Conserved Protein Domain Family
Mmp37

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pfam09139: Mmp37 
Mitochondrial matrix Mmp37
MMp37 is a mitochondrial matrix protein that functions in the translocation of proteins across the mitochondrial inner membrane. It has been shown that MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane.
Statistics
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PSSM-Id: 401180
View PSSM: pfam09139
Aligned: 118 rows
Threshold Bit Score: 238.192
Threshold Setting Gi: 217404705
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007672357      36 LRQILW-RFRApIRYAFAYGSGVFAQQSSksmtetsmsphpnppkavedWQKGGAKIIDFIFGVSHTQHWHSLNLMEHPD 114 Baudoinia p...
A0ECV7             9 LKQFIQ-TLPQ-SELSFAYGSAVQPQFNY--------------------DYTKNKPMIDLIIAVDNVEEWHMQNIQINST 66  Paramecium ...
XP_001018527      17 LDSIIQrDFPK-IDFAFGYGSGVFRQIGY--------------------DYSKDSPMIDLIFGVQDADEWHRMNLIKNPS 75  Tetrahymena...
Q9SN75             9 LSSFLS-VLPP-VDFCCVYGSTLHPNN------------------------QDKSKMVDYILGVSDPIKWHSANLKMNSD 62  thale cress
CBI27230           9 LASLLK-FLPP-VEFCCVYGSALHPNN------------------------YNKSTMVDYILGVSDPMQWHSQNLKMNRD 62  wine grape
XP_003524826       6 FRSFLQ-VLPP-VEFACVYGSSLHPSN------------------------HDKTTMTDYILGVSDPKQWHSENLKLNKH 59  soybean
XP_002299388       9 LKSFLK-VLPP-VGFCCVYGSSLHPNN------------------------NDKSTMVDYIIGVSDPKQWHSKNMELNED 62  black cotto...
XP_002528146       9 LKNFLE-VLPS-VEFCCVYGSALHPNN------------------------QDKSSMVDFILGVSDPRQWHSENLKLNRD 62  castor bean
jgi:MICPUN_79022  10 LRAVLE-DVPP-VNHAFGYGSGVLPQPlrddeg----------psasarDHAATGSVVDFVFAVDDPRAWHRRNMAMNPS 77  Micromonas ...
EEH57855           9 LGVVLN-DLPP-VVHAFAYGSAVFPQP------------------------ASSGSVVDYVLAVDAPDEWHAANMAANPS 62  Micromonas ...
XP_007672357     115 HYSFLRHLpySSAAISHIQDD-FGAGVYFNPYITVN----------GTMIKYGVVNLDTLSRDLSEWNTLYLAGRLQKPV 183 Baudoinia p...
A0ECV7            67 HYSGLSYYl-GSRFIQRMNVEiF--PIHFSPFVQYQ----------DLKLKYGVVSTKELIKDLENWKWLSIAGRMQKPI 133 Paramecium ...
XP_001018527      76 HYSGLGYYl-GSSYLHFLQQYiT--PVHFNPSIQVDsfd----qkrKLNIKYGVVDVKQLSKDLLKWNILTCSGRLHKPV 148 Tetrahymena...
Q9SN75            63 HYASWMVHlgGARLITNVADK-VGVGVHFNPFVNWN----------DRKLKYGVVRMHDLVQDILDWKRFYLSGRLQKPV 131 thale cress
CBI27230          63 HYASSMVYlgGAKLITQVADE-IGVGVHFNPFVSVN----------DEMFKYGVVRMHDLVEDVLNWETFYLSGRLQKPV 131 wine grape
XP_003524826      60 HYASWMVHlgGESLITGVADR-IGVGVHFNPFVTWN----------GKLFKYGVIQMHDLLQDVQYWEKFYLCGRLQKPV 128 soybean
XP_002299388      63 HYASWMVPlgGAKLITQVADK-IGVGVHFNPFVTWN----------DKMLKYGVVRMHDLVQDVLHWERFYLCGRLQKPV 131 black cotto...
XP_002528146      63 HYASWMVHlgGAKLITEVADE-IGVGVHFNPFITWN----------DKMLKYGVVRMHDLVQDILNWERFYLSGRLQKPV 131 castor bean
jgi:MICPUN_79022  78 HYAPHLRAl-GGGTVAALADR-VGAGVHYNTLIPWTktihpsarlaPTTFKYGVVSVNAMCDDLVNWRHMFVAGRMQKPV 155 Micromonas ...
EEH57855          63 HYAAHLRLl-GARSPGWIADR-VGVGVHYNTLLPWPctttr-phdgARLYKYGVVSVEALTRDLTRWSDLFVAGRMQKPT 139 Micromonas ...
XP_007672357     184 KIL--RD-------DPRIRLANQVNLISALRTALLMLPEKF-S---ERQLYERIAGLSYTGDPRMNplFaSENPNKISNI 250 Baudoinia p...
A0ECV7           134 VTIqeFE-------DLRFQRAFIANLQSALAVAILMD---FkSsmsLQELLYSVISLSYYGDIRFT--LgGENQNKVFNI 201 Paramecium ...
XP_001018527     149 KIIqlDQv-----qNPTLNSDLRVNLIQATAISLLLN---FkPyieMKEFLMTIASLSYIGDVRFL--FgAENKNKIQNL 218 Tetrahymena...
Q9SN75           132 HML--VD-------NLDIEDVNSVNKRAAISAALLLLPSKF-T---EEDLYAKICSLSYMGDLRMF--F-AEDTNKVNKI 195 thale cress
CBI27230         132 QVL--VD-------NLDIGNLNSVNLKGAISAALLLLPAKF-T---EEHLYAKICSLSYMGDLRML--F-AEDRNKVKKI 195 wine grape
XP_003524826     129 HIV--VD-------NLDVNSTNSVNLRAAVSAALLLLPSEF-T---EEDLYAKVCSLSYTGDIRML--F-AEDKNKVKKI 192 soybean
XP_002299388     132 HIL--VD-------NLDIGDVNSVNLRAAVSAALLLLPSKF-T---EEDLYSKICSLSYMGDLRML--F-AEDKNKVKRI 195 black cotto...
XP_002528146     132 HIL--VD-------NLDIGNVNSANLRAALSAALLLLPSKF-T---EEDLYSKICSLSYMGDLRML--F-AEDKNKVKKI 195 castor bean
jgi:MICPUN_79022 156 VALggAI-------DPRVTAAQSINARSALAAALLLLPEEF-S---REDLLGSLCGLSYAGDVRVA--LgAEDVDKVRRI 222 Micromonas ...
EEH57855         140 TTL--TTttaafaaDASLRAASEANLRAALAAALLMLPETF-S---TRELHETLCGLSYEGDVRTA--FgAEDVGKIPRV 211 Micromonas ...
XP_007672357     251 VGAQLPGFRQLYVPLIENLPNvhfsdprtpRDHAWekedairhtgtnpqldnvlggadGLELE--QNMDPVPRGNMVRRL 328 Baudoinia p...
A0ECV7           202 LKGNYKNITDLYLSNLGDLNNvik---------------------------------iqKDGEvlIDNSIKSLEFLCSKI 248 Paramecium ...
XP_001018527     219 VEGNYDRFTHLYKDVIEQNNPinslaqvvgNRAE------------------------HIKLE----TNSETVYQLVNCL 270 Tetrahymena...
Q9SN75           196 VKGQFDLFQSMYKPFLEECETknllrfssaEASH-------------------------TKLV--QDSSLSATRSLVSSL 248 thale cress
CBI27230         196 VQVQFDLFQTMYKPLLEEYGAkgllrfsssDGHQ-------------------------AIIS--QDCGLSVARSLVSSL 248 wine grape
XP_003524826     193 VTGQFDLFHSMYKPFLEEYEAkkllrlsstANNQ-------------------------IHAT--QDCDLSVACALVSAL 245 soybean
XP_002299388     196 VEGQFGLFQSMYKPFLKEYEAkelltfslpNSHQ-------------------------ATIS--QDCSLSMTHSLVHSL 248 black cotto...
XP_002528146     196 VQGQFGLFHSMYRPILQDYEAkellrfsssDYQ--------------------------SNIS--QDCGLSVTRSLVRAL 247 castor bean
jgi:MICPUN_79022 223 ATGSERGLMEMYRDAVKVVGSdlagltmgrGGEVW-----------------------S------RDGSPAARSALFATL 273 Micromonas ...
EEH57855         212 AAGSRAGLREMYADAIARFRSnpaigltavGTSVD-----------------------RGDCDwgQDKSAAARSALLETL 268 Micromonas ...
XP_007672357     329 PKAFRRKLYFQYKKKFgipgaaftdvleasededatsMRkREGGDFERRIAAEA-D---LPETVGRCVRNTVGWPSTTQS 404 Baudoinia p...
A0ECV7           249 PGQLLSIVLGE-----------------------------KDNMGTLKMMSQDR-----IKDLIKESVKRKNQFSSKRML 294 Paramecium ...
XP_001018527     271 PDGL---GLFA-----------------------------RTNEINVKIINLED-----VQRQIIERIRKINMGSSQKLI 313 Tetrahymena...
Q9SN75           249 PASVRSQMGKSLGEKK---------------------FVsETGRVMGEVCISSReE---AAKCMEKVMRRRVMVSSGRQA 304 thale cress
CBI27230         249 PSKVRSQMGMKLGEKT---------------------KLsESGRVLREVVVGSReE---AAECMRGVLRRKVMVSSARQA 304 wine grape
XP_003524826     246 PPSIRSQISKN-GE------------------------LtETGRFIHDTKVSAReV---AANCLQRILRQRVMVSSARQA 297 soybean
XP_002299388     249 PPLVRRKMGMKLGEMQ---------------------VLkDSGRVLHEVVIGSReE---AARSMQRIIRRTVMVSSARQA 304 black cotto...
XP_002528146     248 PPLVRSKMGMKLGEEK---------------------LWsDSGRFLHEVIIGSReE---AAKCMHKVLRRTVMISSARQA 303 castor bean
jgi:MICPUN_79022 274 PRETLHKTMSA-----------------------------------RMLVKFEDaGgrsAVESLRECLRGTVRKSSLRQL 318 Micromonas ...
EEH57855         269 PRKALALAAVS---------------------------AgAGAEAAAAAIASRA-SperTRDVVRRAIDAIVFRSSARQL 320 Micromonas ...
XP_007672357     405 IKGVFTSGFAKSWKYLGEKRSK 426 Baudoinia panamericana UAMH 10762
A0ECV7           295 FYNLAMISPFLSVKYGISKLSK 316 Paramecium tetraurelia
XP_001018527     314 LYNTLATSPTKNIYYVFKKLQK 335 Tetrahymena thermophila SB210
Q9SN75           305 VSGFLAAGAINATMYLSQKMRK 326 thale cress
CBI27230         305 VSGLVAVGGVNAIRYLANKMEK 326 wine grape
XP_003524826     298 ISGLLAVGGVNATRYLSKKVSK 319 soybean
XP_002299388     305 VSGFLAAGGINATRYLANKVRK 326 black cottonwood
XP_002528146     304 ISGLLAAGGINATRYLASKVCK 325 castor bean
jgi:MICPUN_79022 319 LAGLLATSPSKSARYAASKLFK 340 Micromonas commoda
EEH57855         321 MSGILSTSPRKSLTYALGKAVK 342 Micromonas pusilla CCMP1545
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