1YSM


Conserved Protein Domain Family
Siah-Interact_N

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pfam09032: Siah-Interact_N 
Siah interacting protein, N terminal
The N terminal domain of Siah interacting protein (SIP) adopts a helical hairpin structure with a hydrophobic core stabilized by a classic knobs-and-holes arrangement of side chains contributed by the two amphipathic helices. Little is known about this domain's function, except that it is crucial for interactions with Siah. It has also been hypothesized that SIP can dimerize through this N terminal domain.
Statistics
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PSSM-Id: 401103
View PSSM: pfam09032
Aligned: 23 rows
Threshold Bit Score: 67.4087
Threshold Setting Gi: 555706221
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YSM_A         5 LEELQKDLEEVKVLLEKSTRKRLRDTLTSEKSKIETEL-------KNKMQQKSQkkpELDNEKPA----AVVAPLTTGYT 73 
EDO40906       4 LEELKQDCDELRAFIAESSRARVKEVLQRELIKLEQEVsllsrekPASTDQPNA----TAEEKPS----SSKPVTVSSYT 75  starlet sea ane...
EDS27781       6 IDNLQLDLEELRNLAAQAKRSKVQQLLSIDIRKLETDLlackqkqEASATATTA--------KPP----APVAGDCKRYR 73  southern house ...
Q16JJ2         6 IENLTLDLEELKQLAEGAKRNRVQQMLSIDIRKLETDLlyqkellAAKEKEQST----GESSKPP----APVPGDVKRYR 77  yellow fever mo...
ETN59945       6 IDNLTLDLEEMRKLAASAQRSRVQQMLAIDVRKLETDIqrqrdllAAQASSEQS------VTRPVqqtpVSAPGDIRRYQ 79  Anopheles darlingi
Q7PYU2        52 IENLTLDLEEMRKLAGSAQRSRVQQMLAIDIRKLETDIqrqrdllAAQAASSEQ-----TVARPVq---TSVPGDVRRYQ 123 Anopheles gambi...
XP_004931799   6 IQEIRSDIEEINDLLKQAKRKKVQDLLSLEIRKLETELitlkekeTLTPMEVSP--------IPTt---STSAPVQKKYQ 74  domestic silkworm
OWR40912       6 VNELKSDIDELKDLLKQAKRKKVQDLLSLEIRKIETEVialkessKDAAPNEAA-------SVPTts-aSSAPPPKKRYQ 77  Danaus plexippu...
XP_008212484   5 INEIKMDIDDLNSLLDKASRQKSKDVLNLEIRRLQTELlnlsqnqISTNQENKA-------SKPV----AN--SALKCYD 71  jewel wasp
ESO09454       8 VSETQLDIDDLNNLLKVATRPKVKQLLNQEIAKLSSSSlpscstaSSTSTTSPE---LPQQAEPI----TKVVSIPRKYY 80  Helobdella robusta
1YSM_A        74 VKI 76 
EDO40906      76 KKI 78  starlet sea anemone
EDS27781      74 VEL 76  southern house mosquito
Q16JJ2        78 IEL 80  yellow fever mosquito
ETN59945      80 VEL 82  Anopheles darlingi
Q7PYU2       124 VEL 126 Anopheles gambiae str. PEST
XP_004931799  75 VKL 77  domestic silkworm
OWR40912      78 VKI 80  Danaus plexippus plexippus
XP_008212484  72 VKL 74  jewel wasp
ESO09454      81 --I 81  Helobdella robusta
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