6MOI


Conserved Protein Domain Family
EpoR_lig-bind

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pfam09067: EpoR_lig-bind 
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Erythropoietin receptor, ligand binding
Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Statistics
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PSSM-Id: 401127
View PSSM: pfam09067
Aligned: 12 rows
Threshold Bit Score: 128.308
Threshold Setting Gi: 82086619
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MOI_B  11 SKAA-LLAARGPEELLCFTERLEDLVCFWEEAASAGVgpgqYSFSYQle-dEPWKLCRLHQAPTARGAV-RFWCSLPTA- 86  human
Q6IYE8  37 SQDA-ALLAEVPEDILCFSRSFEDLTCFWDEEEASAI----HRFYYW----DAPTTCAVSTQRSGVSGM-RHICVFPSQ- 105 chicken
P40238  25 SQDV-SLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSg--tYQLLYAyp-rEKPRACPLSSQSMPHFGT-RYVCQFPDQe 99  human
Q6UAP8  19 SSEG-TSPPGKPTLIQCRSPEKETFTCWWKPGSDGDLpt-tYALYYRkensDTVHECPDYQTAGENS------CFFNKN- 89  spotted green pufferfish
Q9PTH9  24 SLNA-QSPPGKPEIIKCRSYEKVTFSCWWKPASDGGLpt-nYSLLYRkendPKIYECPDYETSGLNS------CYFDKA- 94  African clawed frog
Q9DE08  21 QGAR-HTPPGKPKLTSCRSPDKETFTCWWEAGSDGGRpt-tYSLFYHkensETVYECPDYHTAGANS------CFFNKN- 91  rainbow trout
Q8QG54  18 SQAAgVSAPGKPKLTSCRSPEKETFTCWWEPGEDGGLpt-tYALYYHlensETVYECPDYKTAGNNS------CFFNKN- 89  common carp
Q6UAP7  33 KKVS-IMLKEDPKNPKCFAEGRKDFICFWEEDEERAGsvdqYTFTYAyq-nENSSRCPLKSISAADSKR-LFICHLN--- 106 spotted green pufferfish
Q2VBQ8  29 SKVA-QLIRDETEDIKCFVEGKKDFTCFWEKEDGTNYsqdnYTFTYTym-nENKMDCAVSSLFLLSSNRsVFFCKLP--- 103 zebrafish
Q4W815  43 RHIS-EKIPEEYQNPHCFTRDLNDFICFWEGERRKN-----ASFSYSe--dDQIKWCQLRTEVASNNTW-WYICEFPVT- 112 African clawed frog
Q6EIY6  23 RQPK-PELLAMDEDPKCFTRNLEDFTCFWDAPVEKS-----YDFLYIieglMEEKRCDVKQQTFEEKI--LNICTFPPS- 93  zebrafish
Q6UAN4  34 SEED-LLLFKDDEFLKCFTSTQFDFTCFFETSDNRT-----YDLSYNvn---gTEMCELFVRKTDEGTL-LHICSFPEV- 102 spotted green pufferfish
6MOI_B  87 DTSSFVPLELRV-TAASGAPRYHRVIHIN 114 human
Q6IYE8 106 DVRLFTPLHVLVlDTTTNRTRHRRELSVD 134 chicken
P40238 100 EVRLFFPLHLWVkNVFLNQTRTQRVLFVD 128 human
Q6UAP8  90 NTSLWVYYNITVvATNELGSTFSD--SVD 116 spotted green pufferfish
Q9PTH9  95 HTSFWVFYHIYVnATNALGSNVSEELSVD 123 African clawed frog
Q9DE08  92 ETSIWVNYNITVvATNALGNNFSD--PVD 118 rainbow trout
Q8QG54  90 DTSLWVNYNITVvATNALGKNISE--PVE 116 common carp
Q6UAP7 107 RIKMFVQMDIQV--HREGMLIHNRSLLVE 133 spotted green pufferfish
Q2VBQ8 104 KALFFTSLDVQV--LRDGQMLYNRSLNVE 130 zebrafish
Q4W815 113 DVVLFAGITISA--YPCHKCQTAREIYIN 139 African clawed frog
Q6EIY6  94 DVYLYVETHIRViDKDTNTTIYSRAVSVE 122 zebrafish
Q6UAN4 103 DVHLFVEIHLEVgERGTNTSLYNRTVCVE 131 spotted green pufferfish
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