      586 VgdssqegmeeeeedaIDYTAMDASLATIGLNVQRLMQNVRVLDQLQAvdagDE--SQGHITNAAQDVADAFLKLMQSAM 663  Echinococcus ...
1SJ7_A        147 Pa--------sAEPRQNLLQAAGNVGQASGELL 171 
XP_002108146  605 Pe--------sMESRQSLLEAANDAGIHSKRIL 629  Trichoplax adhaerens
EDO47777      641 Egag-----gdKEKRSQLLNAAGNVGSSGAQLL 668  starlet sea anemone
XP_011673604  648 Pd--------sQEPRQNLLGAANRVGETQNALL 672  purple sea urchin
XP_018673454  629 Pn--------sEEPRQNLLGAAGKIGDASHDIL 653  vase tunicate
Q95XN3        659 Pe--------tEARRNEVFRTAGHVGETSQHLI 683  Caenorhabditis elegans
XP_004997176  595 Pte------rgIMNRQNILSSANQVGQSGSALL 621  Salpingoeca rosetta
EKC18519      589 Pg--------qKEGKSNLITAAKTVGEASQEVM 613  Pacific oyster
XP_009029379  635 P-----------KPRQNILNAANRVGEASQGIm 656  Helobdella robusta
CDS35718      664 PlkegkqgsgtVVDRPSLYEAASRVGDTSQQLL 696  Echinococcus multilocularis
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