1IKQ


Conserved Protein Domain Family
Exotox-A_target

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pfam09102: Exotox-A_target 
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Exotoxin A, targeting
Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for transmembrane targeting of the toxin, as well as transmembrane translocation of the catalytic domain into the cytoplasmic compartment. A furin cleavage site is present within the domain: cleavage generates a 37 kDa carboxy-terminal fragment, which includes the enzymatic domain, which is then is translocated into the cytoplasm. The domain adopts a helical structure, with six alpha-helices forming a bundle.
Statistics
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PSSM-Id: 401151
View PSSM: pfam09102
Aligned: 2 rows
Threshold Bit Score: 226.906
Threshold Setting Gi: 17943391
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IKQ_A   252 EGGSLAALTAHQACHLPLETFTRHRQPRGWEQLEQCGYPVQRLVALYLAARLSWNQVDQVIRNALAS-PGSG-------G 323 Pseudomonas aeruginosa
KMN83734 262 KENALGALSAHRVCGIPLESLARSRQPRGWEELSACGFRVENIVGLYIATRLSFDRFRQVVDDLIHSrPVSGaqdpealA 341 Chromobacterium sp....
1IKQ_A   324 DLGEAIREQPEQARLALTLAAAESERFVRQGTGNDEAGAANADVVSLTCPVAAGECAGP-AD 384 Pseudomonas aeruginosa
KMN83734 342 QLGTAVRETPEMAREGLAEAEARLNAYRANHAGASADDAQRADVLSLTCPADSEPCAAAnAD 403 Chromobacterium sp. LK11
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