1IYJ


Conserved Protein Domain Family
BRCA-2_OB1

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pfam09103: BRCA-2_OB1 
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BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.
Statistics
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PSSM-Id: 401152
View PSSM: pfam09103
Aligned: 86 rows
Threshold Bit Score: 82.221
Threshold Setting Gi: 124457019
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IYJ_D                         266 SALKKILERDDTAAKTLVLCVSDIISLSTNVSETsgskasSEDSNKVDTIELTDGWYAVKAQL--------------DPP 331  Norway rat...
EHS62527                       831 SALKRILDNDCPSSMPMCLVIVGIIRRPGPSSAT------KGIPVTTEILELSDGWYKIKAHL--------------DPV 890  Puccinia graminis f. sp. tritici CRL 75-36-700-3...
EGG11618                       557 SAVRLMLDNEAPLGAPVCLFVSSIKSSRNFLEgka--twkANESMTDCKLELSDGWYKINCVI--------------DAT 620  Melampsora larici-populina 98AG31...
EPB88637                       387 PVLRKILEQDDNSVKHMVLVIADIIKTENSSFYN---------TSTKYRLVLSDGWYKIHSCI--------------DLR 443  Mucor circinelloides f. circinelloides 1006PhL...
WGS:AAFB:cds.EHI_121840A       271 sFYRQIYNKDENCGYCHIGVVANIISKELTKEYP--------------LLLMSDGWYTIQIQI--------------DQG 322  Entamoeba histolytica HM-1:IMSS...
WGS:AAGF:cds.TTHERM_00437260A 1717 SILKQIQEQDAVKSLNMVLIVANITKVNQYGCY---------------VLELSDGWYSFFVVVldhkhvisndlyqqNNK 1781 Tetrahymena thermophila SB210...
A0CSV2                         233 tIIQEIWTNDQSLNQHMILLVVGVEQCQSRR-----------------ILELSDGWYSLFFVC--------------EQS 281  Paramecium tetraurelia...
EEA08220                       691 SAIVKICEGDISVSVPLALKVLTYeqg----------iidGICDNSKVIFTCTDGWYLIKICC--------------DFG 746  Cryptosporidium muris RN66...
CAM67384                       424 PALRKMVEGDISSASLVVLYMSSVSEERSSPHMR--------------IVTLSDGIYHLKVTC--------------DVP 475  Leishmania infantum JPCM5...
Q4DNW3                         324 PALRVLTEGDVPASSLLVVSVVCLSLEERLAPHTs-------------VGVISDGCYEIKVAL--------------DVP 376  Trypanosoma cruzi...
1IYJ_D                         332 LLAL--VKSGRLTVGQKIITQGA------------ELvg-sPDACAPLE-----------------APDSLRLKISANST 379  Norway rat...
EHS62527                       891 LARV--LKRGTLRVGFKLAISGA------------ST----EAPAGPSSkssgekkstilketddgKEEEVRLYLEGNAT 952  Puccinia graminis f. sp. tritici CRL 75-36-700-3...
EGG11618                       621 LFRA--ISNGRIKVGHKLAIGAV------------SLrsssLNQSNPSRvvn------------elSVDEPELVLEGNST 674  Melampsora larici-populina 98AG31...
EPB88637                       444 MEHA--ITRKKLKIGHKLSICGA------------QIig-dKTAQSPLSi----------------KESDTLLSITSNGC 492  Mucor circinelloides f. circinelloides 1006PhL...
WGS:AAFB:cds.EHI_121840A       323 INEL--IKQNKIYIGQKLRICCL------------EKte-dWNEREPWE------------------GKELIFKTNINCI 369  Entamoeba histolytica HM-1:IMSS...
WGS:AAGF:cds.TTHERM_00437260A 1782 ILQLdlIKRNKIYIGMKMYVNNL------------AK-----PSVGNLEnmin---------pkqnILYQNVYEIFYNNI 1835 Tetrahymena thermophila SB210...
A0CSV2                         282 FDQI--YNR--IKIGQKLHVTNLkeypiifntsnvKI-----ITQYPFT--------------------KLLVTTKINSI 332  Paramecium tetraurelia...
EEA08220                       747 NLKC--SIKTF---PSKIFICGS------------TWks-nVELGHPLEie-------------ysIGDIPTLNVGLNLI 795  Cryptosporidium muris RN66...
CAM67384                       476 LSNL--IREGVLKPGQRMAVCGA------------KSl--lHRQCAPTE-----------------CEEQVVLSINYNCV 522  Leishmania infantum JPCM5...
Q4DNW3                         377 LTNL--VREGILRCGHKLLVCGA------------KMl--lKNFCSPVD-----------------CRDDVVLSINYNCT 423  Trypanosoma cruzi...
1IYJ_D                         380 R-PARWHS-KLG 389  Norway rat
EHS62527                       953 S-RARWPE-TLG 962  Puccinia graminis f. sp. tritici CRL 75-36-700-3
EGG11618                       675 S-RVRWFE-TLG 684  Melampsora larici-populina 98AG31
EPB88637                       493 L-PARWDE-KLG 502  Mucor circinelloides f. circinelloides 1006PhL
WGS:AAFB:cds.EHI_121840A       370 R-RGERNE-KLG 379  Entamoeba histolytica HM-1:IMSS
WGS:AAGF:cds.TTHERM_00437260A 1836 I-KAPANS-KLG 1845 Tetrahymena thermophila SB210
A0CSV2                         333 K-KAQINS-KLG 342  Paramecium tetraurelia
EEA08220                       796 RpLTKSKStKLG 807  Cryptosporidium muris RN66
CAM67384                       523 R-AVAQQT-PLG 532  Leishmania infantum JPCM5
Q4DNW3                         424 R-PVDPTA-ALG 433  Trypanosoma cruzi
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