2Q1F,1HN0


Conserved Protein Domain Family
Lyase_N

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pfam09092: Lyase_N 
Lyase, N terminal
Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a jelly-roll fold topology consisting of a two-layered bent beta-sheet sandwich with one short alpha-helix. The convex beta sheet is composed of five antiparallel strands, whilst the concave beta-sheet contains five antiparallel beta-strands with a loop between two consecutive strands folding back onto the concave surface. This domain is required for binding of the protein to long glycosaminoglycan chains.
Statistics
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PSSM-Id: 401146
View PSSM: pfam09092
Aligned: 16 rows
Threshold Bit Score: 207.995
Threshold Setting Gi: 550276465
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Q1F_A           21 RXFSFEEPQLPACIT--GVQSQLGISGAHYKDGKHSLEWTF-EPNGRLELRKDLKFEKKDPTGKDLYLSAFI------VW 91  
jgi:Bache_0583   30 RLLSFEERRVPSFVt--ATDSRLTVSNEHYRDGTQSLCWSF-GPKSILSIKKDLKFEPKDPTGKDTYLSAFI------VW 100  Bacteroides...
CCY39300         31 RLLSFEAPEVPSFIs--SENSQLSITTEHYKDGAQALNWKF-EPGSILSIRKDLQFEPKDPTGKDTYLSGFV------VW 101  Tannerella ...
CDA77469         30 RVISFEENKVPDn----WKGAGLAINTAHYKDGKQSMQWTF-KPGETISLKKDVMFQKKDPTGKDLYLSTFT------GW 98   Bacteroides...
Q0WIL0           48 SIIDFDGNQLPDFVTa-SSGSTLSLSSTRYIMGQQSLKWEW-QAGSTMTIEHPITLVTDKVASKTWGRKATQvl---sFW 122  Yersinia pe...
WP_012368258     40 EIYHFAQSDPLADFSs-DKNSTLTLSDKRSIMGNQSLLWQW-KGGSSFTLHKKLIVPTDKEASKAWGRASTPvl---sFW 114  Proteus
Q8A2F5           20 QVIGFEEK-VPETFKv-SGKGEVKLSSLFYKEGESSLEWDF-QPASTLDVQIE-PLSLNAKKEQQFGIT---------LW 86   Bacteroides...
WP_022603073     20 IQYDFEDGVIPTTINd-IQKGTLSVSSDHAKMGTKSLRWDW-TATGAL-------FRVNDEVNIPYAIKAFSnrgglrMW 90   Coprobacter...
WP_014790153     18 GAQSFEGNTLPQEVKisGKKSTISLSDKYYKDGKQSLLWQWvAPQSTLVFASP---------DIAKSVKNFKkragvkLW 88   Ornithobact...
OKZ06238         31 RLLSFEEA-VPQELs--GAGSTLSLSDEHYKDGSRSLRWTY-KPGAVLSLKKDLKFEAKDPTGKDTYLSAFI------VW 100  Bacteroides...
2Q1F_A           92 IYNEQPQ-DAAIEFEF---L-KDGRKCASFPFGINFKGWRAAWVCYER-------DXQGT-------------------- 139 
jgi:Bache_0583  101 VYNEQAQ-DKTIEFEF---L-RNGKKCTSFPFGINFIGWRGAWVCYER-------DMQGT-------------------- 148  Bacteroides...
CCY39300        102 IYNKKAT-DKSLNFEF---L-KDGKICSHFPMGLNFTGWRAAWVCYER-------DMQGT-------------------- 149  Tannerella ...
CDA77469         99 FYNTKAI-NDSIRVGF---Y-KEGKECCHFNLRTAFTGWRAAWVCFER-------DMQGT-------------------- 146  Bacteroides...
Q0WIL0          123 IYNETPV-DDYMIVDLgrgLgPSGAPDAGIKVKMNFSGWRTVGVSLQN-------DLEGReiegigfddnaegesggrst 194  Yersinia pe...
WP_012368258    115 LYNEKPI-DGYLTVDLgekLnATSEAQAGFKVKLNFTGWRAIGISLNN-------DLENRemtlnatntss---dgtqds 183  Proteus
Q8A2F5           87 IYNEKPQ-QDSIRFEF---LnKAGEVSYWFTYHLQAAGWRACWISFAY-------MNGDK-------------------- 135  Bacteroides...
WP_022603073     91 IYSPKAMpGKSLQFIF---RnKTVRV-YTFDFNLNFTGWRACWIAFSDmwvpgesDDVQP-------------------- 146  Coprobacter...
WP_014790153     89 VFNEKPQ-KTPLVFNF---VdAQGQVQYTFDFNLNFTGWRAAWISYSDmw---tpDGGKT-------------------- 141  Ornithobact...
OKZ06238        101 VYNEKAV-DKKITFQF---L-KDGKVCTSFPFGINFTGWRAAWVCYER-------DMEGT-------------------- 148  Bacteroides...
2Q1F_A          140 ----PEEGXNELRIVAP-DAK-GRLFIDHLITATKvDARQQTADLQVPF 182 
jgi:Bache_0583  149 ----PETGMDEIRVVAP-EVK-GKLFIDHLITASKvDARQQTADLQVPF 191  Bacteroides helcogenes P 36-108
CCY39300        150 ----PEIGMNEIRIVAP-DET-GELCIDHLLTAAKmDHRYQTADIQVPF 192  Tannerella sp. CAG:118
CDA77469        147 ----PQEGMDEVRFTAPkSSE-GQICIDLMIPSVKtDHRHQTADRQVPF 190  Bacteroides sp. CAG:530
Q0WIL0          195 iaggAKSDMDSIRFRAPlKAPaGIFYIDRVMLSID-DARYQWSDDHVKT 242  Yersinia pestis
WP_012368258    184 igrsLGANVDSIRFKAPsNISqGEIYIDRIMFSID-DARYQWSDYQIKT 231  Proteus
Q8A2F5          136 ----KDKNIVSYRLVAP-DRK-GRIFLDRLTFPEKkMNLRTTPDQQLPA 178  Bacteroides thetaiotaomicron
WP_022603073    147 ----TQQDIDELTIKAPeGVEsGTLYFDRWDFSSNiN-KQATPDAQIPK 190  Coprobacter fastidiosus
WP_014790153    142 ----TEKPIVAMNVISPkNVSnSHIFIDRVSFENYvD-RQATPDAQIPE 185  Ornithobacterium rhinotracheale
OKZ06238        149 ----PEEGMNELRILAP-DVE-GELFIDHLIPASKvDARQQAADVQVPF 191  Bacteroides plebeius
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