Conserved Protein Domain Family
Kp4

?
pfam09044: Kp4 
Kp4
Members of this fungal family of toxins specifically inhibit voltage-gated calcium channels in mammalian cells. They adopt an alpha/beta-sandwich structure, comprising a five-stranded antiparallel beta-sheet with two antiparallel alpha-helices lying at approximately 45 degrees to these strands.
Statistics
?
PSSM-Id: 370259
Aligned: 14 rows
Threshold Bit Score: 110.518
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_006966511   9 VAIAAAQSAVGLGINCHGDTRCGIAYLSGgRLSHLGTVIKKIDD----TRKYENGEDIACIEIDSL--NFKGpfkstLCA 82 
XP_013942640   9 LAAATAQSAAGLGINCEGDSLCGISYLAGgRLTQFQSIFDNIFE----KRIWDNGDDIGCVEMTHL--NFQGsfkgvYCA 82 
CCT72676       8 ASAVLALGASAEGINCHGSSNCANAGF---KLTGLLQTAQGLND----NKWYYNGQHIACWQALDKt---------gFCA 71 
EMR66332       9 AALSLATGTYSLGINCQGNSNCGGTLC---SLTDILASVKALPQ----NNLYNPGDHIACCGDSAl---ASG-----ICA 73 
CEF71898       6 TLTTLLSAASALGINCRGSGWCNINSA---SLDNVLTKAKQLQArgqgDHHWGEGVQIAC-----SggQWGS-----ICA 72 
CCT64970       9 ALAATAGLSDALGINCRGSGLCSGNKG---ALGQLIAQVRAIDP----NKTFRNGEHVSCVDIN-NigNHPA-----ICA 75 
EFY91383      10 FAAALMGTSSALGINCRGSGLCASNKG---ILGQAQGQLRGMDQ----NQQFSDGQHITCVKSSVTigN-PS-----LCI 76 
XP_006963527   9 AAASVASVVNALGINCQGSGLCTGNKG---ALGNLLGQVKALDQ----SKTFSDGEQIACVESSVSigN-PS-----LCL 75 
EED55833       8 IVASALTANAKLGINCRGSAKCSVLWGPSdAAQQLTNVIQHIDT----NRWYMNGEHIACVGNQAg--NGGG-----YCA 76 
XP_002374614  13 AITLVSSSSAKLGINCRGSANCNTFGNTQ-MAFQLKRAIDGIDP----NRWYNNGEHIACVGSGARitGNGG-----FCA 82 
XP_006966511  83 WIEn--YDDTVSGAAIKA--AFQELLDHGCGICGAVPLLYAKGVDDVNKGELNVDLVD 136
XP_013942640  83 YIQn--LDGSVDGATLKS--LYTELIEYGCGICGSIPIHYAKGDNDVNHGELSFNMVD 136
CCT72676      72 FLQ---NTGGLPGKDIKK--LLQELVNHGCAKCGSVPAFYPSDNDIKSHGMLTVNYVS 124
EMR66332      74 FVQgdfHDGQISASTAAG--LLQDLVNHGCGKCGSVP--IGPNNDPNADGILTVNWVS 127
CEF71898      73 FFQ---S--GASGNTDRAveLIQGILDHGCTQCGSIPT---EEGNNVDNGQLTVNYVE 122
CCT64970      76 FYQ---NIGDRSFSLAQTqtFLQQIVDHGCKLCGSVPT---DPGNNVANGQLTVNVVI 127
EFY91383      77 FYQ---NTNGRRWTVAQTvnFVQQLLDHGCAACGSVPT---DPGNDVKHGELTANMVT 128
XP_006963527  76 FYQ---KT-GRTFTVAQTvwYVQALIDHGCQACGSIPV---DDGNNVDNGELTANMVa 126
EED55833      77 FLQ---KTGGTNGGVIKN--LAHYITDHGCKQCGSVPYYFPQGNNNVDDGELTYNYVD 129
XP_002374614  83 FLQ---NTGGTNGAVIKS--LAHYIPEHGCKVCGSVPYFYPQGNNNVDDGELTFNYVD 135
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap