Conserved Protein Domain Family
DFF-C

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pfam09033: DFF-C 
DNA Fragmentation factor 45kDa, C terminal domain
The C terminal domain of DNA Fragmentation factor 45kDa (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4). The main function of this domain is the inhibition of DFF40 by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFF40, the C-terminal region of DFF45 is also important for the DFF40-specific folding chaperone activity, as demonstrated by the ability of DFF45 to refold DFF40.
Statistics
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PSSM-Id: 401104
View PSSM: pfam09033
Aligned: 21 rows
Threshold Bit Score: 218.001
Threshold Setting Gi: 973211763
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011475250  86 DGGTAWMQRESVMLe-mDTVD-TGs--SLAPWLDLAQQLKQDLTSIILMSEADLQLLVDAPSTELAAALGFQVKKAEDLQ 161 Japanese medaka
Q5CZL3       102 DGGTAWLARDSMEVedeNMVD-GA---DLTRWKNLALQLKEDLSNIILMSESELQILTEVSVDELAGVVGVSCEKVQSLQ 177 tropical clawed...
XP_015192696  86 DGGTAWL---GVGGe-aDEVD-RAv-pGAEGWQEPARRLQQDLSAIVLMSEADLQGLADAPCGTLAAALGYEEARTRALQ 159 spotted gar
XP_007246842  85 DGGTAWLRSETVEMe-tDAVD-SGmdnGVEPWRTVADKLKQNLANIILMSEADLQSLVDVPHKDLGLALGFTPEKTQDLQ 162 Mexican tetra
CAG07553      87 DGGTAWMARDSLMMe-tDAVDfSGg--ADAHWWFLAQQLKQDLTSIILMSEEDLQTLVDVPHQQLASAMDFQEKKAQDLQ 163 spotted green p...
4_pfamImport   1 DGGTAWMARDSMLVe-aDTVD-ASs--AAAPWLDLAQQLKRDLASIILMSDEDLQTLVDAPSIELASAVGFQEKKAQDLQ 76 
XP_005478278  85 DGGTAWMARDSVLLe-tDTVD-SSs--TVAPWYELAQQLKQDLTSIILMSEADLQTLVDAPCPELASALGFQEKKAQELQ 160 Nile tilapia
XP_003228081  93 DGGTAWLEGEVTDI---DGPE-SG----EEKWQRLARQLKDDLSTIILMSEEDLQALIDVPCLDLARELSDTQAKVQALQ 164 green anole
XP_417610     87 dsrsawLSEPA------DEVD-SG----AERWRQLARQLRADLSNIILMSEEDLQVLIDVPRSDLAEELAQNQTKTQVLQ 155 chicken
XP_030144969  87 DSGTSWLSESV------DEVD-SA----AEKWKQLARQLKDDLSNIILMSEEDLQVLIDVPCSDLAEELAQSETKVHVLQ 155 zebra finch
XP_011475250 162 ETLQNVLDRREEERQSKELLQLYLRTVEKEDKQLEEASQSSTGtgVAGD--VDVPDG-----SEVDS----ASGFMSRTL 230 Japanese medaka
Q5CZL3       178 NIIQRVMDRREEERQSKQLLELYLEAVKKE-----KTSEPDSIy-FAE----DEVDSggntqTQLSC----KSLVSSHIM 243 tropical clawed...
XP_015192696 160 DTLQGVLDRRQEERQAKELLQLYLRAAQGE-SRAGETAGPRGA--RIEVpgQDVTDGk---eMEVDAagrgASKFSQRTL 233 spotted gar
XP_007246842 163 DTLQSVLDRREEERQSKELLQLYLKAVEKEGGQALQQTDGKG---------LDEADG-----EGAES----DSGFCSGTL 224 Mexican tetra
CAG07553     164 DTLQRVLDRREEERQSKELLQLYLKAVAKE-REQDESSQAAEA--------ADGSDL-----TEVDS----ATGFMSRTL 225 spotted green p...
4_pfamImport  77 ETLQRVLDRREEERQSKELLQLYLKAAEKEGGQQADQSRPGQEe-AGD---LGV-ET-----MEVDS----GSGFVSRTL 142
XP_005478278 161 ETLQRVLDRREQERQSKELLQLYLKTVEQENRQQEETSQPSQGg-AGD---VDVPDG-----MEVDS----ASGFMSRTL 227 Nile tilapia
XP_003228081 165 ETLQQVLDRREEERQSRQLLELYLQAVKNEDHIVPKREEATDT--AMEE--ADTVDAgg--sSRVAA----TVPLSSHIL 234 green anole
XP_417610    156 DTLQQVLDRREEERQSKQLLELYLEALKNEDSILSKVAESESV--PRKE--MDVVDTgt-ssAGASA----RTALSDHIF 226 chicken
XP_030144969 156 DTLQQVLDRREEERQSRQLLELYLEALKTEDSILSKVAEPEAA--PRKE--MDVVDTgt-ssTDTSA----TTALSGQVL 226 zebra finch
XP_011475250 231 MVLKGKTSPETRLSTEDLQMVV 252 Japanese medaka
Q5CZL3       244 EILKKKDLPHLSLSNKELENVN 265 tropical clawed frog
XP_015192696 234 MVLKGKTSPETRLSNQELQLLi 255 spotted gar
XP_007246842 225 LVLKGRTSPETRLSNEELQMVV 246 Mexican tetra
CAG07553     226 MVLKGKTSPETRLSTEDLQMIV 247 spotted green pufferfish
4_pfamImport 143 MVLKGKTSPETRLSTEDLQMVV 164
XP_005478278 228 MVLKGKTSPETRLSTGDLQMVV 249 Nile tilapia
XP_003228081 235 TALREKTAPELSLDSQDLELVN 256 green anole
XP_417610    227 AVLKEKPAPELCLDSQTLELVV 248 chicken
XP_030144969 227 AALKEKRAPELCLDSQDLELVL 248 zebra finch
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